Co-Target(s) Information

Content Navigation (  All   None )                                      
Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T97155 Target Info
Target Name Serine/threonine-protein kinase ATR (FRP1)
Synonyms
FRAP-related protein 1; Ataxia telangiectasia and Rad3-related protein
    Click to Show/Hide
Target Type Clinical trial Target
Gene Name ATR
Biochemical Class Kinase
UniProt ID
ATR_HUMAN
Co-Targets of This Target  Top
Co-Target Name Fms-like tyrosine kinase 3 (FLT-3) Successful Target
UniProt ID FLT3_HUMAN
Gene Name FLT3
Synonyms
Stem cell tyrosine kinase 1; STK1; STK-1; Receptor-type tyrosine-protein kinase FLT3; Fetal liver kinase-2; FLT-3; FLK2; FLK-2; FL cytokine receptor; CD135
    Click to Show/Hide
Representative Drug(s) VX-970 Drug Info Ki = 18 nM [1]
Co-Target Name Glycogen synthase kinase-3 alpha (GSK-3A) Successful Target
UniProt ID GSK3A_HUMAN
Gene Name GSK3A
Synonyms
Serine/threonineprotein kinase GSK3A; Serine/threonine-protein kinase GSK3A; Glycogen synthase kinase3 alpha; Glycogen synthase kinase 3; GSK3 alpha; GSK-3 alpha; GSK-3
    Click to Show/Hide
Representative Drug(s) VX-970 Drug Info Ki = 33 nM [1]
Co-Target Name Tyrosine-protein kinase Kit (KIT) Successful Target
UniProt ID KIT_HUMAN
Gene Name KIT
Synonyms
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; p145 c-kit; Proto-oncogene tyrosine-protein kinase Kit; Proto-oncogene c-Kit; Piebald trait protein; PBT; Mast/stem cell growth factor receptor Kit; CD117 antigen; CD117; C-kit
    Click to Show/Hide
Representative Drug(s) VX-970 Drug Info Ki = 39 nM [1]
Co-Target Name Tyrosine-protein kinase ABL1 (ABL) Successful Target
UniProt ID ABL1_HUMAN
Gene Name ABL1
Synonyms
p150; Proto-oncogene tyrosine-protein kinase ABL1; Proto-oncogene c-Abl; JTK7; C-ABL; Abl; Abelson tyrosine-protein kinase 1; Abelson murine leukemia viral oncogene homolog 1
    Click to Show/Hide
Representative Drug(s) VX-970 Drug Info Ki = 59 nM [1]
Co-Target Name Janus kinase 2 (JAK-2) Successful Target
UniProt ID JAK2_HUMAN
Gene Name JAK2
Synonyms
Tyrosine-protein kinase JAK2
    Click to Show/Hide
Representative Drug(s) VX-970 Drug Info Ki = 150 nM [1]
Co-Target Name Tyrosine-protein kinase SYK (SYK) Successful Target
UniProt ID KSYK_HUMAN
Gene Name SYK
Synonyms
p72-Syk; Spleen tyrosine kinase
    Click to Show/Hide
Representative Drug(s) VX-970 Drug Info Ki = 190 nM [1]
Co-Target Name Serine/threonine-protein kinase mTOR (mTOR) Successful Target
UniProt ID MTOR_HUMAN
Gene Name MTOR
Synonyms
Target of rapamycin; TOR kinase; Rapamycin target protein 1; Rapamycin target protein; Rapamycin and FKBP12 target 1; RAPT1; RAFT1; Mechanistic target of rapamycin; Mammalian target of rapamycin; FRAP2; FRAP1; FRAP; FKBP12-rapamycin complex-associated protein; FKBP-rapamycin associated protein; FK506-binding protein 12-rapamycin complex-associated protein 1
    Click to Show/Hide
Representative Drug(s) AZD6738 Drug Info IC50 = 370 nM [2]
Co-Target Name Vascular endothelial growth factor receptor 3 (FLT-4) Clinical trial Target
UniProt ID VGFR3_HUMAN
Gene Name FLT4
Synonyms
VEGFR3; VEGFR-3; VEGF-3 receptor; Tyrosine-protein kinase receptor FLT4; Fms-like tyrosine kinase 4
    Click to Show/Hide
Representative Drug(s) VX-970 Drug Info Ki = 8 nM [1]
Co-Target Name Mixed lineage kinase 1 (MAP3K9) Clinical trial Target
UniProt ID M3K9_HUMAN
Gene Name MAP3K9
Synonyms
PRKE1; Mitogen-activated protein kinase kinase kinase 9; MLK1
    Click to Show/Hide
Representative Drug(s) VX-970 Drug Info Ki = 15 nM [1]
Co-Target Name Tyrosine-protein kinase Mer (MERTK) Clinical trial Target
UniProt ID MERTK_HUMAN
Gene Name MERTK
Synonyms
Receptor tyrosine kinase MerTK; Proto-oncogene c-Mer
    Click to Show/Hide
Representative Drug(s) VX-970 Drug Info Ki = 30 nM [1]
Co-Target Name ATM serine/threonine kinase (ATM) Clinical trial Target
UniProt ID ATM_HUMAN
Gene Name ATM
Synonyms
Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
    Click to Show/Hide
Representative Drug(s) VX-970 Drug Info Ki = 44 nM [1]
Co-Target Name Glycogen synthase kinase-3 beta (GSK-3B) Clinical trial Target
UniProt ID GSK3B_HUMAN
Gene Name GSK3B
Synonyms
Serine/threonine-protein kinase GSK3B; GSK-3 beta
    Click to Show/Hide
Representative Drug(s) VX-970 Drug Info Ki = 140 nM [1]
Co-Target Name Dual-specificity tyrosine-phosphorylation regulated kinase 2 (DYRK2) Patented-recorded Target
UniProt ID DYRK2_HUMAN
Gene Name DYRK2
Synonyms
Dual specificity tyrosine-phosphorylation-regulated kinase 2
    Click to Show/Hide
Representative Drug(s) VX-970 Drug Info Ki = 26 nM [1]
Co-Target Name PI3K p110 alpha/p85 alpha (PIK3CA/PIK3R1) Co-Target
UniProt ID PK3CA_HUMAN-P85A_HUMAN
Gene Name PIK3CA-PIK3R1
Representative Drug(s) VX-970 Drug Info Ki = 140 nM [1]
References  Top
REF 1 Rational Design of 5-(4-(Isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine (VX-970, M6620): Optimization of Intra- and Intermolecular Polar Interactions of a New Ataxia Telangiectasia Mutated and Rad3-Related (ATR) Kinase Inhibitor. J Med Chem. 2019 Jun 13;62(11):5547-5561.
REF 2 Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent. J Med Chem. 2018 Nov 21;61(22):9889-9907.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.