Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99799 | Target Info | |||
| Target Name | Cholinesterase (BCHE) | ||||
| Synonyms |
Pseudocholinesterase; Choline esterase II; CHE1; Butyrylcholine esterase; Acylcholine acylhydrolase
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| Target Type | Successful Target | ||||
| Gene Name | BCHE | ||||
| Biochemical Class | Type-B carboxylesterase/lipase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Acetylcholinesterase (AChE) | Successful Target | ||||
| UniProt ID | ACES_HUMAN | |||||
| Gene Name | ACHE | |||||
| Synonyms |
YT; N-ACHE; ARACHE
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| Representative Drug(s) | Eptastigmine | Drug Info | IC50 = 5 nM | Click to Show More | [1] | |
| 2 | (-)-Phenserine | Drug Info | IC50 = 21 nM | [2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease. Eur J Med Chem. 2011 Jun;46(6):2170-84. | ||||
| REF 2 | Alfred Burger award address. Bioactive alkaloids. 4. Results of recent investigations with colchicine and physostigmine. J Med Chem. 1990 Sep;33(9):2311-9. | ||||
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