COVID-19 Drug Information
Drug General Information | Top | |||
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Drug ID |
D0KQ8H
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Drug Name |
PMID21925774-compound-5e
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Synonyms |
PMID21925774-C-5e
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Drug Type |
Small molecular drug
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Indication | Severe acute respiratory syndrome (SARS) | Preclinical | [1] | |
Therapeutic Class |
Antiviral Agents
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Structure |
Download2D MOL |
Target | Top | |||
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Target(s) | SARS-CoV helicase (Hel) | Target Info | Inhibitor | [1] |
3-iodobenzyloxy-substituted derivative 5e shows the most potent activity against SARS-associated coronavirus (IC50 = 11 microM for helicase activity). |
References | Top | |||
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1 | 2,6-Bis-arylmethyloxy-5-hydroxychromones With Antiviral Activity Against Both Hepatitis C Virus (HCV) and SARS-associated Coronavirus (SCV) Eur J Med Chem. 2011 Nov;46(11):5698-704. |
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