Target Information
Target General Infomation | Top | ||||
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Target ID |
T89917
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Target Name |
SARS-CoV helicase (Hel)
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Synonyms |
SARS-CoV Helicase; SARS-CoV Hel
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Gene Name |
SARS-CoV rep; SARS-CoV 1a-1b
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Target Status |
Target in Preclinical Study
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[1] | |||
Disease | [+] 1 Target-related Diseases | + | |||
1 | Severe acute respiratory syndrome [ICD-11: 1D65] | ||||
Function |
Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium.
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BioChemical Class |
Coronaviruses polyprotein 1ab family
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UniProt ID | |||||
EC Number |
EC 3.6.4.12
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Sequence |
AMYTPHTVLQAVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVISTSHKLVLSVNPYVC
NAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGSDNVTDFNAIA TCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVREVLSDRELHLSWEVG KPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGTTTYKLNVGDYFVLTSH TVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSH FAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSRIIPARARVECFDKFKVNS TLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARLRAKHYVYIGDPAQLPAPRT LLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVYDNKLKAHKDKSAQ CFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKAVFISPYNSQNAVASKILGLPT QTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRAKIGILCIMSDRDLYDKLQFTSL E |
Drugs and Modes of Action | Top | ||||
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Preclinical Drugs | [+] 2 Preclinical Drugs | + | |||
1 | SSYA10-001 | Drug Info | Preclinical | SARS | [2] |
2 | PMID21925774-compound-5e | Drug Info | Preclinical | SARS | [1] |
Mode of Action | [+] 1 Modes of Action | + | |||
Inhibitor | [+] 2 Inhibitor drugs | + | |||
1 | PMID21925774-compound-5e | Drug Info | [1] | ||
2 | SSYA10-001 | Drug Info | [2] |
References | Top | ||||
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1 | 2,6-Bis-arylmethyloxy-5-hydroxychromones With Antiviral Activity Against Both Hepatitis C Virus (HCV) and SARS-associated Coronavirus (SCV) Eur J Med Chem. 2011 Nov;46(11):5698-704. | ||||
2 | Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. |
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