Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00KHM
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| Former ID |
DAP000316
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| Drug Name |
Pimozide
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| Synonyms |
Antalon; Neoperidole; Opiran; Orap; Pimozida; Pimozidum; Primozida; ASTA Medica Brand of Pimozide; Janssen Brand of Pimozide;Orap forte; Pharmascience Brand of Pimozide; P 1793; R 6238; McN-JR 6238; Orap (TN); Pimozida [INN-Spanish]; Pimozidum [INN-Latin]; Primozida [INN-Spanish]; R-6238; McN-JR-6238; Pimozide (JAN/USP/INN); Pimozide [USAN:INN:BAN:JAN]; 1-(1-(4,4-Bis(p-fluorophenyl)butyl)-4-piperidyl)-2-benzimidazolinone; 1-(4,4-Bis(p-fluorophenyl)butyl)-4-(2-oxo-1-benzimidazolinyl)piperidine; 1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one; 1-[1-[4,4-Bis(p-fluorophenyl)butyl]-4-piperidyl]-2-benzimidazolinone; 1-[1-[4,4-bis(4-Fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one; 1-[4,4-Bis(p-fluorophenyl)butyl]-4-(2-oxo-1-benzimidazolinyl)piperidine; 1-{1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one; 1-{1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one; 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1H-benzimidazol-2-one
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| Drug Type |
Small molecular drug
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| Indication | Schizophrenia [ICD-11: 6A20] | Approved | [1], [2] | |
| Therapeutic Class |
Antipsychotic Agents
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| Company |
Janssen Pharmaceutica
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| Structure |
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Download2D MOL |
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| Formula |
C28H29F2N3O
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| Canonical SMILES |
C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F
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| InChI |
1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
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| InChIKey |
YVUQSNJEYSNKRX-UHFFFAOYSA-N
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| CAS Number |
CAS 2062-78-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9769, 563187, 855710, 6706026, 7847626, 7980325, 8137196, 8149730, 8162258, 10321421, 11111615, 11112507, 11113804, 11335561, 11360800, 11363339, 11365901, 11368463, 11372540, 11373859, 11376625, 11447004, 11461772, 11466336, 11467456, 11484947, 11486231, 11488842, 11491266, 11492235, 11494259, 12013418, 14882544, 17405504, 24277923, 26612186, 26680826, 26747138, 26747139, 26751488, 26751978, 26751979, 29284219, 46507096, 47275121, 47275122, 47423792, 47572947, 47720184, 47720185
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| ChEBI ID |
CHEBI:8212
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| ADReCS Drug ID | BADD_D01774 | |||
| SuperDrug ATC ID |
N05AG02
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| SuperDrug CAS ID |
cas=002062784
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Anaerotruncus colihominis DSM 17241
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pimozide can be metabolized by Anaerotruncus colihominis DSM 17241 (log2FC = -1.725; p = 0.01). | |||
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Studied Microbe: Clostridium sp.
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pimozide can be metabolized by Clostridium sp. (log2FC = -0.774; p = 0.013). | |||
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Studied Microbe: Enterocloster bolteae ATCC BAA-613
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pimozide can be metabolized by Enterocloster bolteae ATCC BAA-613 (log2FC = -0.558; p = 0.028). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia muciniphila ATCC BAA-835
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Pimozide can be metabolized by Akkermansia muciniphila ATCC BAA-835 (log2FC = -1.128; p = 0.04). | |||
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides uniformis
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Pimozide (adjusted p-values: 2.36E-03). | |||
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Studied Microbe: Bacteroides vulgatus
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Pimozide (adjusted p-values: 1.70E-03). | |||
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Studied Microbe: Parabacteroides distasonis
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides distasonis was decreased by Pimozide (adjusted p-values: 9.10E-03). | |||
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Studied Microbe: Prevotella copri
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Prevotella copri was decreased by Pimozide (adjusted p-values: 4.27E-03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Eubacterium rectale
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Pimozide (adjusted p-values: 2.19E-04). | |||
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Studied Microbe: Roseburia hominis
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|
[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia hominis was decreased by Pimozide (adjusted p-values: 4.04E-04). | |||
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Studied Microbe: Roseburia intestinalis
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Pimozide (adjusted p-values: 1.27E-03). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 90). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 017473. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 5 | [The benzamides tiapride, sulpiride, and amisulpride in treatment for Tourette's syndrome]. Nervenarzt. 2007 Mar;78(3):264, 266-8, 270-1. | |||
| REF 6 | Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. | |||
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