Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00SEB
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| Former ID |
DAP000585
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| Drug Name |
Enalapril
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| Synonyms |
Vasotec; Enalapril (INN); Enalapril (TN); N-{(1S)-1-[(ethyloxy)carbonyl]-3-phenylpropyl}-L-alanyl-L-proline; N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-proline; (2S)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Approved | [1], [2] | |
| Therapeutic Class |
Antihypertensive Agents
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| Company |
Merck & Co
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| Structure |
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Download2D MOL |
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| Formula |
C20H28N2O5
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| Canonical SMILES |
CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CCCC2C(=O)O
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| InChI |
1S/C20H28N2O5/c1-3-27-20(26)16(12-11-15-8-5-4-6-9-15)21-14(2)18(23)22-13-7-10-17(22)19(24)25/h4-6,8-9,14,16-17,21H,3,7,10-13H2,1-2H3,(H,24,25)/t14-,16-,17-/m0/s1
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| InChIKey |
GBXSMTUPTTWBMN-XIRDDKMYSA-N
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| CAS Number |
CAS 75847-73-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9191, 7979157, 11112847, 11335583, 11360822, 11364201, 11366763, 11369325, 11372634, 11373494, 11377487, 11461794, 11485085, 11489271, 11491293, 11491823, 11495121, 14779899, 14877707, 17185069, 29214998, 39404326, 46507920, 47365119, 47588933, 47588934, 47810682, 48110391, 48184936, 48415941, 49698433, 50073899, 50103938, 50103939, 53787340, 57362754, 75931775, 89736144, 92309084, 93166909, 96024588, 99313640, 103179319, 103928457, 113955320, 127931871, 134358398, 135012773, 137100856, 140098266
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| ChEBI ID |
CHEBI:4784
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| ADReCS Drug ID | BADD_D00767 ; BADD_D02425 | |||
| SuperDrug ATC ID |
C09AA02
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| SuperDrug CAS ID |
cas=075847733
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Enalapril maleate can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -0.335; p = 0.049). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Eubacterium biforme DSM 3989
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Enalapril maleate can be metabolized by Eubacterium biforme DSM 3989 (log2FC = -0.329; p = 0.009). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia hansenii DSM20583
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Enalapril maleate can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.439; p = 0.009). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiotensin-converting enzyme (ACE) | Target Info | Inhibitor | [4] |
| KEGG Pathway | Renin-angiotensin system | |||
| Chagas disease (American trypanosomiasis) | ||||
| Hypertrophic cardiomyopathy (HCM) | ||||
| Pathwhiz Pathway | Angiotensin Metabolism | |||
| Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
| WikiPathways | ACE Inhibitor Pathway | |||
| Metabolism of Angiotensinogen to Angiotensins | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6322). | |||
| REF 2 | New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | Determination of bezafibrate, methotrexate, cyclophosphamide, orlistat and enalapril in waste and surface waters using on-line solid-phase extracti... J Environ Monit. 2009 Apr;11(4):830-8. | |||
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