Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01XBA
|
|||
| Former ID |
DIB013176
|
|||
| Drug Name |
Raloxifene
|
|||
| Synonyms |
Raloxifene (extended-release, CDT)
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Osteoporosis [ICD-11: FB83.0; ICD-10: M85.8] | Approved | [1] | |
| Company |
SCOLR Pharma Inc
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C28H27NO4S
|
|||
| Canonical SMILES |
C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
|
|||
| InChI |
1S/C28H27NO4S/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29/h4-13,18,30-31H,1-3,14-17H2
|
|||
| InChIKey |
GZUITABIAKMVPG-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 84449-90-1
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
9437, 831017, 5392969, 7890214, 7980482, 8153100, 11111733, 11111734, 11364773, 11367335, 11369897, 11372937, 11375497, 11378062, 11466890, 11468010, 11486560, 14834427, 24277274, 26705265, 29224106, 46506514, 46519463, 47213213, 47365304, 47662399, 47810849, 47810850, 48035235, 48185088, 48259344, 48416509, 49698670, 50065297, 50105675, 50139488, 50898374, 53788657, 56310724, 56312953, 56313701, 56352882, 56427219, 57322575, 90341181, 91148450, 92308782, 93165668, 93166953, 96025151
|
|||
| ChEBI ID |
CHEBI:8772
|
|||
| ADReCS Drug ID | BADD_D01903 ; BADD_D01904 | |||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
|
Studied Microbe: Bacteroides uniformis
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Raloxifene hydrochloride (adjusted p-values: 3.43E-03). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620). | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.