Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02OZY
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| Former ID |
DAP000675
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| Drug Name |
Metharbital
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| Synonyms |
Endiemal; Endiemalum; Gemonal; Gemonil; Gemonit; Metabarbital; Metarbital; Metarbitale; Methabarbital; Methabarbitone; Metharbitalum; Metharbitone; Metharbutal; Methylbarbital; Metarbitale [DCIT]; AN 23; Sch 412; Gemonil (TN); Metarbital [INN-Spanish]; Metharbital [INN:JAN]; Metharbitalum [INN-Latin]; N-Methylbarbital; Metharbital (JAN/INN); 1-Methylbarbital; 5,5-Diethyl-1-methyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 5,5-Diethyl-1-methylbarbituric acid; 5,5-diethyl-1-methyl-1,3-diazinane-2,4,6-trione; 5,5-diethyl-1-methylpyrimidine-2,4,6(1H,3H,5H)-trione
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| Drug Type |
Small molecular drug
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| Indication | Epilepsy [ICD-11: 8A60-8A68] | Approved | [1], [2] | |
| Therapeutic Class |
Anticonvulsants
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| Company |
Abbott Laboratories
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| Structure |
 |
Download2D MOL |
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| Formula |
C9H14N2O3
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| Canonical SMILES |
CCC1(C(=O)NC(=O)N(C1=O)C)CC
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| InChI |
1S/C9H14N2O3/c1-4-9(5-2)6(12)10-8(14)11(3)7(9)13/h4-5H2,1-3H3,(H,10,12,14)
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| InChIKey |
FWJKNZONDWOGMI-UHFFFAOYSA-N
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| CAS Number |
CAS 50-11-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
87762, 5065190, 7848445, 8152571, 10524269, 15219977, 29223208, 46508167, 48416239, 49874134, 50125862, 57322141, 71931286, 75934082, 103165910, 104305425, 125823562, 127909218, 132522175, 134337964, 134971003, 137004936, 140085464, 144206305, 160963809, 163263703, 164845527, 177513113, 178103804, 179116777, 198967192, 226458080, 249543436, 250037661, 252351626
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| ChEBI ID |
CHEBI:31827
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| SuperDrug ATC ID |
N03AA30
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| SuperDrug CAS ID |
cas=000050113
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor gamma-3 (GABRG3) | Target Info | Modulator | [3] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7230). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 008322. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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