Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03SXE
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| Drug Name |
Betamethasone Valerate
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| Synonyms |
Beta-val; Betaderm; Betatrex; Dermabet; Valnac
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| Drug Type |
Small molecular drug
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| Indication | Dermatological disease [ICD-11: DA24.Y] | Approved | [1] | |
| Company |
Schering Corp Sub Schering Plough Corp
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| Structure |
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Download2D MOL |
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| Formula |
C27H37FO6
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| Canonical SMILES |
CCCCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CO
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| InChI |
1S/C27H37FO6/c1-5-6-7-23(33)34-27(22(32)15-29)16(2)12-20-19-9-8-17-13-18(30)10-11-24(17,3)26(19,28)21(31)14-25(20,27)4/h10-11,13,16,19-21,29,31H,5-9,12,14-15H2,1-4H3/t16-,19-,20-,21-,24-,25-,26-,27-/m0/s1
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| InChIKey |
SNHRLVCMMWUAJD-SUYDQAKGSA-N
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| CAS Number |
CAS 2152-44-5
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:31277
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| ADReCS Drug ID | BADD_D00262 | |||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides eggerthii DSM20697
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone valerate can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -0.701; p = 0.05). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone valerate can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.629; p = 0.028). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone valerate can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.573; p = 0.039). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone valerate can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -0.548; p = 0.023). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone valerate can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -0.329; p = 0.017). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone valerate can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -0.491; p = 0.03). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone valerate can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.83; p = 0.006). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone valerate can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -0.734; p = 0.009). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone valerate can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -0.588; p = 0.021). | |||
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Studied Microbe: Odoribacter splanchnicus
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone valerate can be metabolized by Odoribacter splanchnicus (log2FC = -0.799; p = 0.007). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone valerate can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -0.483; p = 0.039). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta ATCC 25559
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone valerate can be metabolized by Eggerthella lenta ATCC 25559 (log2FC = -0.709; p = 0.008). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Escherichia coli BW25113
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone valerate can be metabolized by Escherichia coli BW25113 (log2FC = -0.502; p = 0.027). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia hansenii DSM20583
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone valerate can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.748; p = 0.02). | |||
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Studied Microbe: Clostridium sp.
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone valerate can be metabolized by Clostridium sp. (log2FC = -0.795; p = 0.019). | |||
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Studied Microbe: Subdoligranulum variabile DSM 15176
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone valerate can be metabolized by Subdoligranulum variabile DSM 15176 (log2FC = -0.448; p = 0.037). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
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Studied Microbe: Victivallis vadensis ATCC BAA-548
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Betamethasone valerate can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -0.535; p = 0.027). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucocorticoid receptor (NR3C1) | Target Info | Modulator | [3] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | |||
| Signaling events mediated by HDAC Class II | ||||
| FOXA2 and FOXA3 transcription factor networks | ||||
| Glucocorticoid receptor regulatory network | ||||
| Regulation of Androgen receptor activity | ||||
| AP-1 transcription factor network | ||||
| Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | |||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | |||
| SIDS Susceptibility Pathways | ||||
| Nuclear Receptors Meta-Pathway | ||||
| Endoderm Differentiation | ||||
| Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | ||||
| Adipogenesis | ||||
| Circadian Clock | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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