Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06NSA
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| Former ID |
DAP000684
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| Drug Name |
Thiamylal
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| Synonyms |
Surital; Thioquinalbarbitone; Thioseconal; Thiamylal [USAN]; Surital (TN); Barbituric acid, 5-allyl-5-(1-methylbutyl)-2-thio-(VAN); Barbituric acid, 5-allyl-5-(1-methylbutyl)-2-thio-(VAN) (8CI); Dihydro-5-(1-methylbutyl)-5-(2-propenyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione; Dihydro-5-(1-methylbutyl)-5-(2-propenyl)-2-thioxo-4,6-(1H,5H)-pyrimidinedione; 4,6(1H,5H)-Pyrimidinedione, dihydro-5-(1-methylbutyl)-5-(2-propenyl)-2-thioxo-(9CI); 5-(pentan-2-yl)-5-(prop-2-en-1-yl)-2-sulfanylidenedihydropyrimidine-4,6(1H,5H)-dione; 5-Allyl-5-(1-methylbutyl)-2-thiobarbituric acid; 5-Allyl-5-(1-methylbutyl)-2-thiobarbitursaeure; 5-Allyl-5-(1-methylbutyl)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione; 5-allyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione; 5-pentan-2-yl-5-prop-2-enyl-2-sulfanylidene-1,3-diazinane-4,6-dione
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| Drug Type |
Small molecular drug
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| Indication | Anaesthesia [ICD-11: 9A78.6; ICD-9: 338] | Approved | [1], [2] | |
| Therapeutic Class |
Hypnotics and Sedatives
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| Structure |
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Download2D MOL |
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| Formula |
C12H18N2O2S
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| Canonical SMILES |
CCCC(C)C1(C(=O)NC(=S)NC1=O)CC=C
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| InChI |
1S/C12H18N2O2S/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17)
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| InChIKey |
XLOMZPUITCYLMJ-UHFFFAOYSA-N
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| CAS Number |
CAS 77-27-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10048, 415165, 4984465, 10047163, 10535516, 11336165, 11361404, 11364718, 11367280, 11369842, 11372902, 11374153, 11378006, 11462376, 11484303, 11488200, 11491597, 11492392, 11495626, 11533350, 14847827, 24900605, 36076551, 46506261, 47207764, 47662378, 48035218, 48110530, 50065188, 50920492, 57352618, 57654714, 81065588, 85787996, 103165645, 111631835, 117425385, 129706261, 134337973, 134972312, 137101017, 137241738, 160964488, 164788465, 178103878, 179039353, 179225380, 184546708, 226856989, 238005100
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| ChEBI ID |
CHEBI:9536
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor gamma-3 (GABRG3) | Target Info | Modulator | [3] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7305). | |||
| REF 2 | Drug information of Thiamylal, 2008. eduDrugs. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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