Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07VBA
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| Drug Name |
Estradiol Valerate
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| Synonyms |
Delestrogen
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| Drug Type |
Small molecular drug
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| Indication | Hormone replacement therapy [ICD-11: 8E01; ICD-10: Z79.890; ICD-9: V07.4] | Approved | [1] | |
| Company |
Par Sterile Products Llc
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| Structure |
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Download2D MOL |
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| Formula |
C23H32O3
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| Canonical SMILES |
CCCCC(=O)OC1CCC2C1(CCC3C2CCC4=C3C=CC(=C4)O)C
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| InChI |
1S/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3/t18-,19-,20+,21+,23+/m1/s1
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| InChIKey |
RSEPBGGWRJCQGY-RBRWEJTLSA-N
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| CAS Number |
CAS 979-32-8
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:31561
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| ADReCS Drug ID | BADD_D00825 | |||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
|
Studied Microbe: Bacteroides caccae
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides caccae was decreased by Estradiol Valerate (adjusted p-values: 4.32E-03). | |||
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Studied Microbe: Bacteroides fragilis enterotoxigenic
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis enterotoxigenic was decreased by Estradiol Valerate (adjusted p-values: 6.65E-03). | |||
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Studied Microbe: Bacteroides fragilis nontoxigenic
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis nontoxigenic was decreased by Estradiol Valerate (adjusted p-values: 8.97E-05). | |||
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Studied Microbe: Bacteroides vulgatus
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Estradiol Valerate (adjusted p-values: 8.16E-06). | |||
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Studied Microbe: Parabacteroides merdae
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides merdae was decreased by Estradiol Valerate (adjusted p-values: 9.98E-04). | |||
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Studied Microbe: Prevotella copri
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Prevotella copri was decreased by Estradiol Valerate (adjusted p-values: 7.43E-03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Clostridium perfringens
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridium perfringens was decreased by Estradiol Valerate (adjusted p-values: 1.48E-03). | |||
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Studied Microbe: Coprococcus comes
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Estradiol Valerate (adjusted p-values: 2.00E-04). | |||
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Studied Microbe: Eubacterium rectale
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Estradiol Valerate (adjusted p-values: 2.44E-03). | |||
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Studied Microbe: Ruminococcus bromii
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus bromii was decreased by Estradiol Valerate (adjusted p-values: 1.73E-04). | |||
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Studied Microbe: Ruminococcus torques
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|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus torques was decreased by Estradiol Valerate (adjusted p-values: 5.75E-04). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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