Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09GFL
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| Former ID |
DAP001122
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| Drug Name |
Trihexyphenidyl
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| Synonyms |
trihexyphenidyl; Benzhexol; Triphenidyl; Trihexyphenidyle; Parkinane retard; Benzhexolum; 144-11-6; Trihexyphenidylum; Sedrena (free base); Trihexifenidilo; Trihexyphenidyle [INN-French]; Trihexifenidilo [INN-Spanish]; Trihexyphenidylum [INN-Latin]; Artane; Trihexylphenizyl; Trihexylphenidyl; Trihexylphenidyle; Trihexyphenidyl [INN:BAN]; Trihexylphenedyl; HSDB 3196; EINECS 205-614-4; NSC 12268; 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-; 1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol; BRN 0088959; Benzhexol; Trihexane; Trihexy; Artane Sequels; PMS Trihexyphenidyl; Apo-Trihex; Artane (TN); Trihexyphenidyl (INN); Apo-Trihex (TN); Apo-trihex (TN); SWR-0342SA
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| Drug Type |
Small molecular drug
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| Indication | Dystonia [ICD-11: 8A02] | Approved | [1], [2], [3] | |
| Parkinson disease [ICD-11: 8A00.0] | Approved | [1], [2], [3] | ||
| Obesity [ICD-11: 5B81; ICD-10: E66; ICD-9: 278] | Investigative | [4] | ||
| Therapeutic Class |
Antiparkinson Agents
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| Company |
Lederle Laboratories Div American Cyanamid Co
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| Structure |
 |
Download2D MOL |
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| Formula |
C20H31NO
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| Canonical SMILES |
C1CCC(CC1)C(CCN2CCCCC2)(C3=CC=CC=C3)O
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| InChI |
1S/C20H31NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2
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| InChIKey |
HWHLPVGTWGOCJO-UHFFFAOYSA-N
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| CAS Number |
CAS 144-11-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9380, 76985, 5664292, 7978767, 8153428, 10508113, 11335547, 11360786, 11363526, 11366088, 11368650, 11372249, 11373976, 11376812, 11461758, 11466729, 11467849, 11484493, 11486538, 11488645, 11491190, 11492184, 11494446, 14751778, 29224611, 46507717, 47365113, 47515241, 47515242, 47662205, 47662206, 47662207, 47736399, 48110381, 48259153, 48416664, 49698895, 50016994, 50105266, 50483190, 57322850, 85209532, 85788388, 90341555, 96025321, 103555930, 104309620, 124750254, 124881579, 124881580
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| ChEBI ID |
CHEBI:9720
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| ADReCS Drug ID | BADD_D02284 ; BADD_D02285 | |||
| SuperDrug ATC ID |
N04AA01
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| SuperDrug CAS ID |
cas=000144116
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides dorei DSM 17855
Show/Hide Hierarchy
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trihexyphenidyl can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.386; p = 0.02). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
Show/Hide Hierarchy
|
[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trihexyphenidyl can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.331; p = 0.045). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium ruminantium
Show/Hide Hierarchy
|
[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trihexyphenidyl can be metabolized by Bifidobacterium ruminantium (log2FC = -0.402; p = 0.013). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia hansenii DSM20583
Show/Hide Hierarchy
|
[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trihexyphenidyl can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.442; p = 0.017). | |||
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Studied Microbe: Clostridium sp.
Show/Hide Hierarchy
|
[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trihexyphenidyl can be metabolized by Clostridium sp. (log2FC = -0.526; p = 0.031). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7315). | |||
| REF 2 | Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 4 | Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21. | |||
| REF 5 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 6 | The role of M1 muscarinic cholinergic receptors in the discriminative stimulus properties of N-desmethylclozapine and the atypical antipsychotic dr... Psychopharmacology (Berl). 2009 Apr;203(2):295-301. | |||
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