Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09IPV
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| Former ID |
DAP001017
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| Drug Name |
Danazol
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| Synonyms |
Anatrol; Chronogyn; Cyclomen; Danatrol; Danazant; Danazole; Danazolum; Danocrine; Danogen; Danokrin; Danol; Danoval; Danzol; Ladogal; Norciden; Panacrine; Winobanin; Alphapharm Brand of Danazol; Antigen Brand of Danazol; Kendrick Brand of Danazol; Ratiopharm Brand of Danazol; Sanofi Brand of Danazol; Sanofi Synthelabo Brand ofDanazol; Sanofi Winthrop Brand of Danazol; WIN 17757; Danazol-ratiopharm; Danazolum [INN-Latin]; Danocrine (TN); WIN 17,757; WIN-17757; Win 17, 757; Danazol (JAN/USP/INN); Danazol [USAN:BAN:INN:JAN];[1,2]oxazolo[4',5':2,3]-17alpha-pregn-4-en-20-yn-17-ol; (1R,3aS,3bR,10aR,10bS,12aS)-1-ethynyl-10a,12a-dimethyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-1H-cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol; (1S,2R,13R,14S,17R,18S)-17-ethynyl-2,18-dimethyl-7-oxa-6-azapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4(8),5,9-trien-17-ol; 1-Ethynyl-10a,12a-dimethyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-1H-cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol; 17-alpha-2,4-Pregnadien-20-yno(2,3-d)isoxazol-17-ol; 17-alpha-Pregn-4-en-20-yno(2,3-d)isoxazol-17-ol; 17-alpha-Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol; 17.Alpha.-Pregna-2, {4-dien-20-yno[2,3-d]isoxazol-17-ol}; 17alpha-Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol
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| Drug Type |
Small molecular drug
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| Indication | Menorrhagia [ICD-11: GA20.50; ICD-9: 627] | Approved | [1], [2] | |
| Breast cancer [ICD-11: 2C60-2C65] | Phase 2 | [1], [3] | ||
| Therapeutic Class |
Fertility Agents
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| Structure |
 |
Download2D MOL |
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| Formula |
C22H27NO2
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| Canonical SMILES |
CC12CCC3C(C1CCC2(C#C)O)CCC4=CC5=C(CC34C)C=NO5
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| InChI |
1S/C22H27NO2/c1-4-22(24)10-8-18-16-6-5-15-11-19-14(13-23-25-19)12-20(15,2)17(16)7-9-21(18,22)3/h1,11,13,16-18,24H,5-10,12H2,2-3H3/t16-,17+,18+,20+,21+,22+/m1/s1
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| InChIKey |
POZRVZJJTULAOH-LHZXLZLDSA-N
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| CAS Number |
CAS 17230-88-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9153, 224349, 7847355, 7979022, 8170371, 10321251, 11466133, 11467253, 11485765, 12161772, 14777802, 14851335, 25632846, 26757819, 34670864, 46506475, 47277002, 47425698, 47945219, 47945220, 48415840, 49648394, 49698347, 50019507, 50085994, 50124387, 51053748, 53786945, 56313739, 56352871, 57310643, 85787851, 92125056, 92309018, 92712533, 103543149, 103913731, 104170055, 104302674, 117391787, 117393544, 121362575, 121362727, 123055285, 124799906, 124893625, 126524663, 126630088, 127346804, 127346805
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| ChEBI ID |
CHEBI:4315
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| ADReCS Drug ID | BADD_D00576 | |||
| SuperDrug ATC ID |
G03XA01
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| SuperDrug CAS ID |
cas=017230885
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes indistinctus DSM22520
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -8.732; p = 0.005). | |||
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Studied Microbe: Bacteroides caccae ATCC 43185
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides caccae ATCC 43185 (log2FC = -10.094; p = 0.01). | |||
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Studied Microbe: Bacteroides cellulosilyticus DSM 14838
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -2.099; p = 0.012). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -4.544; p = 0.0). | |||
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Studied Microbe: Bacteroides eggerthii DSM20697
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -10.012; p = 0.01). | |||
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Studied Microbe: Bacteroides finegoldii DSM17565
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides finegoldii DSM17565 (log2FC = -4.772; p = 0.028). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -7.937; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -8.019; p = 0.004). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -8.655; p = 0.011). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -8.315; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -1.187; p = 0.011). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -9.67; p = 0.005). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -8.352; p = 0.006). | |||
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Studied Microbe: Bacteroides intestinalis DSM 17393
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -1.826; p = 0.001). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -0.81; p = 0.029). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -1.135; p = 0.006). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -0.834; p = 0.015). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -0.758; p = 0.018). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -3.335; p = 0.002). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -6.901; p = 0.003). | |||
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Studied Microbe: Bacteroides WH2
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides WH2 (log2FC = -0.994; p = 0.022). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -7.112; p = 0.003). | |||
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Studied Microbe: Odoribacter splanchnicus
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Odoribacter splanchnicus (log2FC = -8.857; p = 0.003). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -4.035; p = 0.004). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -4.139; p = 0.0). | |||
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Studied Microbe: Parabacteroides merdae ATCC 43184
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -1.594; p = 0.019). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Pretovella copri DSM 18205 (log2FC = -6.493; p = 0.002). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium adolescentis ATCC 15703
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bifidobacterium adolescentis ATCC 15703 (log2FC = -0.686; p = 0.015). | |||
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Studied Microbe: Bifidobacterium breve DSM 20213
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bifidobacterium breve DSM 20213 (log2FC = -6.68; p = 0.026). | |||
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Studied Microbe: Bifidobacterium longum subsp. Infantis CCUG52486
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bifidobacterium longum subsp. Infantis CCUG52486 (log2FC = -5.48; p = 0.01). | |||
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Studied Microbe: Bifidobacterium ruminantium
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bifidobacterium ruminantium (log2FC = -4.617; p = 0.005). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens ATCC25986
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Collinsella aerofaciens ATCC25986 (log2FC = -6.527; p = 0.01). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta ATCC 25559
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Eggerthella lenta ATCC 25559 (log2FC = -8.917; p = 0.005). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Edwardsiella tarda ATCC 23685
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Edwardsiella tarda ATCC 23685 (log2FC = -8.35; p = 0.005). | |||
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Studied Microbe: Enterobacter cancerogenus ATCC35316
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Enterobacter cancerogenus ATCC35316 (log2FC = -7.995; p = 0.004). | |||
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Studied Microbe: Escherichia coli BW25113
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Escherichia coli BW25113 (log2FC = -9.667; p = 0.004). | |||
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Studied Microbe: Proteus penneri ATCC 35198
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Proteus penneri ATCC 35198 (log2FC = -6.912; p = 0.003). | |||
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Studied Microbe: Providencia alcalifaciens DSM 30120
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Providencia alcalifaciens DSM 30120 (log2FC = -8.442; p = 0.003). | |||
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Studied Microbe: Providencia rettgeri DSM 1131
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Providencia rettgeri DSM 1131 (log2FC = -7.285; p = 0.001). | |||
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Studied Microbe: Providencia stuartii ATCC 25827
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Providencia stuartii ATCC 25827 (log2FC = -3.165; p = 0.002). | |||
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Studied Microbe: Salmonella typhimurium LT2
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Salmonella typhimurium LT2 (log2FC = -8.772; p = 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Clostridium ramosum DSM 1402
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Clostridium ramosum DSM 1402 (log2FC = -9.29; p = 0.002). | |||
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Studied Microbe: Clostridium spiroforme DSM1552
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Clostridium spiroforme DSM1552 (log2FC = -7.416; p = 0.005). | |||
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Studied Microbe: Eubacterium biforme DSM 3989
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Eubacterium biforme DSM 3989 (log2FC = -8.232; p = 0.014). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Anaerostipes sp.
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Anaerostipes sp. (log2FC = -6.848; p = 0.017). | |||
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Studied Microbe: Anaerotruncus colihominis DSM 17241
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Anaerotruncus colihominis DSM 17241 (log2FC = -10.254; p = 0.021). | |||
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Studied Microbe: Bacteroides pectinophilus ATCC 43243
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bacteroides pectinophilus ATCC 43243 (log2FC = -4.009; p = 0.015). | |||
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Studied Microbe: Blautia hansenii DSM20583
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Blautia hansenii DSM20583 (log2FC = -9.172; p = 0.014). | |||
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Studied Microbe: Blautia luti DSM 14534
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Blautia luti DSM 14534 (log2FC = -9.181; p = 0.002). | |||
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Studied Microbe: Bryantia formatexigens DSM 14469
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Bryantia formatexigens DSM 14469 (log2FC = -7.465; p = 0.008). | |||
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Studied Microbe: Clostridium difficile 120
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Clostridium difficile 120 (log2FC = -8.789; p = 0.01). | |||
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Studied Microbe: Clostridium hathewayi DSM 13479
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Clostridium hathewayi DSM 13479 (log2FC = -7.834; p = 0.005). | |||
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Studied Microbe: Clostridium scindens ATCC 35704
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Clostridium scindens ATCC 35704 (log2FC = -6.742; p = 0.006). | |||
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Studied Microbe: Clostridium sp.
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Clostridium sp. (log2FC = -8.539; p = 0.036). | |||
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Studied Microbe: Clostridium sporogenes ATCC 15579
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Clostridium sporogenes ATCC 15579 (log2FC = -9.43; p = 0.007). | |||
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Studied Microbe: Clostridium symbiosum ATCC 14940
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Clostridium symbiosum ATCC 14940 (log2FC = -6.624; p = 0.005). | |||
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Studied Microbe: Coprococcus comes ATCC 27758
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Coprococcus comes ATCC 27758 (log2FC = -10.212; p = 0.002). | |||
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Studied Microbe: Dorea formicigenerans ATCC 27755
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Dorea formicigenerans ATCC 27755 (log2FC = -6.388; p = 0.005). | |||
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Studied Microbe: Enterocloster bolteae ATCC BAA-613
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Enterocloster bolteae ATCC BAA-613 (log2FC = -7.623; p = 0.002). | |||
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Studied Microbe: Eubacterium rectale ATCC 33656
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Eubacterium rectale ATCC 33656 (log2FC = -7.247; p = 0.01). | |||
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Studied Microbe: Eubacterium ventriosum ATCC 27560
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Eubacterium ventriosum ATCC 27560 (log2FC = -5.913; p = 0.004). | |||
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Studied Microbe: Roseburia intestinalis L1-82
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Roseburia intestinalis L1-82 (log2FC = -8.454; p = 0.014). | |||
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Studied Microbe: Ruminococcus gnavus ATCC 29149
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Ruminococcus gnavus ATCC 29149 (log2FC = -8.805; p = 0.01). | |||
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Studied Microbe: Ruminococcus lactaris ATCC 29176
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Ruminococcus lactaris ATCC 29176 (log2FC = -7.237; p = 0.002). | |||
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Studied Microbe: Ruminococcus torques ATCC 27756
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Ruminococcus torques ATCC 27756 (log2FC = -7.371; p = 0.01). | |||
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Studied Microbe: Subdoligranulum variabile DSM 15176
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Subdoligranulum variabile DSM 15176 (log2FC = -8.019; p = 0.004). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Enterococcus faecalis V583
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Enterococcus faecalis V583 (log2FC = -8.818; p = 0.01). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Tissierellales | ||||
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Studied Microbe: Anaerococcus hydrogenalis DSM 7454
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Anaerococcus hydrogenalis DSM 7454 (log2FC = -8.318; p = 0.02). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia muciniphila ATCC BAA-835
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Akkermansia muciniphila ATCC BAA-835 (log2FC = -8.506; p = 0.005). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
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Studied Microbe: Victivallis vadensis ATCC BAA-548
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Danazol can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -8.995; p = 0.011). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6942). | |||
| REF 2 | Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 4 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 5 | Danazol suppression of luteinizing hormone in the rat: evidence for mediation by both androgen and estrogen receptors. Proc Soc Exp Biol Med. 1990 May;194(1):54-7. | |||
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