Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09WYX
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| Former ID |
DNAP001529
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| Drug Name |
Deflazacort
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| Synonyms |
C25H33NO6; Deflazacort (Calcort); Deflazacortum [INN-Latin]; EINECS 238-483-7; Deflan (TN); D09WYX; AC1L1BQ2; Deflazacort [USAN:BAN:INN]; CTK8F9001; MolPort-035-394-927
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| Drug Type |
Small molecular drug
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| Indication | Duchenne dystrophy [ICD-11: 8C70; ICD-10: G71.0] | Approved | [1], [2], [3], [4] | |
| Company |
PTC Therapeutics
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| Structure |
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Download2D MOL |
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| Formula |
C25H31NO6
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| Canonical SMILES |
CC1=NC2(C(O1)CC3C2(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)C(=O)COC(=O)C
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| InChI |
1S/C25H31NO6/c1-13-26-25(20(30)12-31-14(2)27)21(32-13)10-18-17-6-5-15-9-16(28)7-8-23(15,3)22(17)19(29)11-24(18,25)4/h7-9,17-19,21-22,29H,5-6,10-12H2,1-4H3/t17-,18-,19-,21+,22+,23-,24-,25+/m0/s1
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| InChIKey |
FBHSPRKOSMHSIF-GRMWVWQJSA-N
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| CAS Number |
CAS 14484-47-0
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:135720
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| ADReCS Drug ID | BADD_D02492 | |||
| SuperDrug ATC ID |
H02AB13
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| Interaction between the Drug and Microbe | Top | |||
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| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes indistinctus DSM22520
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Alistipes indistinctus DSM22520 (log2FC = -0.878; p = 0.026). | |||
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Studied Microbe: Bacteroides caccae ATCC 43185
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bacteroides caccae ATCC 43185 (log2FC = -0.863; p = 0.003). | |||
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Studied Microbe: Bacteroides cellulosilyticus DSM 14838
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -3.084; p = 0.001). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -7.773; p = 0.012). | |||
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Studied Microbe: Bacteroides eggerthii DSM20697
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -0.667; p = 0.039). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -0.926; p = 0.013). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.797; p = 0.01). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.785; p = 0.006). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -0.516; p = 0.018). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.786; p = 0.02). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -0.815; p = 0.006). | |||
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Studied Microbe: Bacteroides intestinalis DSM 17393
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bacteroides intestinalis DSM 17393 (log2FC = -0.495; p = 0.026). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -9.231; p = 0.003). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -1.262; p = 0.012). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -1.321; p = 0.004). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -1.315; p = 0.013). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -11.27; p = 0.004). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -10.485; p = 0.002). | |||
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Studied Microbe: Bacteroides WH2
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bacteroides WH2 (log2FC = -3.913; p = 0.005). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -11.272; p = 0.002). | |||
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Studied Microbe: Odoribacter splanchnicus
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Odoribacter splanchnicus (log2FC = -0.776; p = 0.0). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -0.475; p = 0.005). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -0.916; p = 0.002). | |||
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Studied Microbe: Parabacteroides merdae ATCC 43184
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -0.643; p = 0.006). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Pretovella copri DSM 18205 (log2FC = -9.073; p = 0.001). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium ruminantium
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Bifidobacterium ruminantium (log2FC = -0.392; p = 0.009). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia hansenii DSM20583
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.519; p = 0.026). | |||
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Studied Microbe: Clostridium sp.
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Clostridium sp. (log2FC = -0.458; p = 0.016). | |||
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Studied Microbe: Eubacterium rectale ATCC 33656
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Eubacterium rectale ATCC 33656 (log2FC = -0.389; p = 0.007). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Victivallales | ||||
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Studied Microbe: Victivallis vadensis ATCC BAA-548
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[5] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Deflazacort can be metabolized by Victivallis vadensis ATCC BAA-548 (log2FC = -2.852; p = 0.001). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucocorticoid receptor (NR3C1) | Target Info | Modulator | [6] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | |||
| Signaling events mediated by HDAC Class II | ||||
| FOXA2 and FOXA3 transcription factor networks | ||||
| Glucocorticoid receptor regulatory network | ||||
| Regulation of Androgen receptor activity | ||||
| AP-1 transcription factor network | ||||
| Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | |||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | |||
| SIDS Susceptibility Pathways | ||||
| Nuclear Receptors Meta-Pathway | ||||
| Endoderm Differentiation | ||||
| Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | ||||
| Adipogenesis | ||||
| Circadian Clock | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | ClinicalTrials.gov (NCT01817322) Kidney Graft Function Under the Immunosuppression Strategies. U.S. National Institutes of Health. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2018 | |||
| REF 4 | 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. | |||
| REF 5 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 6 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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