Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0A5LH
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| Drug Name |
Penicillin G Procaine
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| Synonyms |
Duracillin A.S.; Pfizerpen-as
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Approved | [1] | |
| Therapeutic Class |
Antiinfective Agents
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| Company |
Eli Lilly And Co
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| Structure |
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Download2D MOL
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| Formula |
C29H40N4O7S
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| Canonical SMILES |
CCN(CC)CCOC(=O)C1=CC=C(C=C1)N.CC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)O)C.O
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| InChI |
1S/C16H18N2O4S.C13H20N2O2.H2O/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);5-8H,3-4,9-10,14H2,1-2H3;1H2/t11-,12+,14-;;/m1../s1
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| InChIKey |
KZDCMKVLEYCGQX-UDPGNSCCSA-N
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| CAS Number |
CAS 6130-64-9
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| PubChem Compound ID | ||||
| ADReCS Drug ID | BADD_D01713 ; BADD_D02478 | |||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
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Studied Microbe: Firmicutes/Bacteroidetes ratio
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | C57BL/6J mice | Experimental Sample | Cecal content | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Firmicutes/Bacteroidetes ratio was increased by Combination of penicillin G and erythromycin. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial Penicillin binding protein (Bact PBP) | Target Info | Modulator | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | From the Cover: Exposure to Oral Antibiotics Induces Gut Microbiota Dysbiosis Associated with Lipid Metabolism Dysfunction and Low-Grade Inflammation in Mice. Toxicol Sci. 2016 Nov;154(1):140-152. | |||
| REF 3 | Bacterial Resistance to Penicillin G by Decreased Affinity of Penicillin-Binding Proteins: A Mathematical Model | |||
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