Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0AC2H
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| Former ID |
DIB020085
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| Drug Name |
isonipecotic acid
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| Synonyms |
Isonipecotic acid; Piperidine-4-carboxylic acid; 498-94-2; 4-Piperidinecarboxylic acid; 4-Carboxypiperidine; Hexahydroisonicotinic acid; h-inp-oh; dl-isopipecolinic acid; Isonicotinic acid, hexahydro-; Acide isonipecotique; 4-Hexahydroisonicotinic acid; NSC 61049; UNII-M5TZP1RWIE; iso-nipecotic acid; Acide isonipecotique [French]; Acide piperidine-carboxylique-4; M5TZP1RWIE; EINECS 207-872-3; BRN 0112553; 4-Piperidine carboxylic acid; Acide piperidine-carboxylique-4 [French]; CHEMBL279998; SRJOCJYGOFTFLH-UHFFFAOYSA-N
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C6H11NO2
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| Canonical SMILES |
C1CNCCC1C(=O)O
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| InChI |
1S/C6H11NO2/c8-6(9)5-1-3-7-4-2-5/h5,7H,1-4H2,(H,8,9)
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| InChIKey |
SRJOCJYGOFTFLH-UHFFFAOYSA-N
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| CAS Number |
CAS 498-94-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
108908, 3133581, 5621709, 8139887, 8152387, 11111343, 15114452, 17405266, 24278166, 24887575, 29200595, 29222892, 48259445, 49829676, 49986082, 50105710, 50105711, 51074881, 53777811, 57321988, 57636349, 76425231, 81041458, 85087068, 85231096, 87571621, 87623723, 90341183, 92304064, 103179764, 103914803, 104304478, 104667281, 117609573, 117650612, 117688725, 118053598, 121361695, 124749931, 124880480, 124880481, 125003175, 125321689, 125351469, 126557591, 126579288, 126588515, 126607407, 126614636, 126616726
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-2 (GABRA2) | Target Info | Agonist | [3] |
| GABA(A) receptor alpha-3 (GABRA3) | Target Info | Agonist | [4] | |
| GABA(A) receptor alpha-5 (GABRA5) | Target Info | Agonist | [5] | |
| GABA(A) receptor gamma-3 (GABRG3) | Target Info | Agonist | [6] | |
| GABA(A) receptor rho1 (GABRR1) | Target Info | Antagonist | [7] | |
| GABA(A) receptor rho2 (GABRR2) | Target Info | Antagonist | [8] | |
| GABA(A) receptor rho3 (GABRR3) | Target Info | Antagonist | [9] | |
| Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||
| Iron uptake and transport | ||||
| SIDS Susceptibility Pathways | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4227). | |||
| REF 2 | Hydroxy- and amino-substituted piperidinecarboxylic acids as gamma-aminobutyric acid agonists and uptake inhibitors. J Med Chem. 1982 Oct;25(10):1157-62. | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 405). | |||
| REF 4 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 406). | |||
| REF 5 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). | |||
| REF 6 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). | |||
| REF 7 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 420). | |||
| REF 8 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 421). | |||
| REF 9 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 422). | |||
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