Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0C1SF
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| Former ID |
DAP000539
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| Drug Name |
Griseofulvin
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| Synonyms |
Amudane; Delmofulvina; Fulcin; Fulcine; Fulvicin; FulvicinUF; Fulvina; Fulvinil; Fulvistatin; Fungivin; Greosin;Gresfeed; Gricin; Grifulin; Grifulvin; GrisPEG; Grisactin; Griscofulvin; Grisefuline; Griseo; Griseofulvina; Griseofulvine; Griseofulvinum; Griseomix; Griseostatin; Grisetin; Grisofulvin; Grisovin; Grizeofulvin; Grysio; Guservin; Lamoryl; Likuden; Likunden; Murfulvin; Poncyl; Spirofulvin; Sporostatin; Xuanjing; Curling fact or; Curling factor; Fulvican grisactin; Fulvicin U F; Grifulvin V; Gris PEG; Grisactin Ultra; Grise ostatin; Griseofulvin forte; Grisovin FP; Interacts with polymerized microtubules and associated proteins; Sporostatin xan; Biogrisin-FP; FULVICIN P/G 165; FULVICIN P/G 330;Fulvicin Bolus (Veterinary); Fulvicin P/G; Fulvicin U/F; Fulvidex (Veterinary); GRISEOFULVIN, MICROCRYSTALLINE; GRISEOFULVIN, ULTRAMICROCRYSTALLINE; Gris-PEG; Griseofulvin and Alpha-IFN; Griseofulvin-forte; Griseofulvina [INN-Spanish]; Griseofulvine [INN-French]; Griseofulvinum [INN-Latin]; Grisovin (TN); NP-002466; Neo-Fulcin; ULTRAGRIS-165; ULTRAGRIS-330; USAF SC-2; Fulvicin-P/G; Fulvicin-U-F; Fulvicin-U/F; Fulvicin-U/F (Veterinary); Griseofulvin [USAN:INN:BAN:JAN]; (+)-Griseofulvin; 7-Chloro-4,6,2'-trimethoxy-6'-methylgris-2'-en-3,4'-dione
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| Drug Type |
Small molecular drug
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| Indication | Ringworm infection [ICD-11: 1F28; ICD-10: B35, B36; ICD-9: 110] | Approved | [1], [2] | |
| Therapeutic Class |
Antifungal Agents
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| Structure |
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Download2D MOL |
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| Formula |
C17H17ClO6
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| Canonical SMILES |
CC1CC(=O)C=C(C12C(=O)C3=C(O2)C(=C(C=C3OC)OC)Cl)OC
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| InChI |
1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1
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| InChIKey |
DDUHZTYCFQRHIY-RBHXEPJQSA-N
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| CAS Number |
CAS 126-07-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
8911, 603057, 1240856, 3139652, 7847276, 7979462, 8149360, 10298748, 10321345, 11335329, 11341607, 11360568, 11361790, 11363710, 11366272, 11368834, 11371221, 11374592, 11376996, 11461540, 11483961, 11487192, 11488029, 11489977, 11492742, 11494630, 11537460, 14778634, 15026839, 17389865, 24869893, 24895099, 24895185, 26613001, 26680363, 26747301, 26747302, 29204198, 36885045, 46508437, 47216648, 47291003, 47736332, 47810614, 47959588, 48034972, 48110318, 48184863, 48259080, 48413831
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| ChEBI ID |
CHEBI:27779
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| ADReCS Drug ID | BADD_D01042 | |||
| SuperDrug ATC ID |
D01AA08; D01BA01
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| SuperDrug CAS ID |
cas=000126078
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides dorei DSM 17855
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Griseofulvin can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.69; p = 0.039). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Griseofulvin can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -0.778; p = 0.017). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Griseofulvin can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.585; p = 0.028). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Griseofulvin can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -0.721; p = 0.018). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Griseofulvin can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -0.588; p = 0.029). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Griseofulvin can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.609; p = 0.038). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Griseofulvin can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -0.666; p = 0.037). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Griseofulvin can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -0.419; p = 0.03). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Griseofulvin can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.76; p = 0.016). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Griseofulvin can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -0.782; p = 0.025). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Griseofulvin can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -0.54; p = 0.007). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Griseofulvin can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -0.503; p = 0.024). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Fungal Microtubule (Fung MicroTU) | Target Info | Inducer | [4], [5] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality. Ther Clin Risk Manag. 2005 Dec;1(4):299-306. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | Dermatophyte infections. Am Fam Physician. 2003 Jan 1;67(1):101-8. | |||
| REF 5 | Formation of Mallory body-like inclusions and cell death induced by deregulated expression of keratin 18. Mol Biol Cell. 2002 Oct;13(10):3441-51. | |||
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