Drug Information
Drug General Information | Top | |||
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Drug ID |
D0DH1H
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Former ID |
DIB015527
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Drug Name |
CCT-241533
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Synonyms |
Chk2 inhibitors (cancer); Chk2 inhibitors (cancer), Cancer Research Technology
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Drug Type |
Small molecular drug
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Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Investigative | [1] | |
Company |
Cancer Research Technology Ltd
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Structure |
Download2D MOL |
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Formula |
C23H27FN4O4
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Canonical SMILES |
CC(C)(C1CNCC1NC2=NC(=NC3=CC(=C(C=C32)OC)OC)C4=C(C=CC(=C4)F)O)O
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InChI |
1S/C23H27FN4O4/c1-23(2,30)15-10-25-11-17(15)27-21-13-8-19(31-3)20(32-4)9-16(13)26-22(28-21)14-7-12(24)5-6-18(14)29/h5-9,15,17,25,29-30H,10-11H2,1-4H3,(H,26,27,28)/t15-,17-/m1/s1
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InChIKey |
HZASIAXCPXTISQ-NVXWUHKLSA-N
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CAS Number |
CAS 1262849-73-9
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Serine/threonine-protein kinase Chk2 (RAD53) | Target Info | Inhibitor | [2] |
KEGG Pathway | Cell cycle | |||
p53 signaling pathway | ||||
HTLV-I infection | ||||
Pathway Interaction Database | ATM pathway | |||
FOXM1 transcription factor network | ||||
p53 pathway | ||||
PLK3 signaling events | ||||
Reactome | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks | |||
G2/M DNA damage checkpoint | ||||
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | ||||
WikiPathways | DNA Damage Response | |||
ATM Signaling Pathway | ||||
Integrated Pancreatic Cancer Pathway | ||||
Prostate Cancer | ||||
Integrated Breast Cancer Pathway | ||||
Integrated Cancer pathway | ||||
Cell Cycle | ||||
miRNA Regulation of DNA Damage Response |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8044). | |||
REF 2 | CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors. Cancer Res. 2011 Jan 15;71(2):463-72. |
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