Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0F8KE
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| Drug Name |
Imidazole benzamide derivative 1
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| Synonyms |
PMID28627961-Compound-21
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| Drug Type |
Small molecular drug
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| Indication | Knee pain [ICD-11: ME82; ICD-10: M25.5] | Patented | [1] | |
| Company |
ELI LILLY AND COMPANY HUGHES, Norman Earle WOODS, Timothy Andrew NORMAN, Bryan Hurst
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| Structure |
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Download2D MOL |
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| Formula |
C23H22F5N5O2
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| Canonical SMILES |
CC1=C(N=C(N1)NC(=O)C2=C(N=CC(=C2)CNC(=O)C(C)C)C(F)F)C3=CC=C(C=C3)C(F)(F)F
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| InChI |
1S/C23H22F5N5O2/c1-11(2)20(34)30-10-13-8-16(18(19(24)25)29-9-13)21(35)33-22-31-12(3)17(32-22)14-4-6-15(7-5-14)23(26,27)28/h4-9,11,19H,10H2,1-3H3,(H,30,34)(H2,31,32,33,35)
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| InChIKey |
BZYSILFNUIGABU-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Prostaglandin E synthase (PTGES) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Prostaglandin E synthase (PTGES) | Target's Patent Info | [1] | |
| BioCyc | C20 prostanoid biosynthesis | |||
| KEGG Pathway | Arachidonic acid metabolism | |||
| Metabolic pathways | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| Pathwhiz Pathway | Arachidonic Acid Metabolism | |||
| WikiPathways | Arachidonic acid metabolism | |||
| Eicosanoid Synthesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. | |||
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