Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0M5OC
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| Former ID |
DAP000583
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| Drug Name |
Trandolapril
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| Synonyms |
Gopten; Mavik; Odric; Odrik; Preran; Trandolaprilum; Udrik; Trandolaprilum [Latin]; RU 44570; RU44570; Mavik (TN); RU-44570; Trandolapril [INN:BAN]; Trandolapril (JAN/INN); (2S,3aR,7aS)-1-((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester; (2S,3aR,7aS)-1-(N-((1S)-1-((Ethyloxy)carbonyl)-3-phenylpropyl)-L-alanyl)octahydro-1H-indole-2-carboxylic Acid; (2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylicacid; 1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydro-1H-indol-2-carboxylic acid
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Approved | [1], [2] | |
| Therapeutic Class |
Antihypertensive Agents
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| Company |
Abbott Laboratories
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| Structure |
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Download2D MOL |
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| Formula |
C24H34N2O5
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| Canonical SMILES |
CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C3CCCCC3CC2C(=O)O
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| InChI |
1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1
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| InChIKey |
VXFJYXUZANRPDJ-WTNASJBWSA-N
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| CAS Number |
CAS 87679-37-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7847449, 7980822, 12013675, 14807551, 14929957, 17185447, 39472377, 46508300, 48416651, 49983793, 57364037, 78587898, 90340949, 93166962, 93619661, 103558689, 113992926, 118048541, 121361634, 124893803, 126662049, 131328953, 134223023, 134337874, 135060465, 135569875, 135723472, 136043950, 137002500, 139097173, 144205006, 144206703, 151982735, 152035469, 160848877, 160963864, 162176909, 163122933, 163564878, 164813794, 172919751, 175266111, 175612605, 178103069, 179116928, 184545941, 210279756, 210282079, 223702475, 224010570
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| ChEBI ID |
CHEBI:9649
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| ADReCS Drug ID | BADD_D02259 | |||
| SuperDrug ATC ID |
C09AA10
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| SuperDrug CAS ID |
cas=087679376
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides cellulosilyticus DSM 14838
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trandolapril can be metabolized by Bacteroides cellulosilyticus DSM 14838 (log2FC = -0.452; p = 0.037). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trandolapril can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.908; p = 0.037). | |||
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Studied Microbe: Bacteroides eggerthii DSM20697
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trandolapril can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -0.479; p = 0.041). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trandolapril can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -0.825; p = 0.028). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trandolapril can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.628; p = 0.019). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trandolapril can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -0.619; p = 0.03). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trandolapril can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -0.676; p = 0.006). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trandolapril can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.772; p = 0.025). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trandolapril can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -0.637; p = 0.041). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trandolapril can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -1.065; p = 0.016). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trandolapril can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -0.867; p = 0.012). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trandolapril can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -0.678; p = 0.02). | |||
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Studied Microbe: Odoribacter splanchnicus
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trandolapril can be metabolized by Odoribacter splanchnicus (log2FC = -0.559; p = 0.019). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trandolapril can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -0.66; p = 0.034). | |||
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Studied Microbe: Pretovella copri DSM 18205
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trandolapril can be metabolized by Pretovella copri DSM 18205 (log2FC = -0.503; p = 0.016). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Eubacterium biforme DSM 3989
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trandolapril can be metabolized by Eubacterium biforme DSM 3989 (log2FC = -0.502; p = 0.025). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiotensin-converting enzyme (ACE) | Target Info | Inhibitor | [4] |
| KEGG Pathway | Renin-angiotensin system | |||
| Chagas disease (American trypanosomiasis) | ||||
| Hypertrophic cardiomyopathy (HCM) | ||||
| Pathwhiz Pathway | Angiotensin Metabolism | |||
| Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
| WikiPathways | ACE Inhibitor Pathway | |||
| Metabolism of Angiotensinogen to Angiotensins | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6453). | |||
| REF 2 | New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | Selective reduction of central pulse pressure under angiotensin blockage in SHR: role of the fibronectin-alpha5beta1 integrin complex. Am J Hypertens. 2009 Jul;22(7):711-7. | |||
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