Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0N3PE
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| Former ID |
DAP000124
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| Drug Name |
Guanethidine
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| Synonyms |
Abapresin; Dopam; Dopom; Eutensol; Guanethidinum; Guanetidina; Ismelin; Isobarin; Octadin; Octadine; Octatensin; Octatensine; Oktadin; Oktatensin; Oktatenzin; Sanotensin; Guanethidine Sulphae; Guanethidine sulfate; Ismelin sulfate; Apo-Guanethidine; Guanethidine (INN); Guanethidine [INN:BAN]; Guanethidinum [INN-Latin]; Guanetidina [INN-Spanish]; Apo-Guanethidine (TN); Beta-1-Azacyclooctylethylguanidine; Guanethidine Sulfate (1:1); Guanethidine Sulfate (2:1); Su 5864 sulfate (1:1); N-(2-Perhydroazocin-1-ylethyl)guanidine; ((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine; (2-(Octahydro-1-azocinyl)ethyl)guanidine; 1-(2-azocan-1-ylethyl)guanidine; 1-[2-(azocan-1-yl)ethyl]guanidine; 2-(1'-Azacyclooctyl)ethylguanidine; 2-(1-N,N-Heptamethyleneimino)ethylguanidine; 2-[2-(azocan-1-yl)ethyl]guanidine
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| Drug Type |
Small molecular drug
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| Indication | Moderate and severe hypertension [ICD-11: BA00.Z; ICD-10: I10-I16] | Approved | [1] | |
| Therapeutic Class |
Antihypertensive Agents
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| Company |
Norvatis Phamaceuticals Corporation
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| Structure |
 |
Download2D MOL |
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| Formula |
C10H22N4
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| Canonical SMILES |
C1CCCN(CCC1)CCN=C(N)N
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| InChI |
1S/C10H22N4/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14/h1-9H2,(H4,11,12,13)
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| InChIKey |
ACGDKVXYNVEAGU-UHFFFAOYSA-N
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| CAS Number |
CAS 55-65-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9248, 794471, 7377191, 7979478, 11112157, 11335714, 11360953, 11363731, 11366293, 11368855, 11371412, 11374115, 11377017, 11461925, 11466345, 11467465, 11484942, 11486269, 11488919, 11490262, 11492383, 11494651, 15389628, 29222650, 46507567, 47216933, 47291281, 47291282, 47365372, 47885569, 48110617, 48185147, 48416075, 49698863, 49974728, 50100381, 50100382, 50669071, 56394979, 57321851, 85209451, 88826597, 91563079, 92098555, 96024723, 99445522, 103203421, 104303749, 118693183, 124954104
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| ChEBI ID |
CHEBI:5557
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| ADReCS Drug ID | BADD_D01045 | |||
| SuperDrug ATC ID |
C02CC02; S01EX01
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| SuperDrug CAS ID |
cas=000055652
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic neuron (AD neuro) | Target Info | Blocker | [2], [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Characterization of bradykinin-induced endothelium-independent contraction in equine basilar artery. J Vet Pharmacol Ther. 2009 Jun;32(3):264-70. | |||
| REF 3 | Proton acts as a neurotransmitter for nicotine-induced adrenergic and calcitonin gene-related peptide-containing nerve-mediated vasodilation in the... J Pharmacol Exp Ther. 2009 Sep;330(3):745-55. | |||
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