Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0R1BD
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| Former ID |
DNC001109
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| Drug Name |
Penicillin
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| Synonyms |
Cillin; Pentids; 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (Phenylmethyl)penicillin; 7005-30-3; NSC131815; (Phenylmethyl)penicillinic acid; 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; AC1L1DHC; AC1Q5UVJ; Penicilline G sodium salt; Oprea1_713794; Oprea1_861345; CHEMBL300052; SCHEMBL2109546; CTK2H5530
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Approved | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H18N2O4S
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| Canonical SMILES |
CC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)O)C
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| InChI |
1S/C16H18N2O4S/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)
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| InChIKey |
JGSARLDLIJGVTE-UHFFFAOYSA-N
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| CAS Number |
CAS 61-33-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
449427, 540220, 5424486, 8151575, 10319434, 11405098, 14924502, 29221517, 47291676, 48335077, 50070779, 57321271, 79379467, 92474870, 103141609, 104300333, 117546988, 125659680, 125817051, 125948246, 126430089, 126454088, 126671887, 126676861, 128272446, 137128564, 142058762, 162652735, 164826509, 169164760, 176331456, 196388009, 223655272, 228248447, 242084373, 251888715
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Escherichia
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[2] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Escherichia was not significantly changed by Penicillin. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Allobaculum
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces, cecal and ileal specimens | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Allobaculum was decreased by Penicillin. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Arthromitus
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces, cecal and ileal specimens | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Arthromitus was decreased by Penicillin. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Kitasatosporales | ||||
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Studied Microbe: Neisseria cocci
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Acute bronchitis | |||
| Description | The abundance of Neisseria cocci was increased by Penicillin. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Enterococcus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Enterococcus was decreased by Penicillin. | |||
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Studied Microbe: Lactobacillus
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces, cecal and ileal specimens | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Lactobacillus was decreased by Penicillin. | |||
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Studied Microbe: Viridans streptococci
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Acute bronchitis | |||
| Description | The abundance of Viridans streptococci was increased by Penicillin. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial Penicillin binding protein (Bact PBP) | Target Info | Modulator | [5] |
| References | Top | |||
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| REF 1 | ClinicalTrials.gov (NCT00363688) Treating Patients With a History of Non-Life Threatening Allergic Reaction to Penicillin With Penicillin. U.S. National Institutes of Health. | |||
| REF 2 | The influence of single dose intravenous antibiotics on faecal flora and emergence of Clostridium difficile. J Antimicrob Chemother. 1985 Mar;15(3):319-26. | |||
| REF 3 | Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences. Cell. 2014 Aug 14;158(4):705-721. | |||
| REF 4 | Comparative effects of cefadroxil and phenoxymethylpenicillin on the normal oropharyngeal and intestinal microflora. Infection. 1997 May-Jun;25(3):154-8. | |||
| REF 5 | Bacterial Resistance to Penicillin G by Decreased Affinity of Penicillin-Binding Proteins: A Mathematical Model | |||
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