Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0R5RR
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| Former ID |
DAP000849
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| Drug Name |
Clofarabine
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| Synonyms |
CAFdA; CFB; Clofarabina; Clofarabinum; Clofarex; Clolar; Evoltra; Clofarabine [USAN]; Clolar (TN); Evoltra (TN); Clofarabine (USAN/INN); Clolar, Evoltra, Clofarabine; Cl-F-Ara-A; (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol; 2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine; 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine; 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine; 2-Cl-2'-F-araA; 2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine; 3S211048
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| Drug Type |
Small molecular drug
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| Indication | Acute lymphoblastic leukaemia [ICD-11: 2A85; ICD-10: C85.1, C88.7] | Approved | [1], [2], [3], [4] | |
| Myelodysplastic syndrome [ICD-11: 2A37] | Approved | [1], [2], [3], [4] | ||
| Therapeutic Class |
Anticancer Agents
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| Structure |
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Download2D MOL |
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| Formula |
C10H11ClFN5O3
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| Canonical SMILES |
C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)CO)O)F)Cl)N
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| InChI |
1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1
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| InChIKey |
WDDPHFBMKLOVOX-AYQXTPAHSA-N
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| CAS Number |
CAS 123318-82-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
8149071, 10238376, 10317422, 12014412, 14800615, 14800616, 29300120, 46504968, 47205855, 50027432, 56459308, 57339361, 71821361, 77716344, 81092867, 92309003, 92719465, 93608050, 99437031, 99444025, 103707445, 104407717, 109610765, 118048878, 124757091, 125163895, 126584329, 126620778, 126652234, 126671067, 129564367, 134223319, 134338128, 135073562, 135698306, 136920392, 136946661, 136949087, 137005624, 141857409, 143493352, 144115841, 144205735, 152058774, 152237732, 152258941, 160647786, 160963976, 162011506, 162176704
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| ChEBI ID |
CHEBI:681569
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| ADReCS Drug ID | BADD_D00495 | |||
| SuperDrug ATC ID |
L01BB06
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial Penicillin binding protein (Bact PBP) | Target Info | Binder | [5] |
| Ribonucleotide reductase (RIR) | Target Info | Inhibitor | [5] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6802). | |||
| REF 2 | 2004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 4 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 5 | Clofarabine: past, present, and future. Leuk Lymphoma. 2007 Oct;48(10):1922-30. | |||
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