Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0S3PO
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| Former ID |
DIB011940
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| Drug Name |
Pelitinib
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| Synonyms |
EKB-569; EKI-569; WAY-EKB-569
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| Drug Type |
Small molecular drug
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| Indication | Lymphoma [ICD-11: 2A80-2A86; ICD-9: 202.8, 208.9] | Phase 2 | [1], [2] | |
| Company |
Wyeth
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H23ClFN5O2
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| Canonical SMILES |
CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)F)Cl)C#N)NC(=O)C=CCN(C)C
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| InChI |
1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+
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| InChIKey |
WVUNYSQLFKLYNI-AATRIKPKSA-N
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| CAS Number |
CAS 257933-82-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
11969814, 12015456, 14907361, 26676020, 43037753, 47207075, 48428303, 50100098, 52834556, 57369863, 85246192, 99007825, 99437128, 103730344, 109693543, 114573161, 118844936, 124757216, 125164020, 126666605, 131307623, 131480864, 134964337, 135135023, 135727422, 136367411, 136367831, 136367832, 137066020, 137249264, 139363244, 152186795, 152258783, 152344223, 160647634, 162011372, 162037581, 162202669, 164041946, 164827932, 172913625, 174528374, 177749438, 179294278, 180386844, 185978961, 198957925, 204362244, 223365979, 223374329
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| ChEBI ID |
CHEBI:38927
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7644). | |||
| REF 2 | ClinicalTrials.gov (NCT00067548) Study Evaluating EKB-569 in Advanced Non-Small Cell Lung Cancer. U.S. National Institutes of Health. | |||
| REF 3 | EGFR tyrosine kinase inhibitor pelitinib regulates radiation-induced p65-dependent telomerase activation in squamous cell carcinoma.Radiat Res.2013 Mar;179(3):304-12. | |||
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