Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0S6TK
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| Former ID |
DIB018041
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| Drug Name |
tamatinib
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| Synonyms |
R 406; R-406; R406 free base
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Clinical trial | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C22H23FN6O5
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| Canonical SMILES |
CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C
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| InChI |
1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
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| InChIKey |
NHHQJBCNYHBUSI-UHFFFAOYSA-N
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| CAS Number |
CAS 841290-80-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
16296087, 23397780, 42293201, 50077030, 57288231, 77344609, 99443630, 99460878, 103596121, 103904600, 103911497, 104103809, 104253192, 118049697, 121279875, 124772082, 126659679, 126726736, 135686088, 135686089, 135686106, 135686107, 135727442, 136367807, 136920409, 137275829, 141853025, 143498000, 152090530, 152234883, 152258324, 152344022, 160647163, 160968244, 162011591, 162202555, 162202679, 162920174, 164041983, 164824515, 170482429, 170483678, 170485720, 170496629, 170498439, 172912587, 174530755, 177748686, 178102333, 180190838
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| ChEBI ID |
CHEBI:91348
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Developmental toxicity associated with receptor tyrosine kinase Ret inhibition in reproductive toxicity testing. Birth Defects Res A Clin Mol Teratol. 2009 Feb;85(2):130-6. | |||
| REF 2 | Pharmacophore modeling study based on known spleen tyrosine kinase inhibitors together with virtual screening for identifying novel inhibitors. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1944-9. | |||
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