Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0V3ZA
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| Former ID |
DAP000078
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| Drug Name |
Dihydroergotamine
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| Synonyms |
Migranal (TN)
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| Drug Type |
Small molecular drug
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| Indication | Migraine [ICD-11: 8A80; ICD-10: G43, G43.9; ICD-9: 346] | Approved | [1] | |
| Therapeutic Class |
Antimigraine Agents
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| Company |
Pfizer Pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C33H37N5O5
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| Canonical SMILES |
CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C
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| InChI |
1S/C33H37N5O5/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32/h3-6,8-11,17,21,23,25-27,34,42H,7,12-16,18H2,1-2H3,(H,35,39)/t21-,23-,25-,26+,27+,32-,33+/m1/s1
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| InChIKey |
LUZRJRNZXALNLM-JGRZULCMSA-N
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| CAS Number |
CAS 511-12-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10000, 7979087, 8157604, 11335767, 11361006, 11363951, 11366513, 11369075, 11371529, 11374714, 11377237, 11461978, 11484971, 11489004, 11490211, 11492773, 11494871, 14788984, 14935810, 29229015, 46507711, 47291112, 47885391, 48110437, 48334472, 49963030, 49965612, 50153282, 57326281, 85789540, 90341683, 93166278, 96024534, 99313633, 103684622, 103905875, 104137088, 104171355, 104323551, 119501400, 124749650, 124883197, 124883198, 126688923, 127323995, 127323996, 127323997, 127323998, 127323999, 127324000
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| ChEBI ID |
CHEBI:4562
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| ADReCS Drug ID | BADD_D00671 ; BADD_D00672 | |||
| SuperDrug ATC ID |
N02CA01
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| SuperDrug CAS ID |
cas=000511126
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75. | |||
| REF 2 | Current and prospective pharmacological targets in relation to antimigraine action. Naunyn Schmiedebergs Arch Pharmacol. 2008 Oct;378(4):371-94. | |||
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