Drug Information
Drug General Information | Top | |||
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Drug ID |
D00FHI
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Former ID |
DIB002014
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Drug Name |
Zabiciprilat
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Synonyms |
Zabicipril; S-10211; S-9650
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Drug Type |
Small molecular drug
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Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Discontinued in Phase 2 | [1] | |
Company |
Servier
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Structure |
Download2D MOL |
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Formula |
C21H28N2O5
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Canonical SMILES |
CC(C(=O)N1C2CCC(C1C(=O)O)CC2)NC(CCC3=CC=CC=C3)C(=O)O
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InChI |
1S/C21H28N2O5/c1-13(22-17(20(25)26)12-7-14-5-3-2-4-6-14)19(24)23-16-10-8-15(9-11-16)18(23)21(27)28/h2-6,13,15-18,22H,7-12H2,1H3,(H,25,26)(H,27,28)/t13-,15?,16?,17-,18-/m0/s1
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InChIKey |
HBZJVGFXZTUXNI-XMQLQKOFSA-N
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CAS Number |
CAS 90103-92-7
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Angiotensin-converting enzyme (ACE) | Target Info | Inhibitor | [2] |
KEGG Pathway | Renin-angiotensin system | |||
Chagas disease (American trypanosomiasis) | ||||
Hypertrophic cardiomyopathy (HCM) | ||||
Pathwhiz Pathway | Angiotensin Metabolism | |||
Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
WikiPathways | ACE Inhibitor Pathway | |||
Metabolism of Angiotensinogen to Angiotensins |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000139) | |||
REF 2 | Enzyme immunoassays for a new angiotensin-converting enzyme inhibitor, zabicipril, and its active metabolite in human plasma: application to pharmacokinetic studies. Ther Drug Monit. 1993 Oct;15(5):448-54. |
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