Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00IPO
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| Former ID |
DNC005397
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| Drug Name |
2-(3-Isopropyl-phenyl)-propionic acid
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| Synonyms |
Benzeneacetic acid, alpha-methyl-3-(1-methylethyl)-; CHEMBL191103; SCHEMBL1345333; DHFSUPPYOBITGY-UHFFFAOYSA-N; 2-(3-isopropylphenyl)propanoic acid; AKOS022699991; 2-[(3'-isopropyl)phenyl]propionic acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C12H16O2
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| Canonical SMILES |
CC(C)C1=CC(=CC=C1)C(C)C(=O)O
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| InChI |
1S/C12H16O2/c1-8(2)10-5-4-6-11(7-10)9(3)12(13)14/h4-9H,1-3H3,(H,13,14)
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| InChIKey |
DHFSUPPYOBITGY-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | C-X-C chemokine receptor type 1 (CXCR1) | Target Info | Inhibitor | [1] |
| C-X-C chemokine receptor type 2 (CXCR2) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Chemokine signaling pathway | ||||
| Endocytosis | ||||
| Epithelial cell signaling in Helicobacter pylori infection | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| TNFalpha Signaling Pathway | ||||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
| Interleukin signaling pathway | ||||
| Pathway Interaction Database | IL8- and CXCR1-mediated signaling events | |||
| IL8- and CXCR2-mediated signaling events | ||||
| Reactome | Chemokine receptors bind chemokines | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Differentiation Pathway | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. | |||
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