Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00MYT
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| Former ID |
DAP000661
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| Drug Name |
Thiopental
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| Synonyms |
Intraval; Penthiobarbital; Pentothiobarbital; Thiomebumal; Thionembutal; Thiopentobarbital; Thiopentobarbitone; Thiopentone; Thiothal; Tiopentale; Trapanal; Thiopental [BAN]; Thiopental solution; Thiopentobarbituric acid; Tiopentale [Italian]; Sodium Pentothal (TN); Thiopental (TN); Thiopentone sodium (TN); Trapanal (TN); (+-)-Thiopental; (+/-)-THIOPENTAL; (+/-)-Thiopental solution; 2-Thio-5-ethyl-5-sec-pentylbarbituric acid; 4,6,(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-(9CI); 5-Ethyl-5-(1-methyl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione; 5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid; 5-ethyl-2-mercapto-5-(1-methylbutyl)pyrimidine-4,6(1H,5H)-dione; 5-ethyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione; 5-ethyl-5-pentan-2-yl-2-sulfanylidene-1,3-diazinane-4,6-dione
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| Drug Type |
Small molecular drug
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| Indication | Anaesthesia [ICD-11: 9A78.6; ICD-9: 338] | Approved | [1], [2] | |
| Therapeutic Class |
Hypnotics and Sedatives
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| Company |
Abbott Laboratories
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| Structure |
 |
Download2D MOL |
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| Formula |
C11H18N2O2S
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| Canonical SMILES |
CCCC(C)C1(C(=O)NC(=S)NC1=O)CC
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| InChI |
1S/C11H18N2O2S/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)
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| InChIKey |
IUJDSEJGGMCXSG-UHFFFAOYSA-N
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| CAS Number |
CAS 76-75-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9724, 607917, 4785343, 6467449, 7980775, 10036288, 10535341, 11336168, 11361407, 11364686, 11367248, 11369810, 11372900, 11374149, 11377973, 11462379, 11485951, 11489814, 11491596, 11492390, 11495600, 14847511, 24899925, 24899928, 29215503, 34666697, 46504621, 47662379, 48259334, 48259335, 48416612, 49874351, 50521000, 57410125, 57654650, 81065587, 85307774, 85787415, 92714660, 103165674, 103954037, 104226110, 111610413, 117425383, 126623959, 126670641, 128221740, 134337950, 134971833, 135651257
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| ChEBI ID |
CHEBI:102166
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| SuperDrug ATC ID |
N01AF03; N05CA19
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| SuperDrug CAS ID |
cas=000076755
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Fatty acid amide hydrolase (FAAH) | Target Info | Inhibitor | [3] |
| BioCyc | Anandamide degradation | |||
| KEGG Pathway | Retrograde endocannabinoid signaling | |||
| Panther Pathway | Anandamide degradation | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2579). | |||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 011679. | |||
| REF 3 | The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. Br J Pharmacol. 2003 Jul;139(5):1005-13. | |||
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