Target Information

Target General Information

Top

Target ID

T11754 (Former ID: TTDS00177)

Target Name

Fatty acid amide hydrolase (FAAH)

Synonyms

Oleamidehydrolase; Anandamide amidohydrolase

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Gene Name

NO-GeName

Target Type

Successful target

[1]

Disease

[+] 1 Target-related Diseases

Corneal disease [ICD-11: 9A76-9A78]

Function

Degradesbioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.

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UniProt ID

NOUNIPROTAC

Drugs and Modes of Action

Top

Approved Drug(s)

[+] 2 Approved Drugs

Propofol

Drug Info

Approved

Anaesthesia

[2], [3]

Thiopental

Drug Info

Approved

Anaesthesia

[4], [5]

Clinical Trial Drug(s)

[+] 5 Clinical Trial Drugs

IW-6118

Drug Info

Phase 2

Inflammation

[6]

JNJ-42165279

Drug Info

Phase 2

Anxiety disorder

[7]

PF-04457845

Drug Info

Phase 2

Liver disease

[8]

SSR411298

Drug Info

Phase 2

Major depressive disorder

[9]

IPI-940

Drug Info

Phase 1

Pain

[10]

Mode of Action

[+] 2 Modes of Action

Inhibitor

[+] 298 Inhibitor drugs

Propofol

Drug Info

[1], [11]

Thiopental

Drug Info

[1]

JNJ-42165279

Drug Info

[13]

PF-04457845

Drug Info

[14]

SSR411298

Drug Info

[15]

IPI-940

Drug Info

[16]

Aryl urea derivative 1

Drug Info

[17]

Aryl urea derivative 2

Drug Info

[17]

Aryl urea derivative 3

Drug Info

[17]

Aryl urea derivative 4

Drug Info

[17]

Aryl urea derivative 5

Drug Info

[17]

Azetidine urea derivative 1

Drug Info

[17]

Azetidine urea derivative 2

Drug Info

[17]

Azetidine urea derivative 3

Drug Info

[17]

Azole derivative 1

Drug Info

[17]

Azole derivative 2

Drug Info

[17]

Azole derivative 3

Drug Info

[17]

Azole derivative 4

Drug Info

[17]

Azole derivative 5

Drug Info

[17]

Benzoxazole derivative 1

Drug Info

[17]

Benzyl pyrrolyloxoacetamide derivative 1

Drug Info

[17]

Benzyl pyrrolyloxoacetamide derivative 2

Drug Info

[17]

Boronic acid derivative 1

Drug Info

[17]

Boronic acid derivative 2

Drug Info

[17]

Boronic acid derivative 3

Drug Info

[17]

Boronic acid derivative 4

Drug Info

[17]

Boronic acid derivative 5

Drug Info

[17]

Boronic acid derivative 6

Drug Info

[17]

Carbamate derivative 1

Drug Info

[17]

Carbamate derivative 10

Drug Info

[18]

Carbamate derivative 16

Drug Info

[18]

Carbamate derivative 17

Drug Info

[18]

Carbamate derivative 3

Drug Info

[17]

Carbamate derivative 7

Drug Info

[17]

Carbamate derivative 8

Drug Info

[17]

Carbamate derivative 9

Drug Info

[18]

Carbamide derivative 1

Drug Info

[17]

Carbamide derivative 24

Drug Info

[18]

Carbamide derivative 25

Drug Info

[18]

Carbamide derivative 26

Drug Info

[18]

Enol carbamate derivative 1

Drug Info

[17]

Ethylaminopyrimidine derivative 1

Drug Info

[17]

Heteroaryl-substituted urea derivative 1

Drug Info

[17]

Heteroaryl-substituted urea derivative 2

Drug Info

[17]

Imidazolyl urea derivative 1

Drug Info

[17]

Isoxazoline derivative 1

Drug Info

[17]

Isoxazoline derivative 2

Drug Info

[17]

Isoxazoline derivative 3

Drug Info

[17]

Isoxazoline derivative 4

Drug Info

[17]

Ketoheterocycle derivative 1

Drug Info

[17]

Ketoheterocycle derivative 2

Drug Info

[17]

Ketoheterocycle derivative 3

Drug Info

[17]

Ketoheterocycle derivative 4

Drug Info

[17]

N-alkyl-4-oxazolecar boxamide derivative 1

Drug Info

[17]

N-alkyl-4-oxazolecar boxamide derivative 2

Drug Info

[17]

Piperazine carbamic compound 1

Drug Info

[18]

Piperazine carbamic compound 2

Drug Info

[18]

Piperazine urea derivative 1

Drug Info

[17]

PMID26413912-Compound-84

Drug Info

[17]

PMID29053063-Compound-11d

Drug Info

[18]

PMID29053063-Compound-14

Drug Info

[18]

PMID29053063-Compound-15

Drug Info

[18]

Pyrazole derivative 80

Drug Info

[18]

Pyrazole derivative 81

Drug Info

[18]

Pyrazole derivative 82

Drug Info

[18]

Pyrazole derivative 83

Drug Info

[18]

Pyrazole derivative 84

Drug Info

[18]

Pyrimidinyl ethylenediamine derivative 1

Drug Info

[17]

Pyrrolidinyl urea derivative 1

Drug Info

[17]

Spirocyclic diamine urea derivative 1

Drug Info

[17]

Spirocyclic diamine urea derivative 2

Drug Info

[17]

Tetra-hydro-naphthalene derivative 1

Drug Info

[17]

Tetra-hydro-naphthalene derivative 2

Drug Info

[17]

Tetra-hydro-naphthalene derivative 3

Drug Info

[17]

Tetra-hydro-naphthyridine derivative 1

Drug Info

[17]

Tetra-substituted urea derivative 1

Drug Info

[17]

Tetra-substituted urea derivative 2

Drug Info

[17]

Tetrazolyl urea derivative 1

Drug Info

[17]

(+/-)-3-(but-3-enyl)-1-pent-4-enoylazetidin-2-one

Drug Info

[19]

(+/-)-3-(pent-4-enyl)azetidin-2-one

Drug Info

[19]

(+/-)-3-allyl-1-pent-4-enoylazetidin-2-one

Drug Info

[19]

(+/-)-3-allylazetidin-2-one

Drug Info

[19]

(+/-)-oxiran-2-ylmethyl (9Z)-hexadec-9-enoate

Drug Info

[20]

(+/-)-oxiran-2-ylmethyl (9Z)-octadec-9-enoate

Drug Info

[20]

(Z)-1,1,1-Trifluoro-nonadec-10-en-2-one

Drug Info

[21]

(Z)-1-(4-phenyloxazol-2-yl)octadec-9-en-1-one

Drug Info

[22]

(Z)-1-(benzo[d]oxazol-2-yl)octadec-9-en-1-one

Drug Info

[22]

(Z)-1-(pyridazin-3-yl)octadec-9-en-1-one

Drug Info

[22]

(Z)-2,2-Dimethyl-1-oxazol-2-yl-octadec-9-en-1-one

Drug Info

[23]

(Z)-2-Methyl-1-oxazol-2-yl-octadec-9-en-1-one

Drug Info

[23]

1,1,1-trifluoro-3-(hexylthio)propan-2-one

Drug Info

[24]

1,1,1-trifluoro-3-(octylsulfinyl)propan-2-one

Drug Info

[24]

1,1,1-trifluoro-3-(octylsulfonyl)propan-2-one

Drug Info

[24]

1,1,1-trifluoro-3-(octylthio)propan-2-one

Drug Info

[24]

1,1,1-Trifluoro-7-phenylheptan-2-one

Drug Info

[21]

1,1,1-Trifluoro-8-phenyl-octan-2-one

Drug Info

[21]

1,1,1-Trifluoro-9-phenyl-nonan-2-one

Drug Info

[21]

1,1,1-Trifluoro-nonadecan-2-one

Drug Info

[21]

1,1,1-Trifluoro-tridecan-2-one

Drug Info

[21]

100

1,1,1-Trifluoro-undecan-2-one

Drug Info

[21]

101

1,1,1-trifluorododecan-2-one

Drug Info

[24]

102

1,10-(methylenedi-4,1-phenylene)bismaleimide

Drug Info

[25]

103

1,4-bis(malimido)xylene

Drug Info

[25]

104

1,8-bis-maleimidodiethyleneglycol

Drug Info

[25]

105

1-(1,2,4-Oxadiazol-3-yl)-7-phenylheptan-1-one

Drug Info

[26]

106

1-(1,2,4-Oxadiazol-5-yl)-7-phenylheptan-1-one

Drug Info

[26]

107

1-(1,3,4-Oxadiazol-2-yl)-7-phenylheptan-1-one

Drug Info

[26]

108

1-(1,3,4-oxadiazol-2-yl)octadec-9-en-1-one

Drug Info

[26]

109

1-(1,3,4-thiadiazol-2-yl)octadec-9-en-1-one

Drug Info

[26]

110

1-(4-acetyloxazol-2-yl)-7-phenylheptan-1-one

Drug Info

[27]

111

1-(4-bromooxazol-2-yl)-7-phenylheptan-1-one

Drug Info

[27]

112

1-(4-chlorooxazol-2-yl)-7-phenylheptan-1-one

Drug Info

[27]

113

1-(4-iodooxazol-2-yl)-7-phenylheptan-1-one

Drug Info

[27]

114

1-(4-methoxyoxazol-2-yl)-7-phenylheptan-1-one

Drug Info

[27]

115

1-(4-methyloxazol-2-yl)-7-phenylheptan-1-one

Drug Info

[27]

116

1-(5-(furan-2-yl)oxazol-2-yl)octadec-9-en-1-one

Drug Info

[26]

117

1-(5-(pyridin-2-yl)oxazol-2-yl)dodecan-1-one

Drug Info

[22]

118

1-(5-(pyridin-2-yl)oxazol-2-yl)octadec-9-en-1-one

Drug Info

[26]

119

1-(5-(pyridin-2-yl)oxazol-2-yl)octan-1-one

Drug Info

[22]

120

1-(5-(pyridin-2-yl)oxazol-2-yl)pentan-1-one

Drug Info

[22]

121

1-(5-fluorooxazol-2-yl)-7-phenylheptan-1-one

Drug Info

[22]

122

1-(5-methyloxazol-2-yl)-7-phenylheptan-1-one

Drug Info

[22]

123

1-(5-phenyloxazol-2-yl)octadec-9-en-1-one

Drug Info

[26]

124

1-(5-Pyridin-2-yl-oxazol-2-yl)-octadec-9-yn-1-one

Drug Info

[21]

125

1-(oxazol-2-yl)-3-(4-phenoxyphenyl)propan-1-one

Drug Info

[28]

126

1-(oxazol-2-yl)-4-(piperidin-4-yl)butan-1-one

Drug Info

[29]

127

1-(oxazol-2-yl)-7-phenylheptan-1-one

Drug Info

[27]

128

1-(oxazol-2-yl)octadec-9-en-1-one

Drug Info

[26]

129

1-(oxazolo[4,5-b]pyridin-2-yl)dodecan-1-one

Drug Info

[22]

130

1-(oxazolo[4,5-b]pyridin-2-yl)octan-1-one

Drug Info

[22]

131

1-(oxazolo[4,5-b]pyridin-2-yl)pentan-1-one

Drug Info

[22]

132

1-Benzooxazol-2-yl-6-phenyl-hexan-1-one

Drug Info

[21]

133

1-Biphenyl-4-ylmaleimide

Drug Info

[25]

134

1-Biphenyl-4-ylmethylmaleimide

Drug Info

[25]

135

1-DODECANOL

Drug Info

[30]

136

1-Imidazol-1-yl-3-(4-octylphenoxy)propan-2-one

Drug Info

[31]

137

1-Oxazolo[4,5-b]pyridin-2-yl-6-phenyl-hexan-1-one

Drug Info

[32]

138

1-Oxazolo[4,5-b]pyridin-2-yl-octadec-9-yn-1-one

Drug Info

[21]

139

2,2-dimethyl-3-methyleneheptadecane

Drug Info

[24]

140

2,4-difluorophenyl 4-butoxybenzylcarbamate

Drug Info

[33]

141

2-(7-phenylheptanoyl)oxazole-4-carbaldehyde

Drug Info

[27]

142

2-(7-phenylheptanoyl)oxazole-4-carbonitrile

Drug Info

[27]

143

2-(7-phenylheptanoyl)oxazole-4-carboxamide

Drug Info

[27]

144

2-(7-phenylheptanoyl)oxazole-4-carboxylic acid

Drug Info

[27]

145

2-(7-phenylheptanoyl)oxazole-5-carbonitrile

Drug Info

[27]

146

2-(7-phenylheptanoyl)oxazole-5-carboxylic acid

Drug Info

[27]

147

2-(biphenyl-4-yl)vinylboronic acid

Drug Info

[34]

148

2-arachidonoylglycerol

Drug Info

[35]

149

2-chloro-1-(5-(pyridin-2-yl)oxazol-2-yl)ethanone

Drug Info

[36]

150

2-Cyclohexylacetic acidbiphenyl-3-yl ester

Drug Info

[37]

151

2-fluorophenyl 1-(4-butoxyphenyl)propylcarbamate

Drug Info

[33]

152

2-fluorophenyl 4'-ethylbiphenyl-4-ylcarbamate

Drug Info

[33]

153

2-fluorophenyl 4-(decyloxy)phenylcarbamate

Drug Info

[33]

154

2-fluorophenyl 4-(dodecyloxy)phenylcarbamate

Drug Info

[33]

155

2-fluorophenyl 4-(heptyloxy)phenylcarbamate

Drug Info

[33]

156

2-fluorophenyl 4-(hexyloxy)phenylcarbamate

Drug Info

[33]

157

2-fluorophenyl 4-(octyloxy)phenylcarbamate

Drug Info

[33]

158

2-fluorophenyl 4-(undecyloxy)phenylcarbamate

Drug Info

[33]

159

2-fluorophenyl 4-butoxybenzylcarbamate

Drug Info

[33]

160

2-fluorophenyl 4-butoxyphenylcarbamate

Drug Info

[33]

161

2-fluorophenyl 4-phenoxyphenylcarbamate

Drug Info

[33]

162

2-fluorophenylboronic acid

Drug Info

[34]

163

2-methoxyphenylboronic acid

Drug Info

[34]

164

3'-carbamoylbiphenyl-3-yl 6-phenylhexylcarbamate

Drug Info

[38]

165

3,3-di(pent-4-enyl)azetidin-2-one

Drug Info

[19]

166

3-(4,5-Dihydrooxazol-2-yl)phenyl propylcarbamate

Drug Info

[39]

167

3-(benzo[d]oxazol-2-yl)phenyl propylcarbamate

Drug Info

[39]

168

3-(biphenyl-4-yl)-1-(oxazol-2-yl)propan-1-one

Drug Info

[28]

169

3-(decylsulfinyl)-1,1,1-trifluoropropan-2-one

Drug Info

[24]

170

3-(decylsulfonyl)-1,1,1-trifluoropropan-2-one

Drug Info

[24]

171

3-(decylthio)-1,1,1-trifluoropropan-2-one

Drug Info

[24]

172

3-(dodecylsulfinyl)-1,1,1-trifluoropropan-2-one

Drug Info

[24]

173

3-(dodecylsulfonyl)-1,1,1-trifluoropropan-2-one

Drug Info

[24]

174

3-(ethoxycarbonyl)phenylboronic acid

Drug Info

[34]

175

3-(trifluoromethyl)phenyl 4-butoxybenzylcarbamate

Drug Info

[33]

176

3-(trifluoromethyl)phenylboronic acid

Drug Info

[34]

177

3-chlorophenyl 4-butoxybenzylcarbamate

Drug Info

[33]

178

3-cyanophenylboronic acid

Drug Info

[34]

179

3-methoxyphenylboronic acid

Drug Info

[34]

180

4-(1,2,3-thiadiazol-4-yl)phenyl butylcarbamate

Drug Info

[40]

181

4-(1,2,3-thiadiazol-4-yl)phenyl hexylcarbamate

Drug Info

[40]

182

4-(4,5-dihydrothiazol-2-yl)phenyl butylcarbamate

Drug Info

[40]

183

4-(cyclohexylmethylcarbamoyloxy)benzoic acid

Drug Info

[38]

184

4-(thiazol-2-yl)phenyl butylcarbamate

Drug Info

[41]

185

4-(trifluoromethyl)phenylboronic acid

Drug Info

[34]

186

4-cyanophenyl ethyl dodecylphosphonate

Drug Info

[42]

187

4-cyanophenylboronic acid

Drug Info

[34]

188

4-fluorophenyl 1-(4-butoxyphenyl)propylcarbamate

Drug Info

[33]

189

4-fluorophenyl 4-butoxybenzylcarbamate

Drug Info

[33]

190

4-fluorophenylboronic acid

Drug Info

[34]

191

4-methoxyphenyl 1-(4-butoxyphenyl)propylcarbamate

Drug Info

[33]

192

4-methoxyphenylboronic acid

Drug Info

[34]

193

4-Nitrophenyl 4-Benzylpiperazine-1-carboxylate

Drug Info

[43]

194

4-nitrophenylboronic acid

Drug Info

[34]

195

4-nonylphenylboronic acid

Drug Info

[34]

196

4-Phenylbutylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[37]

197

6-fluoropyridin-3-ylboronic acid

Drug Info

[34]

198

6-Phenylhexylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[37]

199

7-Phenyl-1-(1,3,4-thiadiazol-2-yl)-heptan-1-one

Drug Info

[26]

200

7-Phenyl-1-(2H-tetrazol-5-yl)-heptan-1-one

Drug Info

[26]

201

7-phenyl-1-(4-phenyloxazol-2-yl)heptan-1-one

Drug Info

[27]

202

7-phenyl-1-(5-phenyloxazol-2-yl)heptan-1-one

Drug Info

[26]

203

7-Phenyl-1-(pyridazin-3-yl)-heptan-1-one

Drug Info

[26]

204

7-Phenyl-1-(thiazol-2-yl)-heptan-1-one

Drug Info

[26]

205

8-Phenyloctylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[37]

206

Adamant-1-ylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[37]

207

Allylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[37]

208

AM-404

Drug Info

[44]

209

AR-C70484XX

Drug Info

[31]

210

ARACHIDONYL TRIFLUOROMETHYLKETONE

Drug Info

[31]

211

Benzaldehyde O-4-(decyloxy)phenylcarbamoyl oxime

Drug Info

[33]

212

Benzaldehyde O-4-(heptyloxy)phenylcarbamoyl oxime

Drug Info

[33]

213

Benzaldehyde O-4-(hexyloxy)phenylcarbamoyl oxime

Drug Info

[33]

214

Benzaldehyde O-4-(nonyloxy)phenylcarbamoyl oxime

Drug Info

[33]

215

Benzaldehyde O-4-(octyloxy)phenylcarbamoyl oxime

Drug Info

[33]

216

Benzaldehyde O-4-(pentyloxy)phenylcarbamoyl oxime

Drug Info

[33]

217

Benzaldehyde O-4-butoxyphenylcarbamoyl oxime

Drug Info

[33]

218

Benzaldehyde O-4-ethoxyphenylcarbamoyl oxime

Drug Info

[33]

219

Benzaldehyde O-4-methoxyphenylcarbamoyl oxime

Drug Info

[33]

220

Benzaldehyde O-4-propoxyphenylcarbamoyl oxime

Drug Info

[33]

221

Benzofuran-2-ylboronic acid

Drug Info

[34]

222

Benzo[b]thiophen-2-ylboronic acid

Drug Info

[34]

223

Benzylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[37]

224

Biphenyl-3-ylboronic acid

Drug Info

[34]

225

Biphenyl-3-ylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[37]

226

Biphenyl-3-ylcarbamic acid cyclohexyl ester

Drug Info

[25]

227

Biphenyl-4-ylboronic acid

Drug Info

[34]

228

BMS-1

Drug Info

[45]

229

bromoenol lactone

Drug Info

[38]

230

Chlorphrifos oxon

Drug Info

[46]

231

Cyclobutylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[37]

232

Cyclohexyl biphenyl-4-ylcarbamate

Drug Info

[40]

233

Cyclohexylcarbamic acidbiphenyl-3-yl ester

Drug Info

[37]

234

Cyclohexylmethylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[37]

235

Cyclopentyl(5-(pyridin-2-yl)oxazol-2-yl)methanone

Drug Info

[36]

236

Cyclopentylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[37]

237

Dodecane-1-sulfonyl fluoride

Drug Info

[42]

238

Ethyl octylfluorophosphonate

Drug Info

[46]

239

Furan-2-ylmethylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[37]

240

HTS-00798

Drug Info

[41]

241

Indan-2-ylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[37]

242

Isopropyl 4-nitrophenyl dodecylphosphonate

Drug Info

[42]

243

Isopropyl dodecylfluorophosphonate

Drug Info

[46]

244

Isopropylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[37]

245

JNJ-1661010

Drug Info

[47]

246

LY-2183240

Drug Info

[38]

247

LY-2318912

Drug Info

[48]

248

Methoxy arachidonyl fluorophosphonate

Drug Info

[49]

249

Methyl 2-(7-phenylheptanoyl)oxazole-4-carboxylate

Drug Info

[27]

250

Methyl 2-(7-phenylheptanoyl)oxazole-5-carboxylate

Drug Info

[26]

251

Methyl icosylphosphonofluoridate

Drug Info

[42]

252

Methylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[37]

253

N-(2-hydroxyethyl)linoleoylamide

Drug Info

[50]

254

N-(2-iodethyl)arachidonylamide

Drug Info

[50]

255

N-(2-iodoethyl)linoleoylamide

Drug Info

[50]

256

N-(4-hydroxybenzyl)icosa-5,8,11,14-tetraenamide

Drug Info

[44]

257

N-arachidonylmaleimide

Drug Info

[25]

258

N-Butylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[37]

259

N-Hexylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[37]

260

N-Octylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[37]

261

Naphthalen-2-yl cyclohexylcarbamate

Drug Info

[38]

262

NICARBAZIN

Drug Info

[51]

263

Nicotinaldehyde O-4-butoxyphenylcarbamoyl oxime

Drug Info

[33]

264

Nicotinaldehyde O-4-ethoxyphenylcarbamoyl oxime

Drug Info

[33]

265

Nicotinaldehyde O-4-propoxyphenylcarbamoyl oxime

Drug Info

[33]

266

Octane-1-sulfonyl fluoride

Drug Info

[42]

267

OL-135

Drug Info

[52]

268

OL-92

Drug Info

[45]

269

Org-231295

Drug Info

[16], [31]

270

PARAOXON

Drug Info

[46]

271

PF3845

Drug Info

[53]

272

PF750

Drug Info

[54]

273

Phenethylboronic acid

Drug Info

[34]

274

Phenethylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[37]

275

PHENMEDIPHAM

Drug Info

[51]

276

Phenyl 1-(4-butoxyphenyl)propylcarbamate

Drug Info

[33]

277

Phenyl 4-(decyloxy)phenylcarbamate

Drug Info

[33]

278

Phenyl 4-(dodecyloxy)phenylcarbamate

Drug Info

[33]

279

Phenyl 4-(heptyloxy)phenylcarbamate

Drug Info

[33]

280

Phenyl 4-(hexyloxy)phenylcarbamate

Drug Info

[33]

281

Phenyl 4-(octyloxy)phenylcarbamate

Drug Info

[33]

282

Phenyl 4-(undecyloxy)phenylcarbamate

Drug Info

[33]

283

Phenyl Boronic acid

Drug Info

[34]

284

Phenyl-1,4-bismaleimide

Drug Info

[25]

285

Phenylcarbamic Acid Biphenyl-3-yl Ester

Drug Info

[37]

286

Propan-2-one O-3-butoxyphenylcarbamoyl oxime

Drug Info

[33]

287

Propan-2-one O-4-(decyloxy)phenylcarbamoyl oxime

Drug Info

[33]

288

Propan-2-one O-4-(heptyloxy)phenylcarbamoyl oxime

Drug Info

[33]

289

Propan-2-one O-4-(hexyloxy)phenylcarbamoyl oxime

Drug Info

[33]

290

Propan-2-one O-4-(nonyloxy)phenylcarbamoyl oxime

Drug Info

[33]

291

Propan-2-one O-4-(octyloxy)phenylcarbamoyl oxime

Drug Info

[33]

292

Propan-2-one O-4-(pentyloxy)phenylcarbamoyl oxime

Drug Info

[33]

293

Propan-2-one O-4-butoxybenzylcarbamoyl oxime

Drug Info

[33]

294

Propan-2-one O-4-butoxyphenylcarbamoyl oxime

Drug Info

[33]

295

Propan-2-one O-4-ethoxyphenylcarbamoyl oxime

Drug Info

[33]

296

Propan-2-one O-4-propoxyphenylcarbamoyl oxime

Drug Info

[33]

297

Pyridin-3-yl 4-butoxybenzylcarbamate

Drug Info

[33]

298

VER-156084

Drug Info

[55]

Modulator

[+] 1 Modulator drugs

IW-6118

Drug Info

[12]

Drug Property Profile of Target

Top

(1) Molecular Weight (mw) based Drug Clustering

(2) Octanol/Water Partition Coefficient (xlogp) based Drug Clustering

(3) Hydrogen Bond Donor Count (hbonddonor) based Drug Clustering

(4) Hydrogen Bond Acceptor Count (hbondacc) based Drug Clustering

(5) Rotatable Bond Count (rotbonds) based Drug Clustering

(6) Topological Polar Surface Area (polararea) based Drug Clustering

"RO5" indicates the cutoff set by lipinski's rule of five; "D123AB" colored in GREEN denotes the no violation of any cutoff in lipinski's rule of five; "D123AB" colored in PURPLE refers to the violation of only one cutoff in lipinski's rule of five; "D123AB" colored in BLACK represents the violation of more than one cutoffs in lipinski's rule of five

Co-Targets

Top

Co-Targets

Co-Targets Info

Target Profiles in Patients

Top

Target Expression
Profile (TEP)

Target Expression Profile Info

Target Affiliated Biological Pathways

Top

BioCyc

[+] 1 BioCyc Pathways

Anandamide degradation

KEGG Pathway

[+] 1 KEGG Pathways

Retrograde endocannabinoid signaling

Panther Pathway

[+] 1 Panther Pathways

Anandamide degradation

Target-Related Models and Studies

Top

Target Validation

Target Validation Info

References

Top

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1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amide hydrolase. Bioorg Med Chem. 2010 Jan 15;18(2):945-52.

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Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7.

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Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60.

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Conformationally constrained analogues of 2-arachidonoylglycerol. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5959-63.

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REF 45

Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors. J Med Chem. 2009 Jan 8;52(1):170-80.

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REF 54

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