Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09YUL
|
|||
| Former ID |
DIB019025
|
|||
| Drug Name |
bromoenol lactone
|
|||
| Synonyms |
Bromoenol lactone; HELSS; 88070-98-8; 6-Btnpo; BTNP; C16H13BrO2; CHEMBL6206; BEL; 6-(Bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one; Haloenol lactone suicide substrate; BYUCSFWXCMTYOI-ZRDIBKRKSA-N; (E)-6-(Bromomethylene)tetrahydro-3-(1-naphthalenyl)-2H-Pyran-2-one; (E)-6-(Bromomethylene)-3-(1-naphthalenyl)tetrahydro-2H-pyran-2-one; bromoenolactone; E-6-(Bromoethylene)tetrahydro-3-(1-naphthyl)-2H-pyran-2-one; 2H-Pyran-2-one, 6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-, (E)-; SR-01000075707; bromoenolactone
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C16H13BrO2
|
|||
| Canonical SMILES |
C1CC(=CBr)OC(=O)C1C2=CC=CC3=CC=CC=C32
|
|||
| InChI |
1S/C16H13BrO2/c17-10-12-8-9-15(16(18)19-12)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,10,15H,8-9H2/b12-10+
|
|||
| InChIKey |
BYUCSFWXCMTYOI-ZRDIBKRKSA-N
|
|||
| CAS Number |
CAS 88070-98-8
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
11849186, 14923672, 17404713, 24278257, 26758868, 40488569, 48185096, 50065353, 50105889, 50105890, 52728859, 53777256, 53788731, 57365301, 85230933, 90340650, 92303723, 103163692, 103977090, 114278738, 124749491, 124879382, 126602170, 134351055, 135072392, 136345244, 137393668, 141423598, 162228679, 163564104, 163687976, 178101841, 179326498, 184590058, 228208133, 228208199, 241152016, 249810664, 250136843, 252457510, 252466907
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Fatty acid amide hydrolase (FAAH) | Target Info | Inhibitor | [2] |
| Short transient receptor potential channel 5 (TRPC5) | Target Info | Blocker (channel blocker) | [3] | |
| BioCyc | Anandamide degradation | |||
| KEGG Pathway | Retrograde endocannabinoid signaling | |||
| Panther Pathway | Alzheimer disease-presenilin pathway | |||
| Anandamide degradation | ||||
| Reactome | TRP channels | |||
| Role of second messengers in netrin-1 signaling | ||||
| WikiPathways | Netrin-1 signaling | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5149). | |||
| REF 2 | Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors. J Med Chem. 2008 Dec 11;51(23):7327-43. | |||
| REF 3 | Bromoenol lactone inhibits voltage-gated Ca2+ and transient receptor potential canonical channels. J Pharmacol Exp Ther. 2011 Nov;339(2):329-40. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.