Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09GVB
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| Former ID |
DNC004661
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| Drug Name |
OL-135
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| Synonyms |
OL-135; 681135-77-3; CHEMBL177577; 7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one; ILOIOIGZFHGSMS-UHFFFAOYSA-N; SCHEMBL1471932; GTPL5235; BDBM23120; ORL 135; OL135; ZINC3949004; KB-79672; 7-phenyl-1-(5-(pyridin-2-yl)oxazol-2-yl)heptan-1-one
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| Drug Type |
Small molecular drug
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| Indication | Pain [ICD-11: MG30-MG3Z] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C21H22N2O2
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| Canonical SMILES |
C1=CC=C(C=C1)CCCCCCC(=O)C2=NC=C(O2)C3=CC=CC=N3
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| InChI |
1S/C21H22N2O2/c24-19(14-7-2-1-4-10-17-11-5-3-6-12-17)21-23-16-20(25-21)18-13-8-9-15-22-18/h3,5-6,8-9,11-13,15-16H,1-2,4,7,10,14H2
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| InChIKey |
ILOIOIGZFHGSMS-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Fatty acid amide hydrolase (FAAH) | Target Info | Inhibitor | [2] |
| BioCyc | Anandamide degradation | |||
| KEGG Pathway | Retrograde endocannabinoid signaling | |||
| Panther Pathway | Anandamide degradation | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5235). | |||
| REF 2 | X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase. J Med Chem. 2010 Jan 14;53(1):230-40. | |||
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