Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0W5WG
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| Former ID |
DNC008660
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| Drug Name |
JNJ-1661010
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| Synonyms |
681136-29-8; JNJ-1661010; JNJ 1661010; JNJ1661010; N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide; UNII-62521S57AU; 1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-; N-PHENYL-4-(3-PHENYL-1,2,4-THIADIAZOL-5-YL)-1-PIPERAZINECARBOXAMIDE; CHEMBL460273; 62521S57AU; BHBOSTKQCZEAJM-UHFFFAOYSA-N; ACMC-20emff; AC1MDCTI; AC1Q5LMB; Oprea1_746619; MLS001111246; SCHEMBL1164398; GTPL5206; CTK1J2536; cid_2809273; DTXSID00384599; MolPort-001-806-365; HMS3651L15; HMS1662H10; HMS2801K13; BCP06935; EX-A2218
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C19H19N5OS
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| Canonical SMILES |
C1CN(CCN1C2=NC(=NS2)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4
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| InChI |
1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
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| InChIKey |
BHBOSTKQCZEAJM-UHFFFAOYSA-N
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| CAS Number |
CAS 681136-29-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3267393, 5376539, 8334260, 12057226, 24259607, 26729443, 40177582, 48061254, 51525486, 88849348, 92262667, 103012314, 103586821, 104100667, 111423125, 117572635, 125145653, 125515447, 134345865, 135698019, 137604757, 139510995, 152159641, 162160284, 162248699, 162312792, 162569742, 164194100, 172113648, 178101892, 179332136, 198939445, 204370507, 223400411, 223490032, 224229613, 227401620, 241376345, 246708308, 252125965, 252157139, 252262425, 252438618, 252472163
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Fatty acid amide hydrolase (FAAH) | Target Info | Inhibitor | [2] |
| BioCyc | Anandamide degradation | |||
| KEGG Pathway | Retrograde endocannabinoid signaling | |||
| Panther Pathway | Anandamide degradation | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5206). | |||
| REF 2 | Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4838-43. | |||
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