Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0E9UX
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| Former ID |
DIB020680
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| Drug Name |
PF3845
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| Synonyms |
PF-3845; PF 3845
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C24H23F3N4O2
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| Canonical SMILES |
C1CN(CCC1CC2=CC(=CC=C2)OC3=NC=C(C=C3)C(F)(F)F)C(=O)NC4=CN=CC=C4
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| InChI |
1S/C24H23F3N4O2/c25-24(26,27)19-6-7-22(29-15-19)33-21-5-1-3-18(14-21)13-17-8-11-31(12-9-17)23(32)30-20-4-2-10-28-16-20/h1-7,10,14-17H,8-9,11-13H2,(H,30,32)
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| InChIKey |
NBOJHRYUGLRASX-UHFFFAOYSA-N
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| CAS Number |
CAS 1196109-52-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
57248831, 89867374, 122258738, 124971390, 125082367, 125333676, 126731464, 136349540, 136367671, 137275975, 152258571, 160647406, 162011494, 162038083, 162202773, 163137237, 163893798, 164194106, 164764180, 172657437, 174526520, 175612295, 177748654, 178101927, 186007059, 198964764, 215779244, 223370353, 223617455, 223705225, 240486031, 242059920, 251963208, 251971338, 252110163, 252157847, 252160387, 252216045, 252451266
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| ChEBI ID |
CHEBI:95030
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Fatty acid amide hydrolase (FAAH) | Target Info | Inhibitor | [2] |
| BioCyc | Anandamide degradation | |||
| KEGG Pathway | Retrograde endocannabinoid signaling | |||
| Panther Pathway | Anandamide degradation | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5243). | |||
| REF 2 | Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem Biol. 2009 Apr 24;16(4):411-20. | |||
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