Drug Information
Drug General Information | Top | |||
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Drug ID |
D00OAU
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Former ID |
DNC005173
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Drug Name |
GW-328267
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Synonyms |
UNII-DJF621DE4F; DJF621DE4F; GW-328267; CHEMBL186113; GW328267; (S)-2-[[6-Amino-9-[4-(2-ethyl-2H-tetrazole-5-yl)-4-de(hydroxymethyl)-1-deoxy-beta-D-ribofuranose-1-yl]-9H-purine-2-yl]amino]-3-phenyl-1-propanol; (S)-2-((6-Amino-9-(4-(2-ethyl-2H-tetrazole-5-yl)-4-de(hydroxymethyl)-1-deoxy-beta-D-ribofuranose-1-yl)-9H-purine-2-yl)amino)-3-phenyl-1-propanol; SCHEMBL1979140; BDBM50150766; J2.047.755E
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Drug Type |
Small molecular drug
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Indication | Allergic rhinitis [ICD-11: CA08.0] | Phase 1 | [1] | |
Structure |
Download2D MOL |
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Formula |
C21H26N10O4
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Canonical SMILES |
CCN1N=C(N=N1)C2C(C(C(O2)N3C=NC4=C(N=C(N=C43)NC(CC5=CC=CC=C5)CO)N)O)O
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InChI |
1S/C21H26N10O4/c1-2-31-28-18(27-29-31)16-14(33)15(34)20(35-16)30-10-23-13-17(22)25-21(26-19(13)30)24-12(9-32)8-11-6-4-3-5-7-11/h3-7,10,12,14-16,20,32-34H,2,8-9H2,1H3,(H3,22,24,25,26)/t12-,14-,15+,16-,20+/m0/s1
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InChIKey |
FLBKPDIBGNWXMT-NIQZGXKPSA-N
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CAS Number |
CAS 210237-78-8
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Adenosine A2a receptor (ADORA2A) | Target Info | Modulator | [2] |
KEGG Pathway | Rap1 signaling pathway | |||
Calcium signaling pathway | ||||
cAMP signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Vascular smooth muscle contraction | ||||
Parkinson's disease | ||||
Alcoholism | ||||
Pathwhiz Pathway | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | |||
Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
Reactome | NGF-independant TRKA activation | |||
Adenosine P1 receptors | ||||
G alpha (s) signalling events | ||||
Surfactant metabolism | ||||
WikiPathways | Nucleotide GPCRs | |||
Monoamine Transport | ||||
GPCRs, Class A Rhodopsin-like | ||||
NGF signalling via TRKA from the plasma membrane | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT01640990) A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of an Intravenous Infusion of GW328267X in Healthy Volunteers. U.S. National Institutes of Health. | |||
REF 2 | ADENOSINE RECEPTORS AS TARGETS FOR THERAPEUTIC INTERVENTION IN ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
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