Target Information

Target General Information

Top

Target ID

T77365 (Former ID: TTDS00187)

Target Name

Adenosine A2a receptor (ADORA2A)

Synonyms

Adenosine receptor A2a; ADORA2; A2a Adenosine receptor; A(2A) adenosine receptor

Gene Name

ADORA2A

Target Type

Successful target

[1]

Disease

[+] 3 Target-related Diseases

Orthostatic hypotension [ICD-11: BA21]

Parkinsonism [ICD-11: 8A00]

Radionuclide imaging [ICD-11: N.A.]

Function

The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Receptor for adenosine.

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BioChemical Class

GPCR rhodopsin

UniProt ID

AA2AR_HUMAN

Sequence

MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS

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3D Structure

Click to Show 3D Structure of This Target

AlphaFold

HIT2.0 ID

T77M4W

Drugs and Modes of Action

Top

Approved Drug(s)

[+] 3 Approved Drugs

Caffeine

Drug Info

Approved

Orthostatic hypotension

[2], [3]

Istradefylline

Drug Info

Approved

Parkinson disease

[4]

Regadenoson

Drug Info

Approved

Radionuclide imaging

[5], [6]

Clinical Trial Drug(s)

[+] 20 Clinical Trial Drugs

Apadenoson

Drug Info

Phase 3

Coronary artery disease

[7], [8]

Binodenoson

Drug Info

Phase 3

Hypertension

[9], [10]

Tozadenant

Drug Info

Phase 3

Parkinson disease

[11], [12]

AMP-579

Drug Info

Phase 2

Hyperlipidaemia

[13]

AZD4635

Drug Info

Phase 2

Prostate cancer

[14]

BIIB014

Drug Info

Phase 2

Parkinson disease

[15], [16]

Dexefaroxan

Drug Info

Phase 2

Parkinson disease

[17]

MRE-0094

Drug Info

Phase 2

Diabetic foot ulcer

[18]

SCH 420814

Drug Info

Phase 2

Parkinson disease

[16], [19]

Tonapofylline

Drug Info

Phase 2

Acute and chronic heart failure

[20]

UK-432097

Drug Info

Phase 2

Chronic obstructive pulmonary disease

[21], [22]

AB928

Drug Info

Phase 1/2

Metastatic colorectal cancer

[23]

ATL-313

Drug Info

Phase 1/2

Arteriosclerosis

[24], [25]

OPA-6566

Drug Info

Phase 1/2

Glaucoma/ocular hypertension

[26]

PBF509

Drug Info

Phase 1/2

Non-small-cell lung cancer

[27]

V81444

Drug Info

Phase 1/2

Parkinson disease

[28]

EOS100850

Drug Info

Phase 1

Solid tumour/cancer

[29]

GW-328267

Drug Info

Phase 1

Allergic rhinitis

[30]

KF-17837

Drug Info

Phase 1

Parkinson disease

[31]

PBF-999

Drug Info

Phase 1

Solid tumour/cancer

[32]

Discontinued Drug(s)

[+] 5 Discontinued Drugs

PF-1913539

Drug Info

Discontinued in Phase 3

Alzheimer disease

[33]

BVT-115959

Drug Info

Discontinued in Phase 2

Pain

[34]

Lu-AA47070

Drug Info

Discontinued in Phase 1

Parkinson disease

[35]

T-62

Drug Info

Discontinued in Phase 1

Neuropathic pain

[36]

METHYLTHIOADENOSINE

Drug Info

Terminated

Multiple sclerosis

[37]

Mode of Action

[+] 4 Modes of Action

Antagonist

[+] 13 Antagonist drugs

Caffeine

Drug Info

[1], [38]

Tozadenant

Drug Info

[41]

AZD4635

Drug Info

[27]

BIIB014

Drug Info

[16]

SCH 420814

Drug Info

[16]

AB928

Drug Info

[27]

PBF509

Drug Info

[27]

V81444

Drug Info

[48]

EOS100850

Drug Info

[49]

PBF-999

Drug Info

[52]

PF-1913539

Drug Info

[54], [55]

Lu-AA47070

Drug Info

[57]

T-62

Drug Info

[36]

Modulator

[+] 5 Modulator drugs

Istradefylline

Drug Info

[4]

Regadenoson

Drug Info

[39]

AMP-579

Drug Info

[42]

GW-328267

Drug Info

[50]

MSX-3

Drug Info

[105]

Agonist

[+] 9 Agonist drugs

Apadenoson

Drug Info

[7]

Binodenoson

Drug Info

[40]

Dexefaroxan

Drug Info

[43]

MRE-0094

Drug Info

[18]

UK-432097

Drug Info

[45]

ATL-313

Drug Info

[46]

OPA-6566

Drug Info

[47]

BVT-115959

Drug Info

[56]

CGS 21680

Drug Info

[96]

Inhibitor

[+] 225 Inhibitor drugs

Tonapofylline

Drug Info

[44]

KF-17837

Drug Info

[51]

SCH-442416

Drug Info

[53]

ARISTEROMYCIN

Drug Info

[58]

METHYLTHIOADENOSINE

Drug Info

[59]

METRIFUDIL

Drug Info

[60]

ZM-241385

Drug Info

[61]

(1H-Imidazo[4,5-c]quinolin-4-yl)-phenyl-amine HCl

Drug Info

[62]

(2R,3S)-3-(6-Amino-purin-9-yl)-nonan-2-ol

Drug Info

[63]

(3-amino-5-bromobenzofuran-2-yl)(phenyl)methanone

Drug Info

[64]

(E,E)-8-(4-Phenylbutadien-1-yl)caffeine

Drug Info

[65]

(E,E)-8-[4-(3-Bromophenyl)butadien-1-yl]caffeine

Drug Info

[65]

(E,E)-8-[4-(3-Chlorophenyl)butadien-1-yl]caffeine

Drug Info

[65]

(E,E)-8-[4-(3-Fluorophenyl)butadien-1-yl]caffeine

Drug Info

[65]

(S)-DHPA

Drug Info

[66]

(Z)-8-(3-chlorostyryl)caffeine

Drug Info

[65]

1,3,7-Tripropyl-3,7-dihydro-purine-2,6-dione

Drug Info

[67]

1,3,8-Trimethyl-3,7-dihydro-purine-2,6-dione

Drug Info

[68]

1,3-Diallyl-3,7-dihydro-purine-2,6-dione

Drug Info

[69]

1,3-Diallyl-7-methyl-3,7-dihydro-purine-2,6-dione

Drug Info

[67]

1,3-Dibenzyl-3,7-dihydro-purine-2,6-dione

Drug Info

[67]

1,3-Diethyl-3,7-dihydro-purine-2,6-dione

Drug Info

[69]

1,3-Diisobutyl-3,7-dihydro-purine-2,6-dione

Drug Info

[67]

1,3-Dipropyl-3,7-dihydro-purine-2,6-dione

Drug Info

[69]

1,4-diaminoanthracene-9,10-dione

Drug Info

[64]

1-Allyl-3,7-dimethyl-3,7-dihydro-purine-2,6-dione

Drug Info

[67]

1-amino-2,4-bis(phenylthio)anthracene-9,10-dione

Drug Info

[64]

1-amino-2-phenoxyanthracene-9,10-dione

Drug Info

[64]

1-amino-4-chloroanthracene-9,10-dione

Drug Info

[64]

1-amino-4-methoxyanthracene-9,10-dione

Drug Info

[64]

1-aminoanthracene-9,10-dione

Drug Info

[64]

1-Butyl-8-phenyl-3,7-dihydro-purine-2,6-dione

Drug Info

[70]

1-Ethyl-3-methyl-3,7-dihydro-purine-2,6-dione

Drug Info

[67]

1-Methyl-8-phenyl-3,7-dihydro-purine-2,6-dione

Drug Info

[70]

1-METHYLXANTHINE

Drug Info

[69]

1-Phenyl-3-(4-pyridin-2-yl-thiazol-2-yl)-urea

Drug Info

[71]

1H-Imidazo[4,5-c]quinolin-4-ylamine HCl

Drug Info

[62]

2,5'-dichloro-5'-deoxy-N6-cyclopentyladenosine

Drug Info

[72]

2,6,8-triphenyl-9H-purine

Drug Info

[73]

2,6-diphenyl-1-deazapurine

Drug Info

[74]

2,6-diphenyl-8-(1-ethylpropyl)-1-deazapurine

Drug Info

[74]

2,6-diphenyl-8-ethyl-1-deazapurine

Drug Info

[74]

2,6-diphenyl-8-methyl-1-deazapurine

Drug Info

[74]

2,6-diphenyl-8-tButyl-1-deazapurine

Drug Info

[74]

2,6-diphenyl-9H-purine

Drug Info

[73]

2,6-Diphenyl-pyrimidin-4-ylamine

Drug Info

[75]

2,6-dphenyl-8-propyl-1-deazapurine

Drug Info

[74]

2-(1H-benzo[d]imidazol-2-yl)quinoxaline

Drug Info

[76]

2-(2''-indolylethyloxy)adenosine

Drug Info

[77]

2-(2-furyl)-6-(1H-pyrazol-1-yl)pyrimidin-4-amine

Drug Info

[78]

2-(3''(5''-chloro-indolyl)ethyloxy)adenosine

Drug Info

[77]

2-(3''(7''-bromo-indolyl)ethyloxy)adenosine

Drug Info

[77]

2-(3''-(4''-bromo-indolyl)ethyloxy)adenosine

Drug Info

[77]

2-(3''-(5''-bromo-indolyl)ethyloxy)adenosine

Drug Info

[77]

2-(3''-(5''-fluoro-indolyl)ethyloxy)adenosine

Drug Info

[77]

2-(3''-(5''-hydroxyindolyl)ethyloxy)adenosine

Drug Info

[77]

2-(3''-(5''-iodo-indolyl)ethyloxy)adenosine

Drug Info

[77]

2-(3''-(5''-methoxy-indolyl)ethyloxy)adenosine

Drug Info

[77]

2-(3''-(6''-bromo-indolyl)ethyloxy)adenosine

Drug Info

[77]

2-(3''-(6''-chloro-indolyl)ethyloxy)adenosine

Drug Info

[77]

2-(3''-(benzoimidazole-1''-yl)ethyloxy)adenosine

Drug Info

[77]

2-(3''-indolylethyloxy)adenosine

Drug Info

[77]

2-(3''-pyrrolylethyloxy)adenosine

Drug Info

[77]

2-(4-chlorophenyl)-6-phenyl-9H-purine

Drug Info

[73]

2-(4-ethylthiobenzimidazol-2-yl)quinoxaline

Drug Info

[79]

2-(4-hydroxypent-1-yl)-N6-methoxyadenosine

Drug Info

[80]

2-(4-methyl-1H-benzo[d]imidazol-2-yl)quinoxaline

Drug Info

[76]

2-(5-cyano-1-pent-1-ynyl)-N6-methoxyadenosine

Drug Info

[80]

2-(6-amino-8-bromo-9H-purin-9-yl)ethanol

Drug Info

[81]

2-(hex-1-ynyl)-N6-methoxyadenosine

Drug Info

[80]

2-amino-3-(m-tolylamino)naphthalene-1,4-dione

Drug Info

[64]

2-Amino-4,6-di-furan-2-yl-nicotinonitrile

Drug Info

[82]

2-Amino-4,6-di-thiophen-2-yl-nicotinonitrile

Drug Info

[82]

2-Amino-4,6-diphenyl-nicotinonitrile

Drug Info

[82]

2-Amino-4,6-diphenyl-pyrimidin-5-carbonitrile

Drug Info

[75]

2-Amino-4,6-diphenyl-pyrimidine

Drug Info

[75]

2-Amino-4-furan-2-yl-6-phenyl-nicotinonitrile

Drug Info

[82]

2-Amino-4-phenyl-6-thiophen-2-yl-nicotinonitrile

Drug Info

[82]

2-Amino-6-furan-2-yl-4-phenyl-nicotinonitrile

Drug Info

[82]

2-amino-6-phenyl-4-p-tolylnicotinonitrile

Drug Info

[83]

2-Amino-6-phenyl-4-thiophen-2-yl-nicotinonitrile

Drug Info

[82]

2-amino-N-benzyl-6-phenyl-9H-purine-9-carboxamide

Drug Info

[84]

2-chloro-4-(thiazol-2-yl)thieno[3,2-d]pyrimidine

Drug Info

[85]

2-chloro-4-(thiophen-2-yl)thieno[3,2-d]pyrimidine

Drug Info

[85]

2-Cyclopentyl-1H-imidazo[4,5-c]quinolin-4-ylamine

Drug Info

[62]

2-ethyl-4-(furan-2-yl)thieno[3,2-d]pyrimidine

Drug Info

[85]

2-ethyl-4-(furan-3-yl)thieno[3,2-d]pyrimidine

Drug Info

[85]

2-ethyl-4-(pyridin-2-yl)thieno[3,2-d]pyrimidine

Drug Info

[85]

2-ethyl-4-(thiazol-2-yl)thieno[3,2-d]pyrimidine

Drug Info

[85]

2-ethyl-4-(thiophen-2-yl)thieno[3,2-d]pyrimidine

Drug Info

[85]

2-ethynyl-N6-methoxyadenosine

Drug Info

[80]

2-m-tolyl-2H-pyrazolo[3,4-c]quinolin-4-amine

Drug Info

[86]

2-p-tolyl-2H-pyrazolo[3,4-c]quinolin-4-amine

Drug Info

[86]

2-Phenyl-1H-imidazo[4,5-c]quinolin-4-ylamine

Drug Info

[62]

2-phenyl-2H-pyrazolo[3,4-c]quinolin-4-amine

Drug Info

[86]

2-phenylpropoxyadenosine

Drug Info

[77]

2-tolyl-6-phenyl-9H-purine

Drug Info

[73]

2-[(4-acetylphenyl)ethynyl]-N6-methoxyadenosine

Drug Info

[80]

2-[(4-fluorophenyl)ethynyl]-N6-methoxyadenosine

Drug Info

[80]

100

3-Benzyl-7-methyl-[1,8]naphthyridin-4-ol

Drug Info

[87]

101

3-Benzyl-7-methyl-[1,8]naphthyridine-4-thiol

Drug Info

[87]

102

3-Isopropyl-1-methyl-3,7-dihydro-purine-2,6-dione

Drug Info

[67]

103

3-noradamantyl-1,3-dipropylxanthine

Drug Info

[88]

104

4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one

Drug Info

[89]

105

4-(ethylthio)-6-phenyl-1,3,5-triazin-2-amine

Drug Info

[83]

106

4-(furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Drug Info

[90]

107

4-(furan-2-yl)thieno[3,2-d]pyrimidin-2-amine

Drug Info

[84]

108

4-(thiazol-2-yl)thieno[3,2-d]pyrimidin-2-amine

Drug Info

[85]

109

4-Amino-2,6-diphenyl-pyrimidine-5-carbonitrile

Drug Info

[75]

110

4-amino-2-p-tolylisoindoline-1,3-dione

Drug Info

[64]

111

5,7-dibromo-9H-pyrido[3,4-b]indol-6-ol

Drug Info

[91]

112

5,7-diphenyl-3H-imidazo[4,5-b]pyridin-2-ol

Drug Info

[74]

113

5-Azido-6-benzyl-2-methyl-[1,8]naphthyridine

Drug Info

[87]

114

5-Butyl-8-phenyl-3H-[1,2,4]triazolo[5,1-i]purine

Drug Info

[92]

115

6-(furan-2-yl)-9H-purin-2-amine

Drug Info

[90]

116

6-Furan-2-yl-9-phenethyl-9H-purin-2-ylamine

Drug Info

[93]

117

6-Furan-2-yl-9-phenyl-9H-purin-2-ylamine

Drug Info

[93]

118

6-guanidino-2-(3''-indolylethyloxy)adenosine

Drug Info

[77]

119

7-Allyl-1,3-dimethyl-3,7-dihydro-purine-2,6-dione

Drug Info

[67]

120

7-Allyl-1,3-dipropyl-3,7-dihydro-purine-2,6-dione

Drug Info

[67]

121

7-Isopropyl-7H-adenine

Drug Info

[66]

122

7-Propyl-7H-adenine

Drug Info

[66]

123

8-Br-adenine

Drug Info

[66]

124

8-Bromo-9-(2,3-dihydroxypropyl)-9H-adenine

Drug Info

[66]

125

8-Bromo-9-(2-butyl)-9H-adenine

Drug Info

[66]

126

8-Bromo-9-(2-hydroxypropyl)-9H-adenine

Drug Info

[66]

127

8-Bromo-9-(3-hydroxypropyl)-9H-adenine

Drug Info

[66]

128

8-Bromo-9-(but-3-enyl)-9H-adenine

Drug Info

[66]

129

8-Bromo-9-(sec-butyl)-9H-adenine

Drug Info

[66]

130

8-Bromo-9-cyclobutyl-9H-adenine

Drug Info

[66]

131

8-Bromo-9-cyclohexyl-9H-adenine

Drug Info

[66]

132

8-Bromo-9-cyclopentyl-9H-adenine

Drug Info

[66]

133

8-Bromo-9-ethyl-9H-adenine

Drug Info

[66]

134

8-bromo-9-isobutyl-9H-purin-6-amine

Drug Info

[81]

135

8-Bromo-9-isopropyl-9H-adenine

Drug Info

[66]

136

8-Bromo-9-methyl-9H-adenine

Drug Info

[66]

137

8-Bromo-9-phenylethyl-9H-adenine

Drug Info

[66]

138

8-Bromo-9-propyl-9H-adenine

Drug Info

[66]

139

8-PHENYL THEOPHYLLINE

Drug Info

[62]

140

8-Phenyl-1-propyl-3,7-dihydro-purine-2,6-dione

Drug Info

[70]

141

8-propyl-2,6-diphenyl-9H-purine

Drug Info

[73]

142

9-(2-Hydroxyethyl)-9H-adenine

Drug Info

[66]

143

9-(2-Hydroxypropyl)-9H-adenine

Drug Info

[66]

144

9-(3-aminobenzyl)-6-(furan-2-yl)-9H-purin-2-amine

Drug Info

[84]

145

9-(3-Hydroxypropyl)-9H-adenine

Drug Info

[66]

146

9-(3-nitrobenzyl)-6-(furan-2-yl)-9H-purin-2-amine

Drug Info

[84]

147

9-(4-nitrobenzyl)-6-(furan-2-yl)-9H-purin-2-amine

Drug Info

[84]

148

9-(sec-Butyl)-9H-adenine

Drug Info

[66]

149

9-Allyl-8-bromo-9H-adenine

Drug Info

[66]

150

9-benzyl-6-(furan-2-yl)-9H-purin-2-amine

Drug Info

[84]

151

9-Benzyl-8-bromo-9H-adenine

Drug Info

[66]

152

9-BENZYL-9H-ADENINE

Drug Info

[66]

153

9-But-3-enyl-9H-adenine

Drug Info

[66]

154

9-Butyl-9H-adenine

Drug Info

[66]

155

9-Cyclobutyl-9H-adenine

Drug Info

[66]

156

9-Cycloheptyl-9H-adenine

Drug Info

[66]

157

9-Cyclopentyl-9H-adenine

Drug Info

[66]

158

9-Cyclopropyl-9H-adenine

Drug Info

[66]

159

9-Ethyl-8-phenylethynyl-9H-purin-6-ylamine

Drug Info

[94]

160

9-Ethyl-9H-adenine

Drug Info

[66]

161

9-Isopropyl-9H-adenine

Drug Info

[66]

162

9-Methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine

Drug Info

[95]

163

9-Methyl-9H-adenine

Drug Info

[66]

164

9-Phenylethyl-9H-adenine

Drug Info

[66]

165

9-Propyl-9H-adenine

Drug Info

[66]

166

Alloxazine

Drug Info

[95]

167

Cyclohexyl-(2-phenoxy-9H-purin-6-yl)-amine

Drug Info

[97]

168

Cyclohexyl-(2-phenylsulfanyl-9H-purin-6-yl)-amine

Drug Info

[97]

169

Ethyl 5-benzoyl-4-phenylthiazol-2-ylcarbamate

Drug Info

[44]

170

FR-166124

Drug Info

[98]

171

Galangin

Drug Info

[99]

172

GNF-PF-2224

Drug Info

[100]

173

GNF-PF-2700

Drug Info

[81]

174

isobutylmethylxanthine

Drug Info

[67]

175

Isoguanosine

Drug Info

[101]

176

Kuanoniamine D

Drug Info

[102]

177

LUF-5417

Drug Info

[44]

178

LUF-5433

Drug Info

[44]

179

LUF-5437

Drug Info

[71]

180

LUF-5767

Drug Info

[103]

181

LUF-5956

Drug Info

[73]

182

LUF-5957

Drug Info

[73]

183

LUF-5962

Drug Info

[73]

184

LUF-5978

Drug Info

[74]

185

LUF-5980

Drug Info

[74]

186

LUF-5981

Drug Info

[74]

187

Methyl 7-methoxy-4-phenylbenzofuran-2-ylcarbamate

Drug Info

[104]

188

N*6*-Cyclohexyl-N*2*-phenyl-9H-purine-2,6-diamine

Drug Info

[97]

189

N-(2,6-diphenylpyrimidin-4-yl)-2-ethylbutyramide

Drug Info

[103]

190

N-(2,6-diphenylpyrimidin-4-yl)-3-methylbutyramide

Drug Info

[103]

191

N-(2,6-diphenylpyrimidin-4-yl)acetamide

Drug Info

[103]

192

N-(2,6-diphenylpyrimidin-4-yl)butyramide

Drug Info

[103]

193

N-(2,6-diphenylpyrimidin-4-yl)isobutyramide

Drug Info

[103]

194

N-(2,6-diphenylpyrimidin-4-yl)propionamide

Drug Info

[103]

195

N-(2-(furan-2-yl)-3,4'-bipyridin-6-yl)acetamide

Drug Info

[106]

196

N-(3-Phenyl-[1,2,4]thiadiazol-5-yl)-benzamide

Drug Info

[71]

197

N-(4,6-diphenylpyrimidin-2-yl)propionamide

Drug Info

[103]

198

N-(4-Pyridin-2-yl-thiazol-2-yl)-benzamide

Drug Info

[71]

199

N-(5-Benzoyl-4-phenylthiazol-2-yl)benzamide

Drug Info

[44]

200

N-(7-methoxy-4-phenylbenzofuran-2-yl)acetamide

Drug Info

[104]

201

N6-((+/-)-endo-norborn-2-yl)adenosine

Drug Info

[72]

202

N6-(4-hydroxybenzyl)adenine riboside

Drug Info

[107]

203

N6-CYCLOPENTYLADENOSINE

Drug Info

[44]

204

N6-methoxy-2-phenylethynyladenosine

Drug Info

[80]

205

N6-methoxy-2-[(2-pyridinyl)ethynyl]adenosine

Drug Info

[80]

206

N6-methoxy-2-[(3-pyridinyl)ethynyl]-adenosine

Drug Info

[80]

207

N6-methoxy-2-[(4-methoxyphenyl)ethynyl]adenosine

Drug Info

[80]

208

N6-methoxy-2-[(4-pentylphenyl)ethynyl]adenosine

Drug Info

[80]

209

N6-methoxy-2-[(4-pyridinyl)ethynyl]adenosine

Drug Info

[80]

210

N6-methoxy-2-[2-(trimethylsilyl)ethynyl]adenosine

Drug Info

[80]

211

N6-[(4-Amino)-phenyl]-9-benzyl-2-phenyladenine

Drug Info

[108]

212

N6-[(4-Nitro)-phenyl]-9-benzyl-2-phenyladenine

Drug Info

[108]

213

PD-115199

Drug Info

[109]

214

Phenyl 7-methoxy-4-phenylbenzofuran-2-ylcarbamate

Drug Info

[104]

215

Phenyl(2-(trifluoromethyl)quinolin-4-yl)methanol

Drug Info

[110]

216

PSB-0788

Drug Info

[111]

217

PSB-09120

Drug Info

[111]

218

PSB-601

Drug Info

[111]

219

R-N6-(phenylisopropyl)adenosine

Drug Info

[77]

220

SB-298

Drug Info

[111]

221

SCH-63390

Drug Info

[112]

222

ST-1535

Drug Info

[82]

223

[3H]CCPA

Drug Info

[113]

224

[3H]NECA

Drug Info

[114]

225

[3H]OSIP339391

Drug Info

[81]

Chemical Structure based Activity Landscape of Target

Top

Drug Property Profile of Target

Top

(1) Molecular Weight (mw) based Drug Clustering

(2) Octanol/Water Partition Coefficient (xlogp) based Drug Clustering

(3) Hydrogen Bond Donor Count (hbonddonor) based Drug Clustering

(4) Hydrogen Bond Acceptor Count (hbondacc) based Drug Clustering

(5) Rotatable Bond Count (rotbonds) based Drug Clustering

(6) Topological Polar Surface Area (polararea) based Drug Clustering

"RO5" indicates the cutoff set by lipinski's rule of five; "D123AB" colored in GREEN denotes the no violation of any cutoff in lipinski's rule of five; "D123AB" colored in PURPLE refers to the violation of only one cutoff in lipinski's rule of five; "D123AB" colored in BLACK represents the violation of more than one cutoffs in lipinski's rule of five

Co-Targets

Top

Co-Targets

Co-Targets Info

Target Poor or Non Binders

Top

Target Poor or Non Binders

Target Poor or Non Binders Info

Target Regulators

Top

Target-interacting Proteins

Target-interacting Proteins Info

Target Affiliated Biological Pathways

Top

KEGG Pathway

[+] 7 KEGG Pathways

Rap1 signaling pathway

Calcium signaling pathway

cAMP signaling pathway

Neuroactive ligand-receptor interaction

Vascular smooth muscle contraction

Parkinson's disease

Alcoholism

Pathwhiz Pathway

[+] 1 Pathwhiz Pathways

Intracellular Signalling Through Adenosine Receptor A2a and Adenosine

PID Pathway

[+] 1 PID Pathways

HIF-2-alpha transcription factor network

Reactome

[+] 4 Reactome Pathways

NGF-independant TRKA activation

Adenosine P1 receptors

G alpha (s) signalling events

Surfactant metabolism

WikiPathways

[+] 7 WikiPathways

Nucleotide GPCRs

Monoamine Transport

GPCRs, Class A Rhodopsin-like

NGF signalling via TRKA from the plasma membrane

GPCR ligand binding

GPCR downstream signaling

GPCRs, Other

Target-Related Models and Studies

Top

Target Validation

Target Validation Info

Target QSAR Model

References

Top

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