Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0H5HP
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| Former ID |
DNC010364
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| Drug Name |
1-amino-4-chloroanthracene-9,10-dione
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| Synonyms |
1-Amino-4-chloroanthraquinone; 1-amino-4-chloroanthracene-9,10-dione; 2872-47-1; 4-Chloro-1-aminoanthraquinone; 4-Amino-4-chloroanthraquinone; ANTHRAQUINONE, 1-AMINO-4-CHLORO-; C.I. 62805; NSC 39927; BRN 0916373; 1-Amino-4-chloro-9,10-anthracenedione; 9,10-Anthracenedione, 1-amino-4-chloro-; CHEMBL603094; NSC39927; AC1L2AVQ; 9, 1-amino-4-chloro-; 4-14-00-00440 (Beilstein Handbook Reference); SCHEMBL5109323; CTK4G1984; DTXSID50182880; MolPort-000-643-769; AWACQBFBMROGQC-UHFFFAOYSA-N; ZINC4792024; NSC-39927; BDBM50306769; STK238272
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C14H8ClNO2
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| Canonical SMILES |
C1=CC=C2C(=C1)C(=O)C3=C(C=CC(=C3C2=O)Cl)N
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| InChI |
1S/C14H8ClNO2/c15-9-5-6-10(16)12-11(9)13(17)7-3-1-2-4-8(7)14(12)18/h1-6H,16H2
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| InChIKey |
AWACQBFBMROGQC-UHFFFAOYSA-N
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| CAS Number |
CAS 2872-47-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adenosine A2a receptor (ADORA2A) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Rap1 signaling pathway | |||
| Calcium signaling pathway | ||||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Vascular smooth muscle contraction | ||||
| Parkinson's disease | ||||
| Alcoholism | ||||
| Pathwhiz Pathway | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Reactome | NGF-independant TRKA activation | |||
| Adenosine P1 receptors | ||||
| G alpha (s) signalling events | ||||
| Surfactant metabolism | ||||
| WikiPathways | Nucleotide GPCRs | |||
| Monoamine Transport | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| NGF signalling via TRKA from the plasma membrane | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. J Med Chem. 2010 Feb 25;53(4):1799-809. | |||
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