Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D08GLJ
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| Former ID |
DNC012414
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| Drug Name |
1,3,8-Trimethyl-3,7-dihydro-purine-2,6-dione
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| Synonyms |
830-65-9; 8-Methyltheophylline; 1,3,8-Trimethyl-1H-purine-2,6(3H,7H)-dione; Theophylline, 8-methyl-; Xanthine, 1,3,8-trimethyl-; 1,3,8-Trimethyl-2,6-dioxopurine; 1,3,8-trimethylxanthine; NSC 14289; 1,3,8-trimethyl-3,9-dihydro-1h-purine-2,6-dione; CHEMBL89062; 3,7-Dihydro-1,3,8-trimethyl-1H-purine-2,6-dione; 1,3,8-trimethyl-2,3,6,9-tetrahydro-1H-purine-2,6-dione; 8-methyltheophyllin; NSC14289; 8-Methyltheophyline; AC1Q6LAN; AC1L3TFC; Xanthine,3,8-trimethyl-; 1,3,8-Trimethyl-3,7-dihydro-purine-2,6-dione; SCHEMBL461786
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C8H10N4O2
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| Canonical SMILES |
CC1=NC2=C(N1)C(=O)N(C(=O)N2C)C
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| InChI |
1S/C8H10N4O2/c1-4-9-5-6(10-4)11(2)8(14)12(3)7(5)13/h1-3H3,(H,9,10)
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| InChIKey |
WZBKGWBHAPBSBF-UHFFFAOYSA-N
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| CAS Number |
CAS 830-65-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adenosine A2a receptor (ADORA2A) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Rap1 signaling pathway | |||
| Calcium signaling pathway | ||||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Vascular smooth muscle contraction | ||||
| Parkinson's disease | ||||
| Alcoholism | ||||
| Pathwhiz Pathway | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Reactome | NGF-independant TRKA activation | |||
| Adenosine P1 receptors | ||||
| G alpha (s) signalling events | ||||
| Surfactant metabolism | ||||
| WikiPathways | Nucleotide GPCRs | |||
| Monoamine Transport | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| NGF signalling via TRKA from the plasma membrane | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors. J Med Chem. 1985 Apr;28(4):487-92. | |||
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