Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0XE1C
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| Former ID |
DNAP001677
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| Drug Name |
Regadenoson
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| Synonyms |
Lexiscan (TN)
Click to Show/Hide
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| Drug Type |
Small molecular drug
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| Indication | Radionuclide imaging [ICD-11: N.A.] | Approved | [1], [2] | |
| Company |
CV Therapeutics
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| Structure |
 |
Download2D MOL |
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| Formula |
C15H18N8O5
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| Canonical SMILES |
CNC(=O)C1=CN(N=C1)C2=NC(=C3C(=N2)N(C=N3)C4C(C(C(O4)CO)O)O)N
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| InChI |
1S/C15H18N8O5/c1-17-13(27)6-2-19-23(3-6)15-20-11(16)8-12(21-15)22(5-18-8)14-10(26)9(25)7(4-24)28-14/h2-3,5,7,9-10,14,24-26H,4H2,1H3,(H,17,27)(H2,16,20,21)/t7-,9-,10-,14-/m1/s1
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| InChIKey |
LZPZPHGJDAGEJZ-AKAIJSEGSA-N
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| CAS Number |
CAS 313348-27-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9374242, 12015422, 14854126, 14927662, 30422403, 47207372, 50076240, 57399831, 75022119, 103113812, 103314999, 104012380, 113468422, 117572229, 126680726, 135140826, 137263912, 139484166, 162835188, 164764795, 170465244, 171579236, 175267893, 175427061, 178102231, 179150304, 203355938, 223667522, 226973662, 244376244, 251971060, 252451521
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| ChEBI ID |
CHEBI:135613
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| ADReCS Drug ID | BADD_D01921 | |||
| SuperDrug ATC ID |
C01EB21
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adenosine A2a receptor (ADORA2A) | Target Info | Modulator | [3] |
| KEGG Pathway | Rap1 signaling pathway | |||
| Calcium signaling pathway | ||||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Vascular smooth muscle contraction | ||||
| Parkinson's disease | ||||
| Alcoholism | ||||
| Pathwhiz Pathway | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Reactome | NGF-independant TRKA activation | |||
| Adenosine P1 receptors | ||||
| G alpha (s) signalling events | ||||
| Surfactant metabolism | ||||
| WikiPathways | Nucleotide GPCRs | |||
| Monoamine Transport | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| NGF signalling via TRKA from the plasma membrane | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5596). | |||
| REF 2 | 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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