Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0M3CG
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| Former ID |
DNC007201
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| Drug Name |
R-N6-(phenylisopropyl)adenosine
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| Synonyms |
(R)-N-(1-Methyl-2-phenylethyl)adenosine; (R)-PIA; 38594-96-6; L-PIA; l-Phenylisopropyladenosine; Phenylisopropyladenosine, L-; N6-D-Phenylisopropyladenosine; (R)-(Phenylisopropyl)adenosine; (-)-(Phenylisopropyl)adenosine; N6-(R)-Phenylisopropyladenosine; (R)-N6-Phenylisopropyladenosine; (-)-PIA; L-2-N6-(Phenylisopropyl)adenosine; l-N(sup 6)-Phenylisopropyladenosine; EINECS 254-028-5; TH 162; (R)-N6-(2-Phenylisopropyl)adenosine; BRN 4912716; (-)-N-(alpha-Methylphenethyl)adensoine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C19H23N5O4
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| Canonical SMILES |
CC(CC1=CC=CC=C1)NC2=C3C(=NC=N2)N(C=N3)C4C(C(C(O4)CO)O)O
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| InChI |
1S/C19H23N5O4/c1-11(7-12-5-3-2-4-6-12)23-17-14-18(21-9-20-17)24(10-22-14)19-16(27)15(26)13(8-25)28-19/h2-6,9-11,13,15-16,19,25-27H,7-8H2,1H3,(H,20,21,23)/t11-,13-,15-,16-,19-/m1/s1
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| InChIKey |
RIRGCFBBHQEQQH-SSFGXONLSA-N
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| CAS Number |
CAS 38594-96-6
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| PubChem Compound ID | ||||
| References | Top | |||
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| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 414). | |||
| REF 2 | Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. | |||
| REF 3 | Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):1-9. | |||
| REF 4 | Adenosine receptor activation in human fibroblasts: nucleoside agonists and antagonists. Can J Physiol Pharmacol. 1980 Jun;58(6):673-91. | |||
| REF 5 | Structure-activity relationships for 2-substituted adenosines at A1 and A2 adenosine receptors. Pharmacology. 1993;46(2):91-100. | |||
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