Target Information

Target General Information

Top

Target ID

T92072 (Former ID: TTDS00186)

Target Name

Adenosine A1 receptor (ADORA1)

Synonyms

Adenosine receptor A1; A(1) adenosine receptor

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Gene Name

ADORA1

Target Type

Successful target

[1]

Disease

[+] 1 Target-related Diseases

Orthostatic hypotension [ICD-11: BA21]

Function

The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Receptor for adenosine.

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BioChemical Class

GPCR rhodopsin

UniProt ID

AA1R_HUMAN

Sequence

MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD

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3D Structure

Click to Show 3D Structure of This Target

PDB

ADReCS ID

BADD_A01328 ; BADD_A01334

HIT2.0 ID

T35LKG

Drugs and Modes of Action

Top

Approved Drug(s)

[+] 1 Approved Drugs

Caffeine

Drug Info

Approved

Orthostatic hypotension

[2], [3]

Clinical Trial Drug(s)

[+] 13 Clinical Trial Drugs

Rolofylline

Drug Info

Phase 3

Heart failure

[4], [5]

AMP-579

Drug Info

Phase 2

Hyperlipidaemia

[6]

Apaxifylline

Drug Info

Phase 2

Cognitive impairment

[7]

BAY 1067197

Drug Info

Phase 2

Heart failure

[8]

Capadenoson

Drug Info

Phase 2

Atrial fibrillation

[9]

DTI-0009

Drug Info

Phase 2

Atrial fibrillation

[10]

SELODENOSON

Drug Info

Phase 2

Cardiac arrhythmias

[10]

SLV320

Drug Info

Phase 2

Heart failure

[11], [12]

Tonapofylline

Drug Info

Phase 2

Acute and chronic heart failure

[13]

INO-8875

Drug Info

Phase 1/2

Glaucoma/ocular hypertension

[14]

AST-004

Drug Info

Phase 1

Stroke

[15]

GS 9667

Drug Info

Phase 1

Hypertriglyceridemia

[16], [17]

KF-17837

Drug Info

Phase 1

Parkinson disease

[18]

Discontinued Drug(s)

[+] 11 Discontinued Drugs

CVT-124

Drug Info

Discontinued in Phase 3

Autoimmune diabetes

[19]

N-0861

Drug Info

Discontinued in Phase 3

Cardiac disease

[20]

Tecadenoson

Drug Info

Discontinued in Phase 3

Cardiac arrhythmias

[21], [22]

BRL-61063

Drug Info

Discontinued in Phase 2

Allergy

[23]

FK-352

Drug Info

Discontinued in Phase 2

Hypertension

[24]

FK-453

Drug Info

Discontinued in Phase 2

Renal failure

[25], [26]

FK-838

Drug Info

Discontinued in Phase 2

Hypertension

[27]

GW-493838

Drug Info

Discontinued in Phase 2

Neuropathic pain

[28]

GR-79236

Drug Info

Discontinued in Phase 1

Diabetic complication

[29], [30]

SDZ-WAG-994

Drug Info

Discontinued in Phase 1

Hypertension

[31]

METHYLTHIOADENOSINE

Drug Info

Terminated

Multiple sclerosis

[33]

Preclinical Drug(s)

[+] 1 Preclinical Drugs

BAY 60-6583

Drug Info

Preclinical

Myocardial ischemia

[32]

Mode of Action

[+] 4 Modes of Action

Antagonist

[+] 42 Antagonist drugs

Caffeine

Drug Info

[1], [34]

Rolofylline

Drug Info

[5]

Apaxifylline

Drug Info

[36]

SLV320

Drug Info

[12]

CVT-124

Drug Info

[50], [51]

N-0861

Drug Info

[52]

FK-352

Drug Info

[54]

(E)-8-(3-chlorostyryl)-caffeine

Drug Info

[66]

4-Ethoxy-7-((E)-styryl)-furo[3,2-g]chromen-5-one

Drug Info

[97]

8-cyclopentyltheophylline

Drug Info

[102]

AS100

Drug Info

[108]

AS70

Drug Info

[108]

AS99

Drug Info

[108]

ATL802

Drug Info

[109]

CPFPX

Drug Info

[112]

flavone

Drug Info

[97]

FR194921

Drug Info

[116]

isobutylmethylxanthine

Drug Info

[122], [123]

KF26777

Drug Info

[125]

MRE 2029F20

Drug Info

[130]

MRE 3008F20

Drug Info

[111]

MRS1041

Drug Info

[97]

MRS1042

Drug Info

[97]

MRS1062

Drug Info

[97]

MRS1065

Drug Info

[97]

MRS1084

Drug Info

[97]

MRS1086

Drug Info

[97]

MRS1093

Drug Info

[97]

MRS1132

Drug Info

[97]

MRS1191

Drug Info

[127]

MRS1523

Drug Info

[127]

MRS923

Drug Info

[97]

MRS928

Drug Info

[97]

PSB-10

Drug Info

[140]

PSB-11

Drug Info

[140]

PSB36

Drug Info

[141]

PSB603

Drug Info

[139]

sakuranetin

Drug Info

[97]

VUF5574

Drug Info

[147]

WRC-0571

Drug Info

[148]

xanthine amine congener

Drug Info

[122]

[3H]DPCPX

Drug Info

[149]

Modulator

[+] 7 Modulator drugs

AMP-579

Drug Info

[35]

BAY 1067197

Drug Info

[37]

FK-453

Drug Info

[55]

FK-838

Drug Info

[56]

GW-493838

Drug Info

[38]

L-97-1 intravenous

Drug Info

[127]

Paeoniflorin

Drug Info

[127]

Agonist

[+] 23 Agonist drugs

Capadenoson

Drug Info

[38]

DTI-0009

Drug Info

[39], [40]

SELODENOSON

Drug Info

[39], [40], [41]

INO-8875

Drug Info

[44]

AST-004

Drug Info

[45]

GS 9667

Drug Info

[46]

PMID27387065-Compound-6

Drug Info

[49]

Tecadenoson

Drug Info

[50], [51]

GR-79236

Drug Info

[57]

SDZ-WAG-994

Drug Info

[58]

BAY 60-6583

Drug Info

[59]

(R,S)-PHPNECA

Drug Info

[67]

(S)-PIA

Drug Info

[68]

2-chloroadenosine

Drug Info

[90]

5-Cl-5-deoxy-(+/-)-ENBA

Drug Info

[75]

CP608,039

Drug Info

[111]

LUF5831

Drug Info

[129]

MRS5151

Drug Info

[131]

N(6)-cyclohexyladenosine

Drug Info

[132]

PENECA

Drug Info

[67]

TCPA

Drug Info

[144]

[3H]CCPA

Drug Info

[142], [73]

[3H]HEMADO

Drug Info

[150]

Inhibitor

[+] 239 Inhibitor drugs

Tonapofylline

Drug Info

[42], [43]

KF-17837

Drug Info

[47]

SCH-442416

Drug Info

[48]

BRL-61063

Drug Info

[53]

ARISTEROMYCIN

Drug Info

[60]

METHYLTHIOADENOSINE

Drug Info

[61]

METRIFUDIL

Drug Info

[62]

ZM-241385

Drug Info

[63]

(1-Phenyl-propyl)-(9-phenyl-9H-purin-6-yl)-amine

Drug Info

[64]

(1H-Imidazo[4,5-c]quinolin-4-yl)-phenyl-amine HCl

Drug Info

[65]

(2-Chloro-9-methyl-9H-purin-6-yl)-phenyl-amine

Drug Info

[64]

(9-Methyl-9H-purin-6-yl)-phenyl-amine

Drug Info

[64]

1,3-Diallyl-3,7-dihydro-purine-2,6-dione

Drug Info

[69]

1,3-Diethyl-3,7-dihydro-purine-2,6-dione

Drug Info

[69]

1,3-Diisobutyl-3,7-dihydro-purine-2,6-dione

Drug Info

[69]

1,3-Dipropyl-3,7-dihydro-purine-2,6-dione

Drug Info

[69]

1-Butyl-8-phenyl-3,7-dihydro-purine-2,6-dione

Drug Info

[70]

1-Methyl-8-phenyl-3,7-dihydro-purine-2,6-dione

Drug Info

[71]

1-METHYLXANTHINE

Drug Info

[69]

1-Propyl-3,7-dihydro-purine-2,6-dione

Drug Info

[72]

1H-Imidazo[4,5-c]quinolin-4-ylamine HCl

Drug Info

[65]

2'-Me-tecadenoson

Drug Info

[73]

2,4-Dichloro-N-(4-phenyl-thiazol-2-yl)-benzamide

Drug Info

[74]

2,5'-dichloro-5'-deoxy-N6-cyclopentyladenosine

Drug Info

[75]

2,6,8-triphenyl-9H-purine

Drug Info

[76]

2,6-bis(4-tolyl)-9H-purine

Drug Info

[76]

2,6-dimethyl-8-ethyl-1-deazapurine

Drug Info

[77]

2,6-diphenyl-1-deazapurine

Drug Info

[77]

2,6-diphenyl-8-(1-ethylpropyl)-1-deazapurine

Drug Info

[77]

2,6-diphenyl-8-ethyl-1-deazapurine

Drug Info

[77]

2,6-diphenyl-8-methyl-1-deazapurine

Drug Info

[77]

2,6-diphenyl-8-tButyl-1-deazapurine

Drug Info

[77]

2,6-diphenyl-9H-purine

Drug Info

[76]

2,6-Diphenyl-pyrimidin-4-ylamine

Drug Info

[78]

2,6-dphenyl-8-propyl-1-deazapurine

Drug Info

[77]

2-(1H-benzo[d]imidazol-2-yl)quinoxaline

Drug Info

[79]

2-(2''-indolylethyloxy)adenosine

Drug Info

[80]

2-(2-furyl)-6-(1H-pyrazol-1-yl)pyrimidin-4-amine

Drug Info

[81]

2-(3''(5''-chloro-indolyl)ethyloxy)adenosine

Drug Info

[80]

2-(3''(7''-bromo-indolyl)ethyloxy)adenosine

Drug Info

[80]

2-(3''-(4''-bromo-indolyl)ethyloxy)adenosine

Drug Info

[80]

2-(3''-(5''-bromo-indolyl)ethyloxy)adenosine

Drug Info

[80]

2-(3''-(5''-fluoro-indolyl)ethyloxy)adenosine

Drug Info

[80]

2-(3''-(5''-hydroxyindolyl)ethyloxy)adenosine

Drug Info

[80]

2-(3''-(5''-iodo-indolyl)ethyloxy)adenosine

Drug Info

[80]

2-(3''-(5''-methoxy-indolyl)ethyloxy)adenosine

Drug Info

[80]

2-(3''-(6''-bromo-indolyl)ethyloxy)adenosine

Drug Info

[80]

2-(3''-(6''-chloro-indolyl)ethyloxy)adenosine

Drug Info

[80]

2-(3''-indolylethyloxy)adenosine

Drug Info

[80]

2-(3''-pyrrolylethyloxy)adenosine

Drug Info

[80]

2-(4-chloro-1H-benzo[d]imidazol-2-yl)quinoxaline

Drug Info

[82]

2-(4-chlorophenyl)-6-phenyl-9H-purine

Drug Info

[76]

2-(4-ethylthiobenzimidazol-2-yl)quinoxaline

Drug Info

[82]

2-(4-hydroxypent-1-yl)-N6-methoxyadenosine

Drug Info

[83]

2-(4-methoxyphenyl)-6-phenyl-9H-purine

Drug Info

[76]

2-(4-methyl-1H-benzo[d]imidazol-2-yl)quinoxaline

Drug Info

[79]

2-(5-cyano-1-pent-1-ynyl)-N6-methoxyadenosine

Drug Info

[83]

2-(6-amino-8-bromo-9H-purin-9-yl)ethanol

Drug Info

[84]

2-(6-Cyclopentylamino-purin-9-yl)-ethanol

Drug Info

[64]

2-(hex-1-ynyl)-N6-methoxyadenosine

Drug Info

[83]

2-Amino-4,6-di-furan-2-yl-nicotinonitrile

Drug Info

[85]

2-Amino-4,6-di-thiophen-2-yl-nicotinonitrile

Drug Info

[85]

2-Amino-4,6-diphenyl-nicotinonitrile

Drug Info

[85]

2-Amino-4,6-diphenyl-pyrimidin-5-carbonitrile

Drug Info

[78]

2-Amino-4,6-diphenyl-pyrimidine

Drug Info

[78]

2-Amino-4-furan-2-yl-6-phenyl-nicotinonitrile

Drug Info

[85]

2-Amino-4-phenyl-6-thiophen-2-yl-nicotinonitrile

Drug Info

[85]

2-Amino-6-furan-2-yl-4-phenyl-nicotinonitrile

Drug Info

[85]

2-amino-6-phenyl-4-p-tolylnicotinonitrile

Drug Info

[86]

2-Amino-6-phenyl-4-thiophen-2-yl-nicotinonitrile

Drug Info

[85]

2-amino-N-benzyl-6-phenyl-9H-purine-9-carboxamide

Drug Info

[87]

2-azido-N6-methyl-9-(beta-D-ribofuranosyl)adenine

Drug Info

[88]

2-chloro-2'-C-methyl-tecadenoson

Drug Info

[73]

2-chloro-4-(thiazol-2-yl)thieno[3,2-d]pyrimidine

Drug Info

[89]

2-chloro-4-(thiophen-2-yl)thieno[3,2-d]pyrimidine

Drug Info

[89]

2-Cyclopentyl-1H-imidazo[4,5-c]quinolin-4-ylamine

Drug Info

[65]

2-ethyl-4-(furan-2-yl)thieno[3,2-d]pyrimidine

Drug Info

[89]

2-ethyl-4-(furan-3-yl)thieno[3,2-d]pyrimidine

Drug Info

[89]

2-ethyl-4-(pyridin-2-yl)thieno[3,2-d]pyrimidine

Drug Info

[89]

2-ethyl-4-(thiazol-2-yl)thieno[3,2-d]pyrimidine

Drug Info

[89]

2-ethyl-4-(thiophen-2-yl)thieno[3,2-d]pyrimidine

Drug Info

[89]

2-ethynyl-N6-methoxyadenosine

Drug Info

[83]

2-m-tolyl-2H-pyrazolo[3,4-c]quinolin-4(5H)-one

Drug Info

[91]

2-m-tolyl-2H-pyrazolo[3,4-c]quinolin-4-amine

Drug Info

[91]

2-p-tolyl-2H-pyrazolo[3,4-c]quinolin-4(5H)-one

Drug Info

[91]

2-p-tolyl-2H-pyrazolo[3,4-c]quinolin-4-amine

Drug Info

[91]

2-Phenyl-1H-imidazo[4,5-c]quinolin-4-ylamine

Drug Info

[65]

2-phenyl-2H-pyrazolo[3,4-c]quinolin-4(5H)-one

Drug Info

[91]

2-phenyl-2H-pyrazolo[3,4-c]quinolin-4-amine

Drug Info

[91]

2-phenylpropoxyadenosine

Drug Info

[80]

2-tolyl-6-phenyl-9H-purine

Drug Info

[76]

2-[(4-acetylphenyl)ethynyl]-N6-methoxyadenosine

Drug Info

[83]

2-[(4-fluorophenyl)ethynyl]-N6-methoxyadenosine

Drug Info

[83]

3,4-Dichloro-N-(4-phenyl-thiazol-2-yl)-benzamide

Drug Info

[74]

3-(3-chloro-1H-pyrazol-5-yl)quinoxalin-2(1H)-one

Drug Info

[79]

3-Benzyl-7-methyl-[1,8]naphthyridin-4-ol

Drug Info

[92]

3-Benzyl-7-methyl-[1,8]naphthyridine-4-thiol

Drug Info

[92]

3-Chloro-N-(4-phenyl-thiazol-2-yl)-benzamide

Drug Info

[74]

3-noradamantyl-1,3-dipropylxanthine

Drug Info

[93]

100

4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one

Drug Info

[94]

101

4-(ethylthio)-6-phenyl-1,3,5-triazin-2-amine

Drug Info

[86]

102

4-(furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Drug Info

[95]

103

4-(furan-2-yl)thieno[3,2-d]pyrimidin-2-amine

Drug Info

[87]

104

4-(thiazol-2-yl)thieno[3,2-d]pyrimidin-2-amine

Drug Info

[89]

105

4-Amino-2,6-diphenyl-pyrimidine-5-carbonitrile

Drug Info

[78]

106

4-Bromo-N-(4-phenyl-thiazol-2-yl)-benzamide

Drug Info

[74]

107

4-Chloro-7-methyl-2-phenyl-[1,8]naphthyridine

Drug Info

[96]

108

4-Chloro-N-(4-phenyl-thiazol-2-yl)-benzamide

Drug Info

[74]

109

4-Methoxy-N-(3-phenyl-isoquinolin-1-yl)-benzamide

Drug Info

[74]

110

4-Methyl-N-(4-phenyl-thiazol-2-yl)-benzamide

Drug Info

[74]

111

4-Nitro-N-(4-phenyl-thiazol-2-yl)-benzamide

Drug Info

[74]

112

4-tert-Butyl-N-(4-phenyl-thiazol-2-yl)-benzamide

Drug Info

[74]

113

5,7-dibromo-9H-pyrido[3,4-b]indol-6-ol

Drug Info

[98]

114

5,7-diphenyl-3H-imidazo[4,5-b]pyridin-2-ol

Drug Info

[77]

115

6-(furan-2-yl)-9H-purin-2-amine

Drug Info

[95]

116

6-ethylamino-2-(3''-indolyl)ethyloxy)adenosine

Drug Info

[80]

117

6-guanidino-2-(3''-indolylethyloxy)adenosine

Drug Info

[80]

118

7-(3,6,9,12-tetraoxatricos-22-enyl)theophylline

Drug Info

[99]

119

7-Bromo-2-phenyl-[1,8]naphthyridin-4-ol

Drug Info

[100]

120

7-Chloro-2-phenyl-[1,8]naphthyridin-4-ol

Drug Info

[100]

121

7-Dimethylamino-2-phenyl-[1,8]naphthyridin-4-ol

Drug Info

[100]

122

7-Methyl-2-propyl-[1,8]naphthyridin-4-ol

Drug Info

[100]

123

8-Bromo-9-(2,3-dihydroxypropyl)-9H-adenine

Drug Info

[101]

124

8-Bromo-9-(2-butyl)-9H-adenine

Drug Info

[101]

125

8-Bromo-9-(2-hydroxypropyl)-9H-adenine

Drug Info

[101]

126

8-Bromo-9-(3-hydroxypropyl)-9H-adenine

Drug Info

[101]

127

8-Bromo-9-(but-3-enyl)-9H-adenine

Drug Info

[101]

128

8-Bromo-9-(sec-butyl)-9H-adenine

Drug Info

[101]

129

8-Bromo-9-cyclobutyl-9H-adenine

Drug Info

[101]

130

8-Bromo-9-cyclohexyl-9H-adenine

Drug Info

[101]

131

8-Bromo-9-cyclopentyl-9H-adenine

Drug Info

[101]

132

8-Bromo-9-ethyl-9H-adenine

Drug Info

[101]

133

8-bromo-9-isobutyl-9H-purin-6-amine

Drug Info

[84]

134

8-Bromo-9-isopropyl-9H-adenine

Drug Info

[101]

135

8-Bromo-9-methyl-9H-adenine

Drug Info

[101]

136

8-Bromo-9-phenylethyl-9H-adenine

Drug Info

[101]

137

8-Bromo-9-propyl-9H-adenine

Drug Info

[101]

138

8-cyclohexyl-6-(4-tolyl)-2-phenyl-9H-purine

Drug Info

[76]

139

8-PHENYL THEOPHYLLINE

Drug Info

[65]

140

8-Phenyl-1-propyl-3,7-dihydro-purine-2,6-dione

Drug Info

[103]

141

8-Phenyl-3,7-dihydro-purine-2,6-dione

Drug Info

[103]

142

8-propyl-2,6-diphenyl-9H-purine

Drug Info

[76]

143

9-(3-aminobenzyl)-6-(furan-2-yl)-9H-purin-2-amine

Drug Info

[87]

144

9-(3-nitrobenzyl)-6-(furan-2-yl)-9H-purin-2-amine

Drug Info

[87]

145

9-(4-nitrobenzyl)-6-(furan-2-yl)-9H-purin-2-amine

Drug Info

[87]

146

9-Allyl-8-bromo-9H-adenine

Drug Info

[101]

147

9-benzyl-6-(furan-2-yl)-9H-purin-2-amine

Drug Info

[87]

148

9-Benzyl-8-bromo-9H-adenine

Drug Info

[101]

149

9-Cyclobutyl-9H-adenine

Drug Info

[101]

150

9-Cyclopentyl-9H-adenine

Drug Info

[64]

151

9-Ethyl-8-phenylethynyl-9H-purin-6-ylamine

Drug Info

[104]

152

9-Ethyl-9H-adenine

Drug Info

[101]

153

9-Isopropyl-9H-adenine

Drug Info

[101]

154

9-Methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine

Drug Info

[105]

155

9-Methyl-9H-adenine

Drug Info

[61]

156

9-Phenyl-9H-purin-6-ylamine

Drug Info

[64]

157

9-Propyl-9H-adenine

Drug Info

[101]

158

A-987306

Drug Info

[106]

159

Anthoptilide C

Drug Info

[107]

160

Cirsimarin

Drug Info

[110]

161

Cyclohexyl-(2-phenylsulfanyl-9H-purin-6-yl)-amine

Drug Info

[113]

162

Cyclohexyl-(9-ethyl-9H-purin-6-yl)-amine

Drug Info

[64]

163

Cyclohexyl-(9-methyl-9H-purin-6-yl)-amine

Drug Info

[64]

164

Cyclopentyl-(9-cyclopentyl-9H-purin-6-yl)-amine

Drug Info

[64]

165

Cyclopentyl-(9-ethyl-9H-purin-6-yl)-amine

Drug Info

[64]

166

Cyclopentyl-(9-methyl-9H-purin-6-yl)-amine

Drug Info

[64]

167

Cyclopentyl-(9-phenyl-9H-purin-6-yl)-amine

Drug Info

[64]

168

DEPX

Drug Info

[114]

169

Ethyl 5-benzoyl-4-phenylthiazol-2-ylcarbamate

Drug Info

[42]

170

FR-166124

Drug Info

[115]

171

GNF-PF-2224

Drug Info

[117], [118], [119], [120]

172

GNF-PF-2700

Drug Info

[84]

173

Hexanoic Acid (2,6-diphenylpyrimidin-4-yl)amide

Drug Info

[121]

174

Isoguanosine

Drug Info

[124]

175

Kuanoniamine D

Drug Info

[126]

176

L-249313

Drug Info

[47]

177

LUF-5417

Drug Info

[42]

178

LUF-5433

Drug Info

[42]

179

LUF-5735

Drug Info

[121]

180

LUF-5737

Drug Info

[121]

181

LUF-5764

Drug Info

[121]

182

LUF-5767

Drug Info

[121]

183

LUF-5816

Drug Info

[77]

184

LUF-5853

Drug Info

[78]

185

LUF-5956

Drug Info

[76]

186

LUF-5957

Drug Info

[76]

187

LUF-5962

Drug Info

[76]

188

LUF-5978

Drug Info

[77]

189

LUF-5980

Drug Info

[77]

190

LUF-5981

Drug Info

[77]

191

LUF-6258

Drug Info

[128]

192

N*6*-Cyclohexyl-N*2*-ethyl-9H-purine-2,6-diamine

Drug Info

[113]

193

N*6*-Cyclohexyl-N*2*-phenyl-9H-purine-2,6-diamine

Drug Info

[113]

194

N*6*-Cyclooctyl-N*2*-phenyl-9H-purine-2,6-diamine

Drug Info

[113]

195

N-(2,6-diphenylpyrimidin-4-yl)-2-ethylbutyramide

Drug Info

[121]

196

N-(2,6-diphenylpyrimidin-4-yl)-3-methylbutyramide

Drug Info

[121]

197

N-(2,6-diphenylpyrimidin-4-yl)acetamide

Drug Info

[121]

198

N-(2,6-diphenylpyrimidin-4-yl)benzamide

Drug Info

[121]

199

N-(2,6-diphenylpyrimidin-4-yl)butyramide

Drug Info

[121]

200

N-(2,6-diphenylpyrimidin-4-yl)isobutyramide

Drug Info

[121]

201

N-(2,6-diphenylpyrimidin-4-yl)propionamide

Drug Info

[121]

202

N-(2-(furan-2-yl)-3,4'-bipyridin-6-yl)acetamide

Drug Info

[133]

203

N-(4,5-diphenylpyrimidin-2-yl)acetamide

Drug Info

[121]

204

N-(4,6-diphenylpyrimidin-2-yl)-2-ethylbutyramide

Drug Info

[121]

205

N-(4,6-diphenylpyrimidin-2-yl)-3-chlorobenzamide

Drug Info

[121]

206

N-(4,6-diphenylpyrimidin-2-yl)-3-methylbutyramide

Drug Info

[121]

207

N-(4,6-diphenylpyrimidin-2-yl)benzamide

Drug Info

[121]

208

N-(4,6-diphenylpyrimidin-2-yl)propionamide

Drug Info

[121]

209

N-(4-Phenyl-thiazol-2-yl)-benzamide

Drug Info

[74]

210

N-(5-Benzoyl-4-phenylthiazol-2-yl)benzamide

Drug Info

[42]

211

N6-((+/-)-endo-norborn-2-yl)adenosine

Drug Info

[75]

212

N6-CYCLOPENTYLADENOSINE

Drug Info

[73]

213

N6-methoxy-2-phenylethynyladenosine

Drug Info

[83]

214

N6-methoxy-2-[(2-pyridinyl)ethynyl]adenosine

Drug Info

[83]

215

N6-methoxy-2-[(3-pyridinyl)ethynyl]-adenosine

Drug Info

[83]

216

N6-methoxy-2-[(4-methoxyphenyl)ethynyl]adenosine

Drug Info

[83]

217

N6-methoxy-2-[(4-methylphenyl)ethynyl]adenosine

Drug Info

[83]

218

N6-methoxy-2-[(4-pentylphenyl)ethynyl]adenosine

Drug Info

[83]

219

N6-methoxy-2-[(4-pyridinyl)ethynyl]adenosine

Drug Info

[83]

220

N6-methoxy-2-[2-(trimethylsilyl)ethynyl]adenosine

Drug Info

[83]

221

N6-[(4-Amino)-phenyl]-9-benzyl-2-phenyladenine

Drug Info

[134]

222

N6-[(4-Nitro)-phenyl]-9-benzyl-2-phenyladenine

Drug Info

[134]

223

P-IODOAMPHETAMINE

Drug Info

[135]

224

PD-115199

Drug Info

[136]

225

PD-81723

Drug Info

[137]

226

Pentanoic acid (4,6-diphenylpyrimidin-2-yl)amide

Drug Info

[121]

227

Phenyl(2-(trifluoromethyl)quinolin-4-yl)methanol

Drug Info

[138]

228

Phenyl-(9-phenyl-9H-purin-6-yl)-amine

Drug Info

[64]

229

PSB-0788

Drug Info

[139]

230

PSB-1115

Drug Info

[139]

231

PSB-601

Drug Info

[139]

232

R-N6-(phenylisopropyl)adenosine

Drug Info

[142], [80]

233

SB-298

Drug Info

[139]

234

SCH-63390

Drug Info

[143]

235

ST-1535

Drug Info

[105]

236

VCP-28

Drug Info

[145]

237

VUF-8507

Drug Info

[146]

238

[3H]NECA

Drug Info

[151]

239

[3H]OSIP339391

Drug Info

[84]

Cell-based Target Expression Variations

Top

Cell-based Target Expression Variations

Cell-based Target Expression Variations Info

Different Human System Profiles of Target	Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target. A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020). Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues. The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021). Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function. Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006). Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database. The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017). Human Similarity Proteins Human Tissue Distribution Human Pathway Affiliation Biological Network Descriptors

Different Human System Profiles of Target

Top

Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.

A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).

Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.

The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).

Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.

Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).

Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.

The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).

Human Similarity Proteins

Human Tissue Distribution

Human Pathway Affiliation

Biological Network Descriptors

Protein Name	Pfam ID	Percentage of Identity (%)	E value
Olfactory receptor 1N1 (OR1N1)	PF13853	27.184 (56/206)	3.83E-12
Olfactory receptor 1A2 (OR1A2)	PF13853	26.738 (50/187)	4.32E-10
Olfactory receptor 1G1 (OR1G1)	PF13853	21.498 (66/307)	4.49E-10
Olfactory receptor 10A6 (OR10A6)	PF13853	25.121 (52/207)	6.47E-10
Olfactory receptor 10G7 (OR10G7)	PF13853	23.881 (32/134)	1.58E-09
Olfactory receptor 1P1 (OR1P1)	PF13853	24.731 (46/186)	2.42E-09
Olfactory receptor 7A17 (OR7A17)	PF13853	22.635 (67/296)	3.20E-09
Olfactory receptor 10G9 (OR10G9)	PF13853	19.620 (62/316)	9.41E-09
Olfactory receptor 10G4 (OR10G4)	PF13853	23.134 (31/134)	1.36E-08
Olfactory receptor 7G2 (OR7G2)	PF13853	32.381 (34/105)	4.00E-08
Olfactory receptor 4C16 (OR4C16)	PF13853	28.926 (35/121)	5.01E-08
Olfactory receptor 10G8 (OR10G8)	PF13853	22.388 (30/134)	6.86E-08
Olfactory receptor 1J1 (OR1J1)	PF13853	21.538 (28/130)	7.36E-08
Olfactory receptor 1D2 (OR1D2)	PF13853	29.268 (36/123)	8.33E-08
Olfactory receptor 1N2 (OR1N2)	PF13853	27.692 (36/130)	8.52E-08
Olfactory receptor 7C2 (OR7C2)	PF13853	26.316 (35/133)	1.39E-07
Olfactory receptor 7C1 (OR7C1)	PF13853	26.471 (36/136)	1.42E-07
Olfactory receptor 7A5 (OR7A5)	PF13853	26.190 (44/168)	1.42E-07
Olfactory receptor 7A10 (OR7A10)	PF13853	26.515 (35/132)	1.49E-07
Olfactory receptor 2T34 (OR2T34)	PF13853	26.277 (36/137)	1.76E-07
Olfactory receptor 2T4 (OR2T4)	PF13853	21.160 (62/293)	1.81E-07
Olfactory receptor 7E24 (OR7E24)	PF13853	28.369 (40/141)	1.87E-07
Olfactory receptor 7D2 (OR7D2)	PF13853	21.088 (62/294)	2.26E-07
Olfactory receptor 52E5 (OR52E5)	PF13853	27.027 (30/111)	2.99E-07
Olfactory receptor 52A1 (OR52A1)	PF13853	27.907 (36/129)	3.13E-07
Olfactory receptor 9A4 (OR9A4)	PF13853	26.772 (34/127)	3.30E-07
Olfactory receptor 6S1 (OR6S1)	PF13853	25.000 (37/148)	4.27E-07
Olfactory receptor 1E1 (OR1E1)	PF13853	25.641 (30/117)	4.58E-07
Olfactory receptor 5B17 (OR5B17)	PF13853	24.232 (71/293)	4.66E-07
Olfactory receptor 2T3 (OR2T3)	PF13853	22.491 (65/289)	4.77E-07
Olfactory receptor 2J2 (OR2J2)	PF13853	23.239 (66/284)	5.85E-07
Putative olfactory receptor 7A2 (OR7A2P)	PF13853	24.800 (31/125)	7.83E-07
Olfactory receptor 4C6 (OR4C6)	PF13853	25.000 (30/120)	8.62E-07
Olfactory receptor 2T29 (OR2T29)	PF13853	22.456 (64/285)	9.55E-07
Olfactory receptor 1B1 (OR1B1)	PF13853	22.917 (44/192)	9.65E-07
Olfactory receptor 2T5 (OR2T5)	PF13853	22.456 (64/285)	1.02E-06
Olfactory receptor 5D14 (OR5D14)	PF13853	23.179 (70/302)	1.05E-06
Olfactory receptor 1A1 (OR1A1)	PF13853	24.064 (45/187)	1.08E-06
Olfactory receptor 2T10 (OR2T10)	PF13853	27.338 (38/139)	1.11E-06
Olfactory receptor 52J3 (OR52J3)	PF13853	27.972 (40/143)	1.17E-06
Olfactory receptor 4K2 (OR4K2)	PF13853	24.031 (31/129)	1.22E-06
Olfactory receptor 9A2 (OR9A2)	PF13853	24.324 (36/148)	1.32E-06
Olfactory receptor 11L1 (OR11L1)	PF13853	21.886 (65/297)	1.37E-06
Olfactory receptor 11G2 (OR11G2)	PF13853	21.017 (62/295)	1.39E-06
Olfactory receptor 2A14 (OR2A14)	PF13853	25.833 (31/120)	1.45E-06
Olfactory receptor 5D13 (OR5D13)	PF13853	26.351 (39/148)	1.52E-06
Olfactory receptor 52I1 (OR52I1)	PF13853	28.283 (28/99)	1.68E-06
Olfactory receptor 52E8 (OR52E8)	PF13853	26.563 (34/128)	1.84E-06
Olfactory receptor 51E1 (OR51E1)	PF13853	29.204 (33/113)	1.93E-06
Olfactory receptor 1L1 (OR1L1)	PF13853	21.595 (65/301)	2.00E-06
Olfactory receptor 9A1 (OR9A1P)	PF13853	23.944 (51/213)	2.03E-06
Olfactory receptor 6N1 (OR6N1)	PF13853	29.323 (39/133)	2.04E-06
Olfactory receptor 10P1 (OR10P1)	PF13853	28.333 (34/120)	2.18E-06
Olfactory receptor 14J1 (OR14J1)	PF13853	24.590 (30/122)	2.45E-06
Olfactory receptor 2A12 (OR2A12)	PF13853	24.793 (30/121)	2.90E-06
Olfactory receptor 52I2 (OR52I2)	PF13853	25.962 (27/104)	3.25E-06
Olfactory receptor 4S1 (OR4S1)	PF13853	24.590 (30/122)	3.86E-06
Olfactory receptor 2AG2 (OR2AG2)	PF13853	20.863 (58/278)	4.10E-06
Olfactory receptor 11H4 (OR11H4)	PF13853	26.718 (35/131)	4.68E-06
Olfactory receptor 1D4 (OR1D4)	PF13853	29.412 (35/119)	6.86E-06
Olfactory receptor 6N2 (OR6N2)	PF13853	27.350 (32/117)	6.87E-06
Olfactory receptor 6M1 (OR6M1)	PF13853	22.764 (28/123)	6.91E-06
Olfactory receptor 1S1 (OR1S1)	PF13853	25.806 (32/124)	7.16E-06
Olfactory receptor 6F1 (OR6F1)	PF13853	24.818 (34/137)	7.37E-06
Olfactory receptor 4N5 (OR4N5)	PF13853	25.000 (30/120)	7.50E-06
Olfactory receptor 4F15 (OR4F15)	PF13853	21.053 (64/304)	8.94E-06
Olfactory receptor 52R1 (OR52R1)	PF13853	25.490 (26/102)	9.61E-06
Olfactory receptor 1J2 (OR1J2)	PF13853	21.379 (31/145)	1.04E-05
Olfactory receptor 7G3 (OR7G3)	PF13853	26.271 (31/118)	1.06E-05
Olfactory receptor 1D5 (OR1D5)	PF13853	29.412 (35/119)	1.20E-05
Olfactory receptor 2J1 (OR2J1)	PF13853	23.239 (66/284)	1.25E-05
Olfactory receptor 51I2 (OR51I2)	PF13853	27.966 (33/118)	1.35E-05
Olfactory receptor 10H4 (OR10H4)	PF13853	24.786 (29/117)	1.50E-05
Olfactory receptor 8U3 (OR8U3)	PF13853	26.667 (36/135)	1.55E-05
Olfactory receptor 12D3 (OR12D3)	PF13853	22.857 (32/140)	1.79E-05
Olfactory receptor 52H1 (OR52H1)	PF13853	28.378 (42/148)	1.81E-05
Olfactory receptor 52E4 (OR52E4)	PF13853	23.423 (26/111)	1.82E-05
Olfactory receptor 52Z1P (OR52Z1P)	PF13853	29.825 (34/114)	1.82E-05
Olfactory receptor 7G1 (OR7G1)	PF13853	29.412 (30/102)	1.95E-05
Olfactory receptor 10A3 (OR10A3)	PF13853	22.685 (49/216)	2.42E-05
Olfactory receptor 4Q3 (OR4Q3)	PF13853	26.496 (31/117)	2.48E-05
Olfactory receptor 52A5 (OR52A5)	PF13853	28.846 (30/104)	2.68E-05
Olfactory receptor 5AL1 (OR5AL1)	PF13853	26.027 (38/146)	2.71E-05
Putative olfactory receptor 1F12P (OR1F12P)	PF13853	24.576 (29/118)	2.73E-05
Olfactory receptor 13J1 (OR13J1)	PF13853	24.800 (31/125)	3.15E-05
Olfactory receptor 1J4 (OR1J4)	PF13853	25.758 (34/132)	3.16E-05
Olfactory receptor 52D1 (OR52D1)	PF13853	32.692 (34/104)	3.29E-05
Olfactory receptor 2J3 (OR2J3)	PF13853	24.648 (70/284)	3.50E-05
Olfactory receptor 11A1 (OR11A1)	PF13853	29.825 (34/114)	3.50E-05
Olfactory receptor 1L6 (OR1L6)	PF13853	21.608 (43/199)	3.93E-05
Olfactory receptor 5M10 (OR5M10)	PF13853	21.575 (63/292)	4.01E-05
Olfactory receptor 10AG1 (OR10AG1)	PF13853	22.759 (66/290)	4.25E-05
Olfactory receptor 4K15 (OR4K15)	PF13853	27.193 (31/114)	4.33E-05
Olfactory receptor 51H1 (OR51H1)	PF13853	26.852 (29/108)	4.92E-05
Olfactory receptor 6C2 (OR6C2)	PF13853	20.792 (42/202)	5.16E-05
Olfactory receptor 7D4 (OR7D4)	PF13853	22.901 (30/131)	5.16E-05
Olfactory receptor 4D9 (OR4D9)	PF13853	22.764 (28/123)	5.23E-05
Olfactory receptor 8H2 (OR8H2)	PF13853	25.191 (33/131)	5.49E-05
Olfactory receptor 1E2 (OR1E2)	PF13853	23.913 (33/138)	5.51E-05
Olfactory receptor 2A1/2A42 (OR2A1; OR2A42)	PF13853	26.724 (31/116)	5.87E-05
Olfactory receptor 10H1 (OR10H1)	PF13853	26.891 (32/119)	6.44E-05
Olfactory receptor 11H7 (OR11H7)	PF13853	21.212 (28/132)	6.61E-05
Olfactory receptor 8H1 (OR8H1)	PF13853	24.561 (28/114)	7.70E-05
Olfactory receptor 1S2 (OR1S2)	PF13853	21.622 (64/296)	8.89E-05
Olfactory receptor 4C11 (OR4C11)	PF13853	24.786 (29/117)	9.19E-05
Olfactory receptor 8D4 (OR8D4)	PF13853	24.167 (29/120)	9.29E-05
Olfactory receptor 6K3 (OR6K3)	PF13853	21.818 (60/275)	9.35E-05
Olfactory receptor 52M1 (OR52M1)	PF13853	31.132 (33/106)	9.45E-05
Olfactory receptor 4F3/4F16/4F29 (OR4F3; OR4F16; OR4F29)	PF13853	24.348 (28/115)	9.58E-05
Olfactory receptor 1F1 (OR1F1)	PF13853	27.119 (32/118)	9.84E-05
Putative olfactory receptor 14L1 (OR14L1P)	PF13853	19.863 (58/292)	1.01E-04
Olfactory receptor 6Q1 (OR6Q1)	PF13853	24.219 (31/128)	1.02E-04
Olfactory receptor 4A15 (OR4A15)	PF13853	23.810 (30/126)	1.03E-04
Olfactory receptor 4K5 (OR4K5)	PF13853	21.262 (64/301)	1.07E-04
Olfactory receptor 10C1 (OR10C1)	PF13853	23.188 (32/138)	1.08E-04
Olfactory receptor 5M1 (OR5M1)	PF13853	21.233 (62/292)	1.33E-04
Olfactory receptor 8H3 (OR8H3)	PF13853	26.515 (35/132)	1.36E-04
Olfactory receptor 1L4 (OR1L4)	PF13853	21.106 (42/199)	1.47E-04
Olfactory receptor 51A7 (OR51A7)	PF13853	25.439 (29/114)	1.47E-04
Olfactory receptor 6C65 (OR6C65)	PF13853	27.200 (34/125)	1.50E-04
Olfactory receptor 2AT4 (OR2AT4)	PF13853	22.464 (31/138)	1.57E-04
Olfactory receptor 1M1 (OR1M1)	PF13853	24.000 (30/125)	1.64E-04
Olfactory receptor 13H1 (OR13H1)	PF13853	24.242 (32/132)	1.65E-04
Olfactory receptor 4F21 (OR4F21)	PF13853	23.478 (27/115)	1.75E-04
Olfactory receptor 52K1 (OR52K1)	PF13853	29.508 (36/122)	1.79E-04
Olfactory receptor 52B2 (OR52B2)	PF13853	28.571 (38/133)	2.26E-04
Olfactory receptor 52A4 (OR52A4P)	PF13853	25.000 (28/112)	2.34E-04
Olfactory receptor 2D2 (OR2D2)	PF13853	28.455 (35/123)	2.61E-04
Olfactory receptor 51G2 (OR51G2)	PF13853	26.415 (28/106)	2.63E-04
Olfactory receptor 4D5 (OR4D5)	PF13853	23.140 (28/121)	2.82E-04
Olfactory receptor 6A2 (OR6A2)	PF13853	23.077 (30/130)	2.88E-04
Olfactory receptor 8J2 (OR8J2)	PF13853	26.230 (32/122)	2.98E-04
Olfactory receptor 10V1 (OR10V1)	PF13853	23.529 (32/136)	3.05E-04
Olfactory receptor 5P3 (OR5P3)	PF13853	24.762 (26/105)	3.29E-04
Olfactory receptor 10H2 (OR10H2)	PF13853	26.891 (32/119)	3.32E-04
Olfactory receptor 5V1 (OR5V1)	PF13853	22.794 (31/136)	3.37E-04
Olfactory receptor 1I1 (OR1I1)	PF13853	26.667 (32/120)	3.94E-04
Olfactory receptor 4N4C (OR4N4C)	PF13853	21.284 (63/296)	4.09E-04
Olfactory receptor 2C1 (OR2C1)	PF13853	25.833 (31/120)	4.12E-04
Olfactory receptor 5M11 (OR5M11)	PF13853	27.344 (35/128)	4.39E-04
Olfactory receptor 4N2 (OR4N2)	PF13853	22.549 (69/306)	4.45E-04
Olfactory receptor 4M1 (OR4M1)	PF13853	21.154 (66/312)	4.52E-04
Olfactory receptor 1L3 (OR1L3)	PF13853	20.915 (64/306)	4.64E-04
Olfactory receptor 2G6 (OR2G6)	PF13853	26.230 (32/122)	4.89E-04
Olfactory receptor 6K6 (OR6K6)	PF13853	26.543 (43/162)	5.41E-04
Olfactory receptor 1L8 (OR1L8)	PF13853	25.000 (29/116)	6.69E-04
Olfactory receptor 8J3 (OR8J3)	PF13853	26.718 (35/131)	6.73E-04
Olfactory receptor 13A1 (OR13A1)	PF13853	24.561 (28/114)	6.93E-04
Olfactory receptor 51D1 (OR51D1)	PF13853	27.835 (27/97)	6.99E-04
Olfactory receptor 14A16 (OR14A16)	PF13853	20.906 (60/287)	7.52E-04
Putative olfactory receptor 52L2 (OR52L2P)	PF13853	27.027 (30/111)	1.00E-03
Olfactory receptor 4N4 (OR4N4)	PF13853	20.946 (62/296)	1.00E-03
Olfactory receptor 52E2 (OR52E2)	PF13853	25.410 (31/122)	1.00E-03
Olfactory receptor 10G3 (OR10G3)	PF13853	26.119 (35/134)	1.00E-03
Olfactory receptor 51E2 (OR51E2)	PF13853	28.431 (29/102)	1.00E-03
Olfactory receptor 51F1 (OR51F1)	PF13853	25.000 (26/104)	1.00E-03
Olfactory receptor 13C8 (OR13C8)	PF13853	22.807 (26/114)	1.00E-03
Olfactory receptor 14I1 (OR14I1)	PF13853	25.000 (34/136)	1.00E-03
Olfactory receptor 4C12 (OR4C12)	PF13853	21.849 (26/119)	1.00E-03
Olfactory receptor 10A4 (OR10A4)	PF13853	24.812 (33/133)	1.00E-03
Olfactory receptor 2A25 (OR2A25)	PF13853	23.622 (30/127)	1.00E-03
Olfactory receptor 2B11 (OR2B11)	PF13853	22.837 (66/289)	2.00E-03
Olfactory receptor 52N2 (OR52N2)	PF13853	26.016 (32/123)	2.00E-03
Olfactory receptor 10H3 (OR10H3)	PF13853	22.936 (25/109)	2.00E-03
Olfactory receptor 2H2 (OR2H2)	PF13853	25.833 (31/120)	2.00E-03
Olfactory receptor 6C3 (OR6C3)	PF13853	19.244 (56/291)	2.00E-03
Olfactory receptor 10J3 (OR10J3)	PF13853	23.664 (31/131)	2.00E-03
Olfactory receptor 4D10 (OR4D10)	PF13853	21.053 (24/114)	2.00E-03
Olfactory receptor 51V1 (OR51V1)	PF13853	28.000 (28/100)	2.00E-03
Olfactory receptor 52N4 (OR52N4)	PF13853	27.586 (32/116)	2.00E-03
Olfactory receptor 2M3 (OR2M3)	PF13853	20.000 (58/290)	2.00E-03
Olfactory receptor 8K5 (OR8K5)	PF13853	25.000 (31/124)	2.00E-03
Olfactory receptor 2AJ1 (OR2AJ1)	PF13853	22.069 (64/290)	2.00E-03
Olfactory receptor 10Q1 (OR10Q1)	PF13853	23.276 (27/116)	2.00E-03
Olfactory receptor 4K1 (OR4K1)	PF13853	22.481 (29/129)	2.00E-03
Olfactory receptor 1C1 (OR1C1)	PF13853	25.203 (31/123)	3.00E-03
Olfactory receptor 6K2 (OR6K2)	PF13853	25.000 (33/132)	3.00E-03
Olfactory receptor 51B2 (OR51B2)	PF13853	25.439 (29/114)	3.00E-03
Olfactory receptor 2H1 (OR2H1)	PF13853	26.829 (33/123)	3.00E-03
Olfactory receptor 4K13 (OR4K13)	PF13853	22.963 (31/135)	3.00E-03
Olfactory receptor 2A2 (OR2A2)	PF13853	22.314 (27/121)	3.00E-03
Olfactory receptor 6C1 (OR6C1)	PF13853	19.549 (26/133)	3.00E-03
Olfactory receptor 8U1 (OR8U1)	PF13853	26.400 (33/125)	3.00E-03
Olfactory receptor 6C74 (OR6C74)	PF13853	19.200 (24/125)	3.00E-03
Olfactory receptor 9Q1 (OR9Q1)	PF13853	26.772 (34/127)	4.00E-03
Olfactory receptor 2B6 (OR2B6)	PF13853	22.222 (26/117)	4.00E-03
Olfactory receptor 8U8 (OR8U8)	PF13853	26.400 (33/125)	4.00E-03
Olfactory receptor 5AP2 (OR5AP2)	PF13853	25.874 (37/143)	4.00E-03
Olfactory receptor 4K3 (OR4K3)	PF13853	24.167 (29/120)	4.00E-03
Olfactory receptor 2W1 (OR2W1)	PF13853	21.683 (67/309)	4.00E-03
Olfactory receptor 10A5 (OR10A5)	PF13853	23.577 (29/123)	4.00E-03
Olfactory receptor 2L2 (OR2L2)	PF13853	23.333 (28/120)	5.00E-03
Olfactory receptor 13F1 (OR13F1)	PF13853	22.302 (31/139)	5.00E-03
Olfactory receptor 1Q1 (OR1Q1)	PF13853	24.806 (32/129)	5.00E-03
Putative olfactory receptor 1F2 (OR1F2P)	PF13853	25.000 (29/116)	5.00E-03
Olfactory receptor 4K17 (OR4K17)	PF13853	18.667 (56/300)	5.00E-03
Olfactory receptor 52B4 (OR52B4)	PF13853	27.731 (33/119)	5.00E-03
Olfactory receptor 10W1 (OR10W1)	PF13853	24.348 (28/115)	5.00E-03
Putative olfactory receptor 10D3 (OR10D3)	PF13853	24.107 (27/112)	5.00E-03
Olfactory receptor 8K3 (OR8K3)	PF13853	24.615 (32/130)	5.00E-03
Click to Show/Hide the Information of Human Similarity Proteins


Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.

KEGG Pathway	Pathway ID	Affiliated Target
cGMP-PKG signaling pathway	hsa04022	Affiliated Target
Class: Environmental Information Processing => Signal transduction	Pathway Hierarchy
cAMP signaling pathway	hsa04024	Affiliated Target
Class: Environmental Information Processing => Signal transduction	Pathway Hierarchy
Sphingolipid signaling pathway	hsa04071	Affiliated Target
Class: Environmental Information Processing => Signal transduction	Pathway Hierarchy
Neuroactive ligand-receptor interaction	hsa04080	Affiliated Target
Class: Environmental Information Processing => Signaling molecules and interaction	Pathway Hierarchy
Regulation of lipolysis in adipocytes	hsa04923	Affiliated Target
Class: Organismal Systems => Endocrine system	Pathway Hierarchy
Renin secretion	hsa04924	Affiliated Target
Class: Organismal Systems => Endocrine system	Pathway Hierarchy
Click to Show/Hide the Information of Affiliated Human Pathways

Degree	1	Degree centrality	1.07E-04	Betweenness centrality	0.00E+00
Closeness centrality	1.84E-01	Radiality	1.31E+01	Clustering coefficient	0.00E+00
Neighborhood connectivity	1.60E+01	Topological coefficient	1.00E+00	Eccentricity	12
Download	Click to Download the Full PPI Network of This Target

Chemical Structure based Activity Landscape of Target

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Drug Property Profile of Target

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(1) Molecular Weight (mw) based Drug Clustering

(2) Octanol/Water Partition Coefficient (xlogp) based Drug Clustering

(3) Hydrogen Bond Donor Count (hbonddonor) based Drug Clustering

(4) Hydrogen Bond Acceptor Count (hbondacc) based Drug Clustering

(5) Rotatable Bond Count (rotbonds) based Drug Clustering

(6) Topological Polar Surface Area (polararea) based Drug Clustering

"RO5" indicates the cutoff set by lipinski's rule of five; "D123AB" colored in GREEN denotes the no violation of any cutoff in lipinski's rule of five; "D123AB" colored in PURPLE refers to the violation of only one cutoff in lipinski's rule of five; "D123AB" colored in BLACK represents the violation of more than one cutoffs in lipinski's rule of five

Co-Targets

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Co-Targets

Co-Targets Info

Target Poor or Non Binders

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Target Poor or Non Binders

Target Poor or Non Binders Info

Target Profiles in Patients

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Target Expression
Profile (TEP)

Target Expression Profile Info

Target Affiliated Biological Pathways

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KEGG Pathway

[+] 5 KEGG Pathways

cGMP-PKG signaling pathway

cAMP signaling pathway

Sphingolipid signaling pathway

Neuroactive ligand-receptor interaction

Morphine addiction

NetPath Pathway

[+] 2 NetPath Pathways

TCR Signaling Pathway

RANKL Signaling Pathway

Panther Pathway

[+] 2 Panther Pathways

Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway

Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

Reactome

[+] 2 Reactome Pathways

Adenosine P1 receptors

G alpha (i) signalling events

WikiPathways

[+] 4 WikiPathways

Nucleotide GPCRs

GPCRs, Class A Rhodopsin-like

GPCR ligand binding

GPCR downstream signaling

Target-Related Models and Studies

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Target Validation

Target Validation Info

Target QSAR Model

References

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