Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0L8DZ
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| Former ID |
DNC011633
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| Drug Name |
8-Phenyl-3,7-dihydro-purine-2,6-dione
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| Synonyms |
8-Phenylxanthine; 2879-14-3; UNII-0S2BVG6C31; CHEMBL285191; 0S2BVG6C31; 1H-Purine-2,6-dione, 3,9-dihydro-8-phenyl-; 1H-Purine-2,6-dione, 3,7-dihydro-8-phenyl-; Xanthine, 8-phenyl-; 8-Phenyl-3,7-dihydro-purine-2,6-dione; SCHEMBL378879; CTK0J1822; DTXSID50485464; BDBM50042214; ZINC13472986; 8-Phenyl-1H-purine-2,6(3H,7H)-dione
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C11H8N4O2
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| Canonical SMILES |
C1=CC=C(C=C1)C2=NC3=C(N2)C(=O)NC(=O)N3
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| InChI |
1S/C11H8N4O2/c16-10-7-9(14-11(17)15-10)13-8(12-7)6-4-2-1-3-5-6/h1-5H,(H3,12,13,14,15,16,17)
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| InChIKey |
ACCCXSZCOGNLFL-UHFFFAOYSA-N
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| CAS Number |
CAS 2879-14-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adenosine A1 receptor (ADORA1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | cGMP-PKG signaling pathway | |||
| cAMP signaling pathway | ||||
| Sphingolipid signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Morphine addiction | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| RANKL Signaling Pathway | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Reactome | Adenosine P1 receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Nucleotide GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationshi... J Med Chem. 1993 Oct 29;36(22):3341-9. | |||
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