Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0UM4R
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| Former ID |
DNC012199
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| Drug Name |
(2-Chloro-9-methyl-9H-purin-6-yl)-phenyl-amine
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| Synonyms |
CHEMBL98779; (2-Chloro-9-methyl-9H-purin-6-yl)-phenyl-amine; 2-chloro-9-methyl-N6-phenyladenine; 135394-17-1; SCHEMBL183230; DBTWDYPKBBODMU-UHFFFAOYSA-N; BDBM50009679; 2-Chloro-9-methyl-N-phenyl-9H-purin-6-amine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C12H10ClN5
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| Canonical SMILES |
CN1C=NC2=C(N=C(N=C21)Cl)NC3=CC=CC=C3
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| InChI |
1S/C12H10ClN5/c1-18-7-14-9-10(16-12(13)17-11(9)18)15-8-5-3-2-4-6-8/h2-7H,1H3,(H,15,16,17)
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| InChIKey |
DBTWDYPKBBODMU-UHFFFAOYSA-N
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| CAS Number |
CAS 135394-17-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adenosine A1 receptor (ADORA1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | cGMP-PKG signaling pathway | |||
| cAMP signaling pathway | ||||
| Sphingolipid signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Morphine addiction | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| RANKL Signaling Pathway | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Reactome | Adenosine P1 receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Nucleotide GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor. J Med Chem. 1991 Sep;34(9):2877-82. | |||
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