Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0K0OT
|
|||
| Former ID |
DNC003816
|
|||
| Drug Name |
GNF-PF-2224
|
|||
| Synonyms |
8-Cyclopentyl-1,3-dipropylxanthine; DPCPX; 102146-07-6; 8-cyclopentyl-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione; 1,3-Dpcpx; 1,3-dipropyl-8-cyclopentylxanthine; PD-116,948; PD-116948; UNII-9PTP4FOI9E; dipropylcyclopentylxanthine; 9PTP4FOI9E; CHEMBL183; MLS000069347; CHEBI:73282; 8-Cyclopentyl-3,7-dihydro-1,3-dipropyl-1H-purin-2,6-dione; 8-cyclopentyl-1,3-dipropyl-7H-purine-2,6-dione; 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX]; SMR000058434; DPCPX, 1,3-Dipropyl-8-cyclopentylxanthine
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2], [3], [4] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C16H24N4O2
|
|||
| Canonical SMILES |
CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3CCCC3
|
|||
| InChI |
1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)
|
|||
| InChIKey |
FFBDFADSZUINTG-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 102146-07-6
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
586298, 855876, 6679288, 7422377, 7978611, 8150148, 8151091, 11110874, 11113351, 11335352, 11360591, 11363165, 11365727, 11368289, 11372005, 11374834, 11376451, 11461563, 11485531, 11489624, 11490888, 11493042, 11494085, 12014525, 14776308, 14898584, 17404944, 24277697, 24439671, 26613161, 26680127, 26747024, 26751544, 47216654, 47216983, 47216984, 47515529, 47588863, 47589184, 47810974, 47885280, 48110328, 49689246, 49689262, 50027500, 50100192, 50104134, 50104135, 53777487, 53787841
|
|||
| ChEBI ID |
CHEBI:73282
|
|||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil. J Invest Dermatol. 2001 Dec;117(6):1594-600. | |||
| REF 2 | Influence of the antagonist of adenosine A1 receptors, 8-cyclopentyl-1 ,3-dipropylxanthine, upon the anticonvulsant activity of antiepileptic drugs in mice. Przegl Lek. 2008;65(11):759-63. | |||
| REF 3 | Potent adenosine receptor antagonists that are selective for the A1 receptor subtype. Mol Pharmacol. 1987 Mar;31(3):247-52. | |||
| REF 4 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 386). | |||
| REF 5 | Synthesis and theoretical studies on energetics of novel N- and O- perfluoroalkyl triazole tagged thienopyrimidines--their potential as adenosine r... Eur J Med Chem. 2010 May;45(5):1739-45. | |||
| REF 6 | Discovery of FK453, a novel non-xanthine adenosine A1 receptor antagonist, Bioorg. Med. Chem. Lett. 6(17):2059-2062 (1996). | |||
| REF 7 | Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A(1) adenosine receptor ligands. Bioorg Med Chem. 2010 Nov 15;18(22):7890-9. | |||
| REF 8 | Adenosine receptor ligands: differences with acute versus chronic treatment. Trends Pharmacol Sci. 1996 Mar;17(3):108-13. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.