Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92072 | Target Info | |||
| Target Name | Adenosine A1 receptor (ADORA1) | ||||
| Synonyms |
Adenosine receptor A1; A(1) adenosine receptor
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|
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| Target Type | Successful Target | ||||
| Gene Name | ADORA1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 128 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(S)-DHPA
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|
Investigative | Compound Info | ||
| Synonyms |
S-Dihydroxypropyladenine; (S)-9-(2,3-Dihydroxypropyl)adenine; (S)-DHPA; 9-D-(2,3-Dihydroxypropyl)adenine; 54262-83-8; BRN 0990757; (2s)-3-(6-amino-9h-purin-9-yl)propane-1,2-diol; (2S)-3-(6-aminopurin-9-yl)propane-1,2-diol; (S)-3-(6-Amino-9H-purin-9-yl)-1,2-propanediol; 1,2-Propanediol, 3-(6-amino-9H-purin-9-yl)-, (S)-; 9-(S)-(2,3-Dihydroxypropyl)adenine; AC1Q4VGK; DHPA, (S)-DHPA; AC1L2JB5; 5-26-16-00201 (Beilstein Handbook Reference); SCHEMBL936286; CHEMBL494759; CTK5A0230; 9-(1,2-dihydroxypropyl)adenine; ZINC370772
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|
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
8-Hydroxy-5,7,9-trimethyl-delta-carboline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL458947; 8-Hydroxy-5,7,9-trimethyl-delta-carboline
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| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
9-Butyl-9H-adenine
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Investigative | Compound Info | ||
| Synonyms |
2715-70-0; 9-butyl-9H-purin-6-ylamine; 9H-Purin-6-amine, 9-butyl-; 9-Butyl-9H-purin-6-amine; 9H-Purin-6-amine, 9-butyl- (9CI); CHEMBL449628; 9-Butyl-9H-adenine; 9-butylpurin-6-amine; 9-butyladenine; NSC19094; NSC 19094; Adenine, 9-butyl-; AC1L2PTM; AC1Q4VHO; 9H-Purin-6-amine,9-butyl-; SCHEMBL1074972; CTK4F9171; DTXSID10181617; MolPort-011-342-029; BKXMJMZKKNIYRD-UHFFFAOYSA-N; ZINC1562338; NSC-19094; BDBM50256951; AKOS012922662; MCULE-9977877843; 9-Butyl-9H-purin-6-amine, AldrichCPR
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|
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
7-Propyl-7H-adenine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL449108; 7-Propyl-7H-adenine; 7H-Purin-6-amine, 7-propyl-; BDBM50256892
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
9-(3-Hydroxypropyl)-9H-adenine
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Investigative | Compound Info | ||
| Synonyms |
711-64-8; 9H-Purine-9-propanol, 6-amino-; CHEMBL445974; 9-(3-Hydroxypropyl)-9H-adenine; 3-(6-Amino-9H-purin-9-yl)propan-1-ol; 9-(3-Hydroxypropyl)adenine; Oprea1_108729; 9-(3'-hydroxypropyl)adenine; SCHEMBL1635576; CTK2H3970; DTXSID10500041; MolPort-014-160-140; ZINC5391161; BDBM50257052; 3-(6-aminopurin-9-yl)propan-1-ol; AKOS010941287; 3-(6-Amino-9H-purine-9-yl)-1-propanol
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
9-Phenylethyl-9H-adenine
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Investigative | Compound Info | ||
| Synonyms |
9-Phenethyladenine; CHEMBL445696; 7051-86-7; 9-Phenylethyl-9H-adenine; NSC211638; AC1L7EWL; Maybridge3_003004; 9-phenethylpurin-6-amine; 9-(2-phenylethyl)adenine; MLS001181918; SCHEMBL1230786; 6-Amino-9-phenethyl-9H-purine; DTXSID10309298; MolPort-002-902-800; ZINC158322; HMS1439I12; HMS2852H03; BDBM50257097; CCG-51741; AKOS012923591; NSC-211638; MCULE-7488166280; IDI1_014391; SMR000567667
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
9-But-3-enyl-9H-adenine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL510907; 9-But-3-enyl-9H-adenine; BDBM50256954
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|
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
8-Hydroxy-7,9-dimethyl-delta-carboline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL458465; 8-Hydroxy-7,9-dimethyl-delta-carboline
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| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
DAMGO
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Investigative | Compound Info | ||
| Synonyms |
DAMGO; DAGO; glyol; Dagol; DAMGE; 78123-71-4; 2-Ala-4-mephe-5-gly-enkephalin; Tyr-ala-gly-(nme)phe-gly-ol; Enkephalin, ala(2)-mephe(4)-gly(5)-; RX 783006; (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; Ala(2)-mephe(4)-gly-ol(5) enkephalin; CHEBI:272; CHEMBL38874; Tyr-D-Ala-Gly-MePhe-Gly-ol; Enkephalin, Ala(2)-MePhe(4)-Gly-ol(5)-; H-Tyr-D-Ala-Gly-N-Me-Phe-Glycinol; Enkephalin, alanyl(2)-methylphenylalanyl(4)-glycine(5)-; [3H]DAMGO; L-Phenylalaninamide, L-tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-Nalpha-methyl-
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| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
6-Hydroxy-5,7-dimethyl-beta-carboline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL458558; 6-Hydroxy-5,7-dimethyl-beta-carboline
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| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
9-Cyclopropyl-9H-adenine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL469409; 9-Cyclopropyl-9H-adenine; 9-cyclopropylpurin-6-amine; AC1L987W
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
9-BENZYL-9H-ADENINE
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Investigative | Compound Info | ||
| Synonyms |
9-Benzyladenine; 4261-14-7; 9-benzyl-9H-purin-6-amine; N9-Benzyladenine; 9-Benzylaminopurine; ADENINE, 9-BENZYL-; 9-Bap; 9-Benzyl-6-aminopurine; N(sup 9)-Benzyladenine; 9-BENZYL-9H-ADENINE; 9-Benzyl-9H-purin-6-ylamine; 9H-Purin-6-amine, 9-(phenylmethyl)-; CCRIS 6908; SQ 21611; 9-benzylpurin-6-amine; NSC 35649; 9-(Phenylmethyl)-9H-purin-6-amine; CHEMBL266094; 9H-Purin-6-amine,9-(phenylmethyl)-; AC1L2FWA; MLS000660735; SCHEMBL104932; 9-Benzyl-9H-purine-6-amine; CTK4I6467; DTXSID70195371; MRHCSNNEUHXNIC-UHFFFAOYSA-N; HMS2676M21
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
9-Cycloheptyl-9H-adenine
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Investigative | Compound Info | ||
| Synonyms |
9-cycloheptylpurin-6-amine; 9-cycloheptyl-9h-purin-6-amine; CHEMBL62835; 6961-60-0; 9-Cycloheptyl-9H-adenine; NSC62733; AC1L6KRZ; AC1Q4VH9; CTK5D0614; DTXSID20289678; 6-Amino-9-cycloheptyl-9H-purine; 9-Cycloheptyl-9H-purin-6-ylamine; 9H-Purin-6-amine, 9-cycloheptyl-; BDBM50013702; NSC-62733
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
ALLOXAZINE
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Investigative | Compound Info | ||
| Synonyms |
Alloxazine; Isoalloxazine; 490-59-5; Alloxazin; benzo[g]pteridine-2,4(1H,3H)-dione; 1H-Benzo[g]pteridine-2,4-dione; Benzo(g)pteridine-2,4(1H,3H)-dione; UNII-880W3VF9YW; benzo[g]pteridine-2,4(3H,10H)-dione; CHEMBL68500; 880W3VF9YW; CHEBI:37325; HAUGRYOERYOXHX-UHFFFAOYSA-N; Benzo[g]pteridine-2,4[1H,3H]-dione; 1H,2H,3H,4H-benzo[g]pteridine-2,4-dione; Benzo[g]pteridine-2,3H)-dione; WLN: T C666 BN DMVMV INJ; 1,3-dihydrobenzo[g]pteridine-2,4-dione; SR-01000075199; Alloxazine, 96%; EINECS 207-714-3; NSC 203056; AC1NSYUA; Lopac-A-242
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| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
6-Methoxy-4H-indeno[1,2-d][1,3]thiazol-2-amine;hydroiodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL288169; SCHEMBL3994593
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|
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| Activity |
EC50 = 50000 nM
|
[5] | |||
| Compound Name |
2-[(4-Acetylphenyl)ethynyl]-N6-methoxy-5''-N-methylcarboxamidoadenosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL223625; BDBM50205714
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| Activity |
Ki = 53800 nM
|
[6] | |||
| Compound Name |
(2S,3S,4R,5R)-3,4-Dihydroxy-5-(6-(methoxyamino)-2-((4-methoxyphenyl)ethynyl)-9H-purin-9-yl)-N-methyltetrahydrofuran-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL573950; BDBM50299700
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| Activity |
Ki = 53800 nM
|
[7] | |||
| Compound Name |
Chembl4167197
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Investigative | Compound Info | ||
| Synonyms |
BDBM50369693
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| Activity |
Ki = 54000 nM
|
[8] | |||
| Compound Name |
2-(3-Furyl)-6-ethylthieno[2,3-d]pyrimidine-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3745803; BDBM50500485; AKOS033073651; MCULE-9749057173; J3.552.314F
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| Activity |
Ki = 56234.13 nM
|
[9] | |||
| Compound Name |
N-Benzoyl-N-(4-chloro-2-methylpyrazolo[3,4-d]pyrimidin-6-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3114159; BDBM50495624
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| Activity |
Ki ~ 60000 nM
|
[10] | |||
| Compound Name |
N-[4-Chloro-2-(2-phenylethyl)pyrazolo[3,4-d]pyrimidin-6-yl]-4-(trifluoromethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3114157; BDBM50495612
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| Activity |
Ki ~ 60000 nM
|
[10] | |||
| Compound Name |
2-Cyclopropyl-6-ethyl-3H,4H-thieno[2,3-d]pyrimidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3746858; BDBM50500491; ZINC48860610; AKOS034588204; MCULE-6635982465; Z790344744
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| Activity |
Ki = 61659.5 nM
|
[9] | |||
| Compound Name |
6-Ethylthieno[2,3-d]pyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
6-ethylthieno[2,3-d]pyrimidin-4-ol; 6-ethyl-3H-thieno[2,3-d]pyrimidin-4-one; 6-Ethyl-thieno[2,3-d]pyrimidin-4-ol; CHEMBL6215; MLS000029626; 6-ethyl-3H,4H-thieno[2,3-d]pyrimidin-4-one; SMR000009585; 6-ethylthiopheno[2,3-d]pyrimidin-4-ol; Maybridge3_001404; ChemDiv2_002305; Cambridge id 5313227; cid_645569; SCHEMBL3108511; SCHEMBL10325022; BDBM37871; CTK8C0316; DTXSID90349410; HMS1375I17; HMS1434P18; HMS1673P03; HMS2289E05; ALBB-019867; ANW-64489; BDBM50500488; MFCD00457520; QC-140; SBB014493; STK674212; STK827908; ZINC18193916; AKOS000265733; AKOS000541118; 6-ethyl thieno[2,3-d]pyrimidin-4-ol; MCULE-8942412555; IDI1_012791; AS-64355; DB-065548; ST4037528; FT-0741237; Z2902; 4-Oxo-(3H)-6-ethylthieno[2,3-d]pyrimidine; C-1220; thieno[2,3-d]pyrimidin-4(3H)-one, 6-ethyl-; SR-01000519447; 6-Ethyl-3,4-dihydrothieno[2,3-d]pyrimidine-4-one; SR-01000519447-1; Z94601204
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| Activity |
Ki = 75857.76 nM
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[9] | |||
| Compound Name |
6-Amino-2-(2,2-dimethylpropyl)pyrazolo[3,4-d]pyrimidine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410296; BDBM50072918
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| Activity |
Ki ~ 90000 nM
|
[11] | |||
| Compound Name |
2-N-(4-Chlorophenyl)-7-N,7-N-dimethyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3088350; BDBM50189065
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| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
1-(4-Methoxyphenyl)-3-[11-methyl-4-(4-phenylphenyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1834696; BDBM50355155
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| Activity |
Ki ~ 100000 nM
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[13] | |||
| Compound Name |
7-(2-Hydroxypropyl)-7H-adenine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL475456; 1-(6-aminopurin-7-yl)propan-2-ol; BDBM50257056
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
7-N,7-N-Dimethyl-2-N-phenyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3088342; BDBM50189100
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| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
Ethyl 6-(dibenzoylamino)-2-methylpyrazolo[3,4-d]pyrimidine-4-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410317; BDBM50072929
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| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
(2-Oxo-3-thiophen-3-ylchromen-8-yl) acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3819209
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| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
7-N-Benzyl-2-(furan-2-yl)-5-N-propan-2-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3754718; BDBM50137632
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| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
6-Hydroxy-5,7,9-trimethyl-beta-carboline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL458409; BDBM50251139
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| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
11-Methyl-4-(4-phenylphenyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1834621; BDBM50355163
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| Activity |
Ki ~ 100000 nM
|
[13] | |||
| Compound Name |
Ethyl 6-[bis(3,4-difluorobenzoyl)amino]-2-methylpyrazolo[3,4-d]pyrimidine-4-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410319; BDBM50072927
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| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
N-Benzoyl-N-[4-chloro-2-(2-phenylethyl)pyrazolo[3,4-d]pyrimidin-6-yl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3114162; BDBM50495623
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| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
2,5,7-Trimethyl-9H-pyrido[3,4-b]indol-2-ium-6-ol;iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL541164
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| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4283491
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Investigative | Compound Info | ||
| Synonyms |
BDBM50470467
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| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
(2S,3R,4S)-2-(Hydroxymethyl)-5-[(8R)-5-imino-8-phenyl-8,9-dihydro-7H-imidazo[2,1-f]purin-3-yl]oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL609645; BDBM50366575
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| Activity |
EC50 = 100000 nM
|
[17] | |||
| Compound Name |
N-[4-Chloro-2-(2,2-dimethylpropyl)pyrazolo[3,4-d]pyrimidin-6-yl]-4-(trifluoromethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3114153; BDBM50495614
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| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-Amino-8-(2-phenylethynyl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3350497; 8-phenylethynyladenosine; 8-(phenylethynyl)adenosine; CHEMBL611516; SCHEMBL4378434; BDBM50366687
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| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-4-(dimethylamino)-2-(4-methylanilino)-1,3-thiazole-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3403732; BDBM50064624
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| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
Chembl4276937
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Investigative | Compound Info | ||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
11-Methyl-4-[4-(trifluoromethyl)phenyl]-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1834573; BDBM50355162
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| Activity |
Ki ~ 100000 nM
|
[13] | |||
| Compound Name |
N-Benzyl-2-(furan-2-yl)-5-phenoxy-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752965; BDBM50137532
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| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
2-(Furan-2-yl)-5-(methylamino)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314915; BDBM50048033
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| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
7-Chloro-N-(3,4,5-trimethoxyphenyl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827097; BDBM50189066
Click to Show/Hide
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| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
Ethyl 6-(dibenzoylamino)-2-(2-phenylethyl)pyrazolo[3,4-d]pyrimidine-4-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410321; BDBM50072925
Click to Show/Hide
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| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
N-(4-Chlorophenyl)-7-pyrrolidin-1-yl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3088334; BDBM50189052
Click to Show/Hide
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| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
Ethyl 2-[[2-(acetyloxyamino)-4-(dimethylamino)-1,3-thiazole-5-carbonyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3403730; BDBM50064622
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
N-(3-Bromophenyl)-7-pyrrolidin-1-yl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827889; BDBM50189104
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
(2-Oxo-3-thiophen-2-ylchromen-8-yl) acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3818444
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
8-Bromo-9-cycloheptyl-9H-adenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL474396; BDBM50257003
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
Ethyl 6-[bis(4-bromobenzoyl)amino]-2-methylpyrazolo[3,4-d]pyrimidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410318; BDBM50072928
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
Phenyl(2-(trifluoromethyl)thieno[3,2-d]pyrimidin-4-yl)methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL265465; SCHEMBL6859453; BDBM50377462; phenyl-[2-(trifluoromethyl)thieno[3,2-d]pyrimidin-4-yl]methanol
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[22] | |||
| Compound Name |
1,3-Dimethyl-8-[4-methoxy-3-(2-morpholin-4-ylethoxy)-phenylxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL520031; BDBM50279444
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[23] | |||
| Compound Name |
5-[(4-Fluorophenyl)methylamino]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314926; BDBM50048055
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
N-(4-Chloro-2-methylpyrazolo[3,4-d]pyrimidin-6-yl)-4-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3114145; BDBM50495616
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
7-(4-Ethylpiperazin-1-yl)-N-phenyl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3088345; BDBM50189093
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
(8-Acetyloxy-2-oxo-3-thiophen-3-ylchromen-7-yl) acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3818301
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
7-Methyladenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-Methyl-7H-purin-6-amine; 6-Amino-7-methylpurine; N7-Methyladenine; 7H-Purin-6-amine, 7-methyl-; Adenine, 7-methyl-; 7-methylpurin-6-amine; 7H-Purin-6-amine, 7-methyl- (9CI); CHEMBL449346; MFCD00127790; NSC 7857; 7-Methyl-7H-adenine; 7-methyl-6-purinamine; 7-Methyladenine, 97%; 7-methylpurine-6-ylamine; 7-methyl-N7-Methyladenine; DSSTox_CID_29335; DSSTox_RID_83451; DSSTox_GSID_49376; SCHEMBL26976; Adenine, 7-methyl- (8CI); 7-Methyl-7H-purin-6-ylamine; DTXSID9049376; 7-Methyl-7H-purin-6-amine #; CTK5H2669; NSC7857; ZINC901320; KS-000018VI; NSC-7857; Tox21_202951; 5887AC; BDBM50240579; AKOS000320617; AKOS006378195; NCGC00260497-01; SY250877; TS-00058; N-ACETYL-DL-2-AMINO-N-BUTYRICACID; FT-0657514; ST50298865; 7-methyl-7H-purin-6-amine (ACD/Name 4.0); C02241; 7-methyl-7H-purin-6-ylamine (ACD/Name 4.0); 935M693; A844638; J-640190; J-800191; W-204088; 6-Amino-7-methylpurine, 7-Methyl-7H-purin-6-amine; Q27103966
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[5-(4-Amino-5,6-dimethylthieno[2,3-d]pyrimidin-2-yl)-4-phenyl-1,3-thiazol-2-yl]-4-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391845; BDBM50492061
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[24] | |||
| Compound Name |
5-(Cyclohexylcarbamoylamino)-2-(furan-2-yl)-N-(2-phenylethyl)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314881; BDBM50047984
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
Chembl4294838
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
N-(4-Chlorophenyl)-7-(4-methylpiperazin-1-yl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3088333; BDBM50189177
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
N-(4-Chlorophenyl)-7-morpholin-4-yl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3088347; BDBM50189095
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
1,3-Dimethyl-8-[3-methoxy-4-(2-morpholin-4-ylethoxy)-phenylxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL520212; BDBM50279420
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[23] | |||
| Compound Name |
Ethyl 2-(furan-2-yl)-5-[(2-phenylacetyl)amino]-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314885; BDBM50047988
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
Ethyl 2-propan-2-yl-6-[[4-(trifluoromethyl)benzoyl]amino]pyrazolo[3,4-d]pyrimidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410308; BDBM50072941
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
Phenyl-[2-(trifluoromethyl)quinazolin-4-yl]methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL265464; BDBM50377457
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[22] | |||
| Compound Name |
Ethyl 6-[(4-fluorobenzoyl)amino]-2-methylpyrazolo[3,4-d]pyrimidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410303; BDBM50072936
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
N-(4-Chloro-2-methylpyrazolo[3,4-d]pyrimidin-6-yl)-4-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3114146; BDBM50495600
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
8-(1-Hexynyl)adenosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2181966; BDBM50397720; Adenosine, 8-(1-hexynyl)-; CHEMBL610640; BDBM50366688; (2R,3R,4S,5R)-2-(6-amino-8-hex-1-ynylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[25] | |||
| Compound Name |
1-(4-Fluorophenyl)-3-[11-methyl-4-(4-phenylphenyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1834629; BDBM50355151
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[13] | |||
| Compound Name |
N-(4-Chlorophenyl)-7-piperidin-1-yl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3088348; BDBM50189061
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
9H-Purin-6-amine, 9-(2-methylpropyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL503566; 9-Isobutyladenine; 9-Isobutyl-9H-adenine; SCHEMBL12620928; BDBM50256948; AKOS012922846
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
7-Isobutyl-7H-adenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472147; BDBM50256949
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
1,3-Dimethyl-8-[4-methoxy-3-(2-piperidin-1-ylethoxy)-phenyl]xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL485698; BDBM50279424
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[23] | |||
| Compound Name |
Chembl4294681
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50470475
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
5-(Cyclohexylcarbamoylamino)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314886; BDBM50047989
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
9-Cyclohexyladenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
9-cyclohexylpurin-6-amine; 9-Cyclohexyl-9H-purin-6-amine; 9H-Purin-6-amine, 9-cyclohexyl-; CHEMBL63783; NSC 19201; BRN 0220522; SQ 22244; N9-Cyclohexyladenine; 9-Cyclohexyl-9H-adenine; 6-Amino-9-cyclohexylpurine; Purine, 6-amino-9-cyclohexyl; SCHEMBL3245641; ZINC12513; 6-Amino-9-cyclohexyl-9H-purine; DTXSID20195164; 9-Cyclohexyl-9H-purin-6-ylamine; NSC19201; BDBM50013711; NSC-19201; DS-006123; WLN: T56 BN DN FN HNJ D- AL6TJ& IZ
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
Ethyl 6-[(4-methylbenzoyl)amino]-2-(2-phenylethyl)pyrazolo[3,4-d]pyrimidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410314; BDBM50072932
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
(2S,3S,4R,5R)-N-Ethyl-3,4-dihydroxy-5-[6-[(3-hydroxy-1-adamantyl)amino]purin-9-yl]oxolane-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3769641; BDBM50149596
Click to Show/Hide
|
||||
| Activity |
EC50 = 100000 nM
|
[26] | |||
| Compound Name |
Ethyl 2-(2,2-dimethylpropyl)-6-[[4-(trifluoromethyl)benzoyl]amino]pyrazolo[3,4-d]pyrimidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3114167; BDBM50495595
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
[3-(4-Bromothiophen-2-yl)-2-oxochromen-8-yl] acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3818635
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
(7-Chlorothiazolo[5,4-d]pyrimidin-2-yl)-p-tolyl-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827748; 7-Chloro-N-(p-tolyl)thiazolo[5,4-d]pyrimidin-2-amine; 7-chloro-N-p-tolylthiazolo[5,4-d]pyrimidin-2-amine; DTXSID20469397; BDBM50189090; KM2485; MFCD08437191; ZINC26896949; AK343407; BP-20006; BS-17760; (7-chlorothiazolo[5,4-d]pyrimidin-2-yl)p-tolylamine; N-(4-Methylphenyl)-7-chlorothiazolo[5,4-d]pyrimidine-2-amine; 7-Chloro-N-(4-methylphenyl)[1,3]thiazolo[5,4-d]pyrimidin-2-amine; 7-CHLORO-N-(4-METHYLPHENYL)-[1,3]THIAZOLO[5,4-D]PYRIMIDIN-2-AMINE
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
2,5,7,9-Tetramethylpyrido[3,4-b]indol-2-ium-6-ol;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL540656
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
7-Ethylpurin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-ethyl-7h-purin-6-amine; CHEMBL451363; 7-Ethyl Adenine; 7H-Purin-6-amine,7-ethyl-; 7-ethyladenine; 7H-Purin-6-amine, 7-ethyl-; 7-Ethyl-7H-adenine; 6-Amino-7-ethyl-7H-purine; SCHEMBL5801729; CTK4F3335; DTXSID00947143; BDBM50256843
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
8-[4-(2-Dimethylaminoethoxy)-3-methoxyphenyl]-1,3-dimethylxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472684; BDBM50279730
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[23] | |||
| Compound Name |
Chembl4286092
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50470489
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
Ethyl 2-(furan-2-yl)-5-morpholin-4-yl-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314910; BDBM50048028
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
Chembl4290655
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50470490
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
N-(4-Chloro-2-methylpyrazolo[3,4-d]pyrimidin-6-yl)-4-fluorobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3114144; BDBM50495619
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
4-(4-Chlorophenyl)-10-(2-phenylethyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21654; SCHEMBL5823674; BDBM50125914; 2-(4-Chlorophenyl)-7-phenylethylpyrazolo[4,3-e]1,2,4-triazolo-[1,5-c]pyrimidin-5-amine; 2-(4-Chloro-phenyl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[27] | |||
| Compound Name |
7-(Sec-Butyl)-7H-adenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL475030; BDBM50256897
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
Ethyl 2-(furan-2-yl)-5-(morpholin-4-ylamino)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314912; BDBM50048030
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
(7-Chlorothiazolo[5,4-d]pyrimidin-2-yl)phenylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3088335; 7-CHLORO-N-PHENYL-[1,3]THIAZOLO[5,4-D]PYRIMIDIN-2-AMINE; SCHEMBL5108536; CTK5F7871; DTXSID10467529; BDBM50189178; MFCD08437189; ZINC26896945; 2-phenylamino-7-chlorothiazolo[5,4-d]pyrimidine; 7-Chloro-N-phenylthiazolo[5,4-d]pyrimidin-2-amine; N-Phenyl-7-chlorothiazolo[5,4-d]pyrimidine-2-amine; Thiazolo[5,4-d]pyrimidin-2-amine,7-chloro-N-phenyl-; 7-Chloro-N-phenyl[1,3]thiazolo[5,4-d]pyrimidin-2-amine
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
7-Pyrrolidin-1-yl-N-(3,4,5-trimethoxyphenyl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828479; BDBM50189099
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
2-(Furan-2-yl)-5-[[4-(trifluoromethyl)phenyl]methylamino]-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314928; BDBM50047974
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
7-N,7-N-Diethyl-2-N-phenyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3088341; BDBM50189098
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
7-Morpholin-4-yl-N-phenyl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3088339; BDBM50189103
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
8-[4-(2-Diethylaminoethoxy)-3-methoxyphenyl]-1,3-dimethylxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL516188; BDBM50279731
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[23] | |||
| Compound Name |
N-(4-Chloro-2-methylpyrazolo[3,4-d]pyrimidin-6-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3114143; BDBM50495613
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
8-(2,5-Dioxo-2,5-dihydro-pyrrol-1-ylmethyl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL94234; BDBM50039680; 1,3-Dipropyl-8-[[(2,5-dioxo-2,5-dihydro-1H-pyrrol)-1-yl]methyl]xanthine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
7-(2,3-Dihydroxypropyl)-7H-adenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL474623; BDBM50257095
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
8-(3-Phenyl-3-oxo-1-propenyl)adenosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3350496; CHEMBL610346; BDBM50366686; Adenosine, 8-[(1E)-3-oxo-3-phenyl-1-propenyl]-
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
Chembl4285947
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50470477
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
N-[(4-Fluorophenyl)methyl]-2-(furan-2-yl)-5-phenoxy-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3753103; BDBM50137533
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
5-[(4-Chlorophenyl)methylamino]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314927; BDBM50048056
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
5-N-Cyclohexyl-7-N-[(4-fluorophenyl)methyl]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3754124; BDBM50137635
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
N-Phenyl-7-(4-piperidin-1-ylpiperidin-1-yl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3088346; BDBM50189094
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
2-Neopentyl-6-(4-methylbenzoylamino)-2H-pyrazolo[3,4-d]pyrimidine-4-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3114168; BDBM50495622
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
1-(4-Methoxyphenyl)-3-[11-methyl-4-[4-(trifluoromethyl)phenyl]-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1834695; BDBM50355154
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[13] | |||
| Compound Name |
7-(3-Hydroxypropyl)-7H-adenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL447623; BDBM50257053
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
5-N,7-N-Bis[(4-fluorophenyl)methyl]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3754080; BDBM50137637
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
N-Benzoyl-N-[4-chloro-2-(2,2-dimethylpropyl)pyrazolo[3,4-d]pyrimidin-6-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3114161; BDBM50495606
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
7-Chloro-N-(2-morpholin-4-ylethyl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828675; BDBM50189176
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
8-Hydroxy-3-(4-bromo-2-thienyl)-2H-1-benzopyran-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3818426; J3.552.501G
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
[8-Acetyloxy-3-(4-bromothiophen-2-yl)-2-oxochromen-7-yl] acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL8116689; CHEMBL3819570
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
9-[(2-Fluorophenyl)methyl]-N-methylpurin-6-amine;methanesulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445098
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
7-(2-Hydroxyethyl)adenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(6-aminopurin-7-yl)ethanol; 7-(2-Hydroxyethyl)-7H-adenine; CHEMBL466850; SCHEMBL4815870; DTXSID60452081; BDBM50257050; ZINC40913978; 2-(6-Amino-7H-purin-7-yl)ethanol; FT-0669615
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
1,3-Dimethyl-8-[3-methoxy-4-(2-piperidin-1-ylethoxy)-phenyl]xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472883; BDBM50279732
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[23] | |||
| Compound Name |
Ethyl 6-[(3,4-dichlorobenzoyl)amino]-2-(2-phenylethyl)pyrazolo[3,4-d]pyrimidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410316; BDBM50072930
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
(8-Acetyloxy-2-oxo-3-thiophen-2-ylchromen-7-yl) acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3818036
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
Ethyl 2-methyl-6-[[4-(trifluoromethyl)benzoyl]amino]pyrazolo[3,4-d]pyrimidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410304; BDBM50072937
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
N-(4-Methylphenyl)-7-pyrrolidin-1-yl-[1,3]thiazolo[5,4-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828214; BDBM50189055
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
Ethyl 2-methyl-6-[(4-methylbenzoyl)amino]pyrazolo[3,4-d]pyrimidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410305; BDBM50072938
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
(2-Amino-4,5-dihydrobenzo[e][1,3]benzothiazol-7-yl) acetate;hydroiodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL39106; SCHEMBL3991649; BDBM50451378
Click to Show/Hide
|
||||
| Activity |
EC50 = 158489.32 nM
|
[5] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 6 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Regadenoson
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Lexiscan (TN)
Click to Show/Hide
|
||||
| Activity |
Ki > 16460000 nM
|
[30] | |||
| Compound Name |
CGS 21680
Click to Show/Hide
|
Terminated | Compound Info | ||
| Synonyms |
2-(4-(2-Carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine; Cgs 21680; CGS-21680; 120225-54-9; UNII-T5HB1E831H; T5HB1E831H; CHEMBL331372; CGS21680; 4-(2-((6-Amino-9-(N-ethyl-beta-D-ribofuranuronamidosyl)-9H-purin-2-yl)amino)ethyl)benzenepropanoic acid; CHEBI:73283; CGS 21680 hydrochloride; Benzenepropanoic acid, 4-(2-((6-amino-9-(N-ethyl-beta-D-ribofuranuronamidosyl)-9H-purin-2-yl)amino)ethyl)-; 2-[p-(2-Carboxyethyl)phenylethyl-Amino]-5'-N-Ethylcarboxamido Adenosine; [3H]CGS 21680
Click to Show/Hide
|
||||
| Activity |
EC50 = 630957.34 nM
|
[26] | |||
| Compound Name |
11-Methyl-4-(4-nitrophenyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089427; BDBM50315625; 2-(4-Nitrophenyl)-8-methylpyrazolo[4,3-e]1,2,4-triazolo[1,5-c]-pyrimidin-5-amine
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[27] | |||
| Compound Name |
(2S,3S,4R,5R)-5-[2-[2-[4-[(3,5-Ditert-butyl-4-hydroxybenzoyl)amino]phenyl]ethylamino]-6-(2,2-diphenylethylamino)purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042312; BDBM50385956
Click to Show/Hide
|
||||
| Activity |
IC50 = 413267 nM
|
[31] | |||
| Compound Name |
6,7-Dimethoxy-4H-indeno[1,2-d][1,3]thiazol-2-amine;hydroiodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL43299; SCHEMBL3990222; BDBM50451379
Click to Show/Hide
|
||||
| Activity |
EC50 = 63095734.45 nM
|
[5] | |||
| Compound Name |
(2-Amino-4H-indeno[1,2-d][1,3]thiazol-5-yl) acetate;hydroiodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL39388; BDBM50451380
Click to Show/Hide
|
||||
| Activity |
EC50 = 501187233.6 nM
|
[5] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. | ||||
| REF 2 | Synthesis of eudistomin D analogues and its effects on adenosine receptors. Bioorg Med Chem. 2008 Apr 1;16(7):3825-30. | ||||
| REF 3 | Design, synthesis and biological evaluation of a bivalent micro opiate and adenosine A1 receptor antagonist. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6736-9. | ||||
| REF 4 | 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacolog... J Med Chem. 2005 Nov 3;48(22):6887-96. | ||||
| REF 5 | 2-Aminothiazoles: a new class of agonist allosteric enhancers of A(1) adenosine receptors. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1563-6. | ||||
| REF 6 | N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. | ||||
| REF 7 | Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor. J Med Chem. 2009 Dec 10;52(23):7897-900. | ||||
| REF 8 | New potent and selective A 1 adenosine receptor antagonists as potential tools for the treatment of gastrointestinal diseases. Eur J Med Chem. 2018 May 10;151:199-213. | ||||
| REF 9 | Fragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models. J Med Chem. 2015 Dec 24;58(24):9578-90. | ||||
| REF 10 | Discovery of simplified N?substituted pyrazolo[3,4-d]pyrimidine derivatives as novel adenosine receptor antagonists: efficient synthetic approaches, biological evaluations and molecular docking studies. Bioorg Med Chem. 2014 Mar 1;22(5):1751-65. | ||||
| REF 11 | A facile and novel synthesis of N(2)-, C(6)-substituted pyrazolo[3,4-d]pyrimidine-4 carboxylate derivatives as adenosine receptor antagonists. Eur J Med Chem. 2015 Mar 6;92:784-98. | ||||
| REF 12 | Discovery of 7-(Prolinol-N-yl)-2-phenylamino-thiazolo[5,4-d]pyrimidines as Novel Non-Nucleoside Partial Agonists for the A2A Adenosine Receptor: Prediction from Molecular Modeling. J Med Chem. 2016 Jun 23;59(12):5922-8. | ||||
| REF 13 | Does the combination of optimal substitutions at the C2-, N5- and N8-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A1 adenosine receptors?. Bioorg Med Chem. 2011 Oct 15;19(20):6120-34. | ||||
| REF 14 | Progress in the development of small molecules as new human A3 adenosine receptor ligands based on the 3-thiophenylcoumarin core. Medchemcomm. 2016;7:845-52. | ||||
| REF 15 | 5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors. Eur J Med Chem. 2016 Jan 27;108:529-541. | ||||
| REF 16 | [1,2,4]Triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: Modifications at the 8 position to reach selectivity towards A 3 adenosine receptor subtype. Eur J Med Chem. 2018 Sep 5;157:837-851. | ||||
| REF 17 | Diimidazo[1,2-c:4',5'-e]pyrimidines: adenosine agonist activity demonstrated by microphysiometry. Bioorg Med Chem Lett. 1998 Mar 17;8(6):691-4. | ||||
| REF 18 | Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1931-4. | ||||
| REF 19 | Novel thiazole-thiophene conjugates as adenosine receptor antagonists: synthesis, biological evaluation and docking studies. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1306-9. | ||||
| REF 20 | Discovery of 2-aminoimidazole and 2-amino imidazolyl-thiazoles as non-xanthine human adenosine A 3 receptor antagonists: SAR and molecular modeling studies. Medchemcomm. 2018 Mar 13;9(4):676-684. | ||||
| REF 21 | Scaffold decoration at positions 5 and 8 of 1,2,4-triazolo[1,5-c]pyrimidines to explore the antagonist profiling on adenosine receptors: a preliminary structure-activity relationship study. J Med Chem. 2014 Jul 24;57(14):6210-25. | ||||
| REF 22 | Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2916-9. | ||||
| REF 23 | Synthesis of a series of 8-(substituted-phenyl)xanthines and a study on the effects of substitution pattern of phenyl substituents on affinity for adenosine A(1) and A(2A) receptors. Eur J Med Chem. 2009 May;44(5):2122-7. | ||||
| REF 24 | New insight into adenosine receptors selectivity derived from a novel series of [5-substituted-4-phenyl-1,3-thiazol-2-yl] benzamides and furamides. Eur J Med Chem. 2013 May;63:924-34. | ||||
| REF 25 | Medicinal chemistry of A1 adenosine receptor modulators: pharmacological activities and therapeutic implications. J Med Chem. 2012 Jun 28;55(12):5676-703. | ||||
| REF 26 | Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity. J Med Chem. 2016 Feb 11;59(3):947-64. | ||||
| REF 27 | The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition. J Med Chem. 2010 Apr 22;53(8):3361-75. | ||||
| REF 28 | Substituted 1,3-dipropylxanthines as irreversible antagonists of A1 adenosine receptors. J Med Chem. 1994 Aug 19;37(17):2704-12. | ||||
| REF 29 | 9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors. J Med Chem. 1997 Jun 6;40(12):1768-70. | ||||
| REF 30 | Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2935-9. | ||||
| REF 31 | Synthesis and pharmacological evaluation of dual acting antioxidant A(2A) adenosine receptor agonists. J Med Chem. 2012 Apr 12;55(7):3521-34. | ||||
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