Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03LJX
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| Former ID |
DNC010371
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| Drug Name |
(3-amino-5-bromobenzofuran-2-yl)(phenyl)methanone
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| Synonyms |
CHEMBL591458; (3-Amino-5-bromo-benzofuran-2-yl)-phenyl-methanone; (3-amino-5-bromo-1-benzofuran-2-yl)(phenyl)methanone; SMR000010549; MLS000031617; AC1LCKCT; regid849115; Oprea1_732422; Oprea1_454471; MLS002534670; (3-amino-5-bromobenzofuran-2-yl)(phenyl)methanone; SCHEMBL13102601; ZINC97827; CTK5I8073; MolPort-000-164-762; HMS2395L21; STK078344; BDBM50306745; AKOS000510990; MCULE-9438936220; ST037109; BAS 01507283; EU-0018517; 3-amino-5-bromobenzo[d]furan-2-yl phenyl ketone; SR-01000523207; SR-01000523207-1
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H10BrNO2
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| Canonical SMILES |
C1=CC=C(C=C1)C(=O)C2=C(C3=C(O2)C=CC(=C3)Br)N
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| InChI |
1S/C15H10BrNO2/c16-10-6-7-12-11(8-10)13(17)15(19-12)14(18)9-4-2-1-3-5-9/h1-8H,17H2
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| InChIKey |
SBFAYONAJFSEPC-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adenosine A2a receptor (ADORA2A) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Rap1 signaling pathway | |||
| Calcium signaling pathway | ||||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Vascular smooth muscle contraction | ||||
| Parkinson's disease | ||||
| Alcoholism | ||||
| Pathwhiz Pathway | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Reactome | NGF-independant TRKA activation | |||
| Adenosine P1 receptors | ||||
| G alpha (s) signalling events | ||||
| Surfactant metabolism | ||||
| WikiPathways | Nucleotide GPCRs | |||
| Monoamine Transport | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| NGF signalling via TRKA from the plasma membrane | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. J Med Chem. 2010 Feb 25;53(4):1799-809. | |||
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