Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T77365 | Target Info | |||
| Target Name | Adenosine A2a receptor (ADORA2A) | ||||
| Synonyms |
Adenosine receptor A2a; ADORA2; A2a Adenosine receptor; A(2A) adenosine receptor
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| Target Type | Successful Target | ||||
| Gene Name | ADORA2A | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 140 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Enprofylline
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|
Approved | Compound Info | ||
| Synonyms |
Enprofilina; Enprofyllinum; Nilyph; Oxeze; P 5679; D-4028; Enprofilina [INN-Spanish]; Enprofylline [USAN:INN]; Enprofyllinum [INN-Latin]; Enprofylline (USAN/INN); 3,7-Dihydro-3-propyl-1H-purine-2,6-dione; 3-Propyl-3,7-dihydro-purine-2,6-dione; 3-Propylxanthine; 3-n-Propylxanthine; 3-propyl-3,7-dihydro-1H-purine-2,6-dione; 3-propyl-7H-purine-2,6-dione
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| Activity |
Ki = 81300 nM
|
[1] | |||
| Compound Name |
Xanthine
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Phase 1 | Compound Info | ||
| Synonyms |
xanthine; 69-89-6; 2,6-Dihydroxypurine; Xanthin; 2,6-dioxopurine; Pseudoxanthine; Isoxanthine; 1H-Purine-2,6(3H,7H)-dione; Xanthic oxide; 1H-Purine-2,6-diol; 9H-Purine-2,6-diol; Purine-2,6-diol; 3,7-Dihydro-1H-purine-2,6-dione; 2,6(1,3)-Purinedion; 1H-Purine-2,6-dione, 3,7-dihydro-; 3,7-dihydropurine-2,6-dione; USAF CB-17; XAN; Purine-2(3H),6(1H)-dione; 2,6-Dioxo-1,2,3,6-tetrahydropurine; 3,9-dihydro-1H-purine-2,6-dione; 9H-Purine-2,6-(1H,3H)-dione; 1H-Purine-2,6-dione, 3,9-dihydro-; Purine-2,6-(1H,3H)-dione; 9H-xanthine
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Tecadenoson
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Discontinued in Phase 3 | Compound Info | ||
| Synonyms |
CVT-510; 204512-90-3; UNII-GZ1X96601Z; CHEMBL392149; GZ1X96601Z; (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(3R)-oxolan-3-yl]amino]purin-9-yl]oxolane-3,4-diol; BDBM50224766; Tecadenoson [USAN:INN]; Tecadenoson (USAN/INN); AC1L4KMO; SCHEMBL246787; GTPL5592; CHEMBL356254; DTXSID80174415; BDBM50138530; DB04954; N6-[3-(R)-tetrahydrofuranyl]adenosine; HY-19661; Adenosine, N-(3R)-tetrahydro-3-furanyl-; LS-190860; Adenosine, N-(3R)-tetrahydro-3-furanyl)-; CS-0016174; D06019; CVT-510; N-(3-Tetrahydrofuranyl)-6-aminopurine riboside; Selenocompounds
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| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
1-Propyl-3,7-dihydro-purine-2,6-dione
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Investigative | Compound Info | ||
| Synonyms |
1-Propylxanthine; 104285-82-7; CHEMBL39986; 1H-Purine-2,6-dione,3,9-dihydro-1-propyl-; 1-Propyl-3,7-dihydro-purine-2,6-dione; ACMC-1BNN6; AC1L2TY0; SCHEMBL4423680; SCHEMBL8930198; CTK4A2909; DTXSID10146367; IWBONKMODGBEOX-UHFFFAOYSA-N; BDBM50001490; 1-propyl-3,7-dihydropurine-2,6-dione; 1H-Purine-2,6-dione, 3,7-dihydro-1-propyl-
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| Activity |
EC50 = 62000 nM
|
[2] | |||
| Compound Name |
2'-Me-tecadenoson
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL400190; 2'-Me-tecadenoson; 2''-Me-tecadenoson
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| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
6-Hydroxy-5,7-dimethyl-beta-carboline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL458558; 6-Hydroxy-5,7-dimethyl-beta-carboline
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| Activity |
Ki ~ 100000 nM
|
[5] | |||
| Compound Name |
2-chloro-2'-C-methyl-tecadenoson
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL400782; 2-chloro-2''-C-methyl-tecadenoson
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| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
2-(1-Cyclohexyl-3-methyl-4-(quinoxalin-6-yl)-1H-pyrazol-5-ylamino)-5-methoxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258505; BDBM50327338
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
2-(3-Ethyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258730; BDBM50327341
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
2-(4-(Quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258731; SCHEMBL3306156; BDBM50327342; 2-[[2-(2-methylphenyl)-4-quinoxalin-6-ylpyrazol-3-yl]amino]benzoic acid; 2-{[4-(Quinoxalin-6-yl)-1-(2-methylphenyl)-1H-pyrazol-5-yl]amino}benzoic acid
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
5-Chloro-2-(3-methyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258283; SCHEMBL1819219; BDBM50327334; 5-chloro-2-[[5-methyl-2-(2-methylphenyl)-4-quinoxalin-6-ylpyrazol-3-yl]amino]benzoic acid
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
2-(1-(2-Ethylphenyl)-3-methyl-4-(quinoxalin-6-yl)-1H-pyrazol-5-ylamino)-5-methoxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258621; SCHEMBL1819035; BDBM50327339; 2-[[2-(2-ethylphenyl)-5-methyl-4-quinoxalin-6-ylpyrazol-3-yl]amino]-5-methoxybenzoic acid; 2-{[4-(Quinoxalin-6-yl)-1-(2-ethylphenyl)-3-methyl-1H-pyrazol-5-yl]amino}-5-methoxybenzoic acid
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
2-(4-(Quinoxalin-6-yl)-1-o-tolyl-3-(trifluoromethyl)-1H-pyrazol-5-ylamino)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258622; BDBM50327340
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
2-(1-(2-Chlorophenyl)-3-methyl-4-(quinoxalin-6-yl)-1H-pyrazol-5-ylamino)-5-methoxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258506; SCHEMBL3306001; BDBM50327323; 2-[[2-(2-chlorophenyl)-5-methyl-4-quinoxalin-6-ylpyrazol-3-yl]amino]-5-methoxybenzoic acid
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
2-(3-Methyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258396; SCHEMBL3305031; BDBM50327336; 2-[[5-methyl-2-(2-methylphenyl)-4-quinoxalin-6-ylpyrazol-3-yl]amino]benzoic acid
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
5-Methyl-2-(3-methyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258284; SCHEMBL3302210; BDBM50327335; 5-methyl-2-[[5-methyl-2-(2-methylphenyl)-4-quinoxalin-6-ylpyrazol-3-yl]amino]benzoic acid
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
2-(4-(8-Fluoroquinoxalin-6-yl)-3-methyl-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258850; SCHEMBL1819029; BDBM50327343; 2-[[4-(8-fluoroquinoxalin-6-yl)-5-methyl-2-(2-methylphenyl)pyrazol-3-yl]amino]benzoic acid; 2-{[4-(8-Fluoroquinoxalin-6-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl]amino}benzoic acid
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
5-Methoxy-2-(3-methyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258170; BDBM50327333
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
2,4,6-Trimethyl-2H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL100810; 2,4,6-trimethyltriazolo[4,5-d]pyrimidine-5,7-dione; CTK0A9356; DTXSID80506919; BDBM50040064; 2,4,6-Trimethyl-1,4-dihydro-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-dione; 2,4,6-Trimethyl-2,4-dihydro-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-dione; 2,4,6-Trimethyl-2H-1,2,3-triazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione; 2H-1,2,3-Triazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione, 2,4,6-trimethyl-
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| Activity |
Ki = 52800 nM
|
[7] | |||
| Compound Name |
Ethyl 3-(benzylthio)-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL87496; ethyl 3-benzylsulfanyl-4-oxo-6,7-dihydro-5H-2-benzothiophene-1-carboxylate; Maybridge1_004618; Oprea1_179327; SCHEMBL5667457; CTK0H3425; HMS554J20; DTXSID80381142; C18H18O3S2; ZINC125868; BDBM50048454; MFCD00085055; AKOS015908647; AS-9285; CCG-239856; MCULE-5616294204; DB-064852; FT-0625989; Y7810; W-206029; ethyl 3-(benzylthio)-4-oxo-4,5,6,7-tetrahydro-2-benzothiophene-1-carboxylate
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| Activity |
Ki = 54300 nM
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[8] | |||
| Compound Name |
4-[2-[[6-Amino-9-methyl-8-(triazol-1-yl)purin-2-yl]amino]ethyl]phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2381764; BDBM50491461
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| Activity |
IC50 = 54954.09 nM
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[9] | |||
| Compound Name |
2-Cyclopentyl-4,6-dimethyl-2,4-dihydro-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL101525; BDBM50040055; 1,3-dimethyl-8-cyclopentyl-8-azaxanthine; 2-Cyclopentyl-4,6-dimethyl-2H-1,2,3-triazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione
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| Activity |
Ki = 58000 nM
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[7] | |||
| Compound Name |
(10As)-2-benzyl-1,5,10,10a-tetrahydroimidazo[1,5-b]isoquinolin-3-imine;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3741290; BDBM50499696
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| Activity |
Ki = 64000 nM
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[10] | |||
| Compound Name |
3-Ethylxanthine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL131181; 3-Ethyl-1H-purine-2,6(3H,7H)-dione; 3-ethyl-7H-purine-2,6-dione; 3-ethylxanthin; NSC515505; SCHEMBL7466316; CTK8I6477; DTXSID80325667; BDBM50001502; AKOS023092889; NSC-515505; 3-Ethyl-3,7-dihydro-purine-2,6-dione
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| Activity |
EC50 = 69200 nM
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[2] | |||
| Compound Name |
6-Amino-2-(2,2-dimethylpropyl)pyrazolo[3,4-d]pyrimidine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410296; BDBM50072918
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| Activity |
Ki ~ 80000 nM
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[11] | |||
| Compound Name |
6-Hydroxy-5,7,9-trimethyl-beta-carboline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL458409; BDBM50251139
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| Activity |
Ki = 80600 nM
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[5] | |||
| Compound Name |
1-Ethyl-3,7-dihydro-1H-purine-2,6-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL127167; 1H-Purine-2,6-dione, 1-ethyl-3,7-dihydro-; ethylxanthine; 1-Ethylxanthine; ACMC-20m72v; SCHEMBL380135; SCHEMBL9240979; CTK0D8111; DTXSID70579758; BDBM50001517; 1-ethyl-3,7-dihydropurine-2,6-dione; 1-Ethyl-3,7-dihydro-purine-2,6-dione
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| Activity |
EC50 = 96200 nM
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[2] | |||
| Compound Name |
2-N-(4-Chlorophenyl)-7-N,7-N-dimethyl-[1,3]thiazolo[5,4-d]pyrimidine-2,7-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3088350; BDBM50189065
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| Activity |
Ki ~ 100000 nM
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[12] | |||
| Compound Name |
1-(4-Methoxyphenyl)-3-[11-methyl-4-(4-phenylphenyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1834696; BDBM50355155
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| Activity |
Ki ~ 100000 nM
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[13] | |||
| Compound Name |
7-(2-Hydroxypropyl)-7H-adenine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL475456; 1-(6-aminopurin-7-yl)propan-2-ol; BDBM50257056
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| Activity |
Ki ~ 100000 nM
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[14] | |||
| Compound Name |
Ethyl 6-(dibenzoylamino)-2-methylpyrazolo[3,4-d]pyrimidine-4-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410317; BDBM50072929
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| Activity |
Ki ~ 100000 nM
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[11] | |||
| Compound Name |
2-Amino-3-formyl-6,7-dimethylchromone
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Investigative | Compound Info | ||
| Synonyms |
2-amino-6,7-dimethyl-4-oxochromene-3-carbaldehyde; 2-Amino-6,7-dimethyl-4-oxo-4H-chromene-3-carbaldehyde; CHEMBL601874; 2-amino-6,7-dimethyl-3-formylchromone; ACMC-20ao5c; SCHEMBL13978669; CTK5H7280; DTXSID40343645; ZINC1081182; BDBM50306758; AKOS024356713; MCULE-2949170836; ST50984717; 2-Amino-3-formyl-6,7-dimethyl-4H-1-benzopyran-4-one; 2-Amino-6,7-dimethyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde; 2-AMINO-6,7-DIMETHYL-4-OXO-4H-1-BENZOPYRAN-3-CARBOXALDEHYD; 4H-1-Benzopyran-3-carboxaldehyde, 2-amino-6,7-dimethyl-4-oxo-
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| Activity |
Ki ~ 100000 nM
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[15] | |||
| Compound Name |
N-[5-(5,6-Dimethyl-4-oxo-3H-thieno[2,3-d]pyrimidin-2-yl)-4-phenyl-1,3-thiazol-2-yl]furan-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391838; BDBM50492062
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| Activity |
Ki ~ 100000 nM
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[16] | |||
| Compound Name |
(R)-Tert-butyl 3-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-6-ylamino)pyrrolidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL240277; BDBM50225884
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| Activity |
Ki ~ 100000 nM
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[3] | |||
| Compound Name |
6-(([1,2,4]Triazolo[4,3-a]pyridin-3-ylthio)methyl)-N2-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL601224; ZINC9512253; BDBM50306796; AKOS001278682; MCULE-3557734815; Z153001636
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| Activity |
Ki ~ 100000 nM
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[15] | |||
| Compound Name |
Ethyl 6-[bis(3,4-difluorobenzoyl)amino]-2-methylpyrazolo[3,4-d]pyrimidine-4-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410319; BDBM50072927
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| Activity |
Ki ~ 100000 nM
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[11] | |||
| Compound Name |
2,5,7-Trimethyl-9H-pyrido[3,4-b]indol-2-ium-6-ol;iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL541164
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| Activity |
Ki ~ 100000 nM
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[5] | |||
| Compound Name |
3-Amino-N-(2-chlorophenyl)thieno[2,3-b]pyridine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL600593; BBL026976; BDBM50306784; STL365274; ZINC10010818; AKOS003407339; MCULE-5900780586; H7566
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| Activity |
Ki ~ 100000 nM
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[15] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-Amino-2-(4-butyl-3,5-dimethyl-pyrazol-1-yl)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL443495; BDBM50119137
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| Activity |
Ki ~ 100000 nM
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[17] | |||
| Compound Name |
N-[4-Chloro-2-(2,2-dimethylpropyl)pyrazolo[3,4-d]pyrimidin-6-yl]-4-(trifluoromethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3114153; BDBM50495614
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| Activity |
Ki ~ 100000 nM
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[18] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-Amino-8-(2-phenylethynyl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3350497; 8-phenylethynyladenosine; 8-(phenylethynyl)adenosine; CHEMBL611516; SCHEMBL4378434; BDBM50366687
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| Activity |
Ki ~ 100000 nM
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[19] | |||
| Compound Name |
(2R,3S,4R)-2-(Hydroxymethyl)-5-[6-[[(2S)-2-[(3-methylphenyl)methoxy]cyclopentyl]amino]purin-9-yl]oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3674592; SCHEMBL12192999; BDBM99196; US8501708, 16
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| Activity |
Ki ~ 100000 nM
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[20] | |||
| Compound Name |
2-(Furan-2-yl)-5-(methylamino)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314915; BDBM50048033
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| Activity |
Ki ~ 100000 nM
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[21] | |||
| Compound Name |
2-{4-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl]-pyrazol-1-yl}-N-methyl-acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL316729; BDBM50119146
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| Activity |
Ki ~ 100000 nM
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[17] | |||
| Compound Name |
Ethyl 6-(dibenzoylamino)-2-(2-phenylethyl)pyrazolo[3,4-d]pyrimidine-4-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410321; BDBM50072925
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
N-[4-(4-Fluorophenyl)-11-methyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091134; BDBM50315634; N-[2-(4-Fluorophenyl)-8-methylpyrazolo[4,3-e][1,2,4]triazolo-[1,5-c]pyrimidin-5-yl]benzamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[22] | |||
| Compound Name |
N6-Cyclopentyl-9H-(2-C-methyl-5-chloro-5-deoxy-beta-D-ribofuranosyl)adenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL515330; BDBM50267397
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[23] | |||
| Compound Name |
Ethyl 2-[[2-(acetyloxyamino)-4-(dimethylamino)-1,3-thiazole-5-carbonyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3403730; BDBM50064622
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[24] | |||
| Compound Name |
N-(4-Acetylphenyl)-3-amino-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL600388; SCHEMBL16217123; ZINC691545; BDBM50306783; MCULE-2406219459; SR-01000112001; SR-01000112001-1
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
Ethyl 4-[[5-[2-[4-(4-ethoxy-4-oxobutoxy)phenyl]ethylamino]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]amino]butanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2381772; BDBM50491450
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-Amino-2-[(phenylimino)methyl]-9,10-anthracenedione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602486; CTK4E7711; BDBM50306774; MCULE-6691919832; SR-01000209985; SR-01000209985-1; 1-Amino-2-((phenylimino)methyl)anthracene-9,10-dione; 9,10-Anthracenedione,1-amino-2-[(phenylimino)methyl]-; (E)-1-amino-2-((phenylimino)methyl)anthracene-9,10-dione
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
[(2R,3R,4R,5R)-5-[2-Chloro-6-[[(3R)-oxolan-3-yl]amino]purin-9-yl]-3,4-dihydroxy-4-methyloxolan-2-yl]methyl N-methylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254693; BDBM50224773; 2-chloro-N6-(R)-3-tetrahydrofuranyl-9H-(2-C-methyl-5-N-methylcarbamoyl-beta-D-ribofuranosyl)adenine
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-Amino-2-(3,5-dimethyl-4-propyl-pyrazol-1-yl)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98973; BDBM50119159
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
8-Bromo-9-cycloheptyl-9H-adenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL474396; BDBM50257003
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
Ethyl 6-[bis(4-bromobenzoyl)amino]-2-methylpyrazolo[3,4-d]pyrimidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410318; BDBM50072928
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
N-[4-(4-Methoxyphenyl)-11-methyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091938; BDBM50315647; N-[2-(4-Methoxyphenyl)-8-methylpyrazolo[4,3-e][1,2,4]triazolo-[1,5-c]pyrimidin-5-yl]phenylacetamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[22] | |||
| Compound Name |
2-(6-Amino-1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-oxoethyl 2-methylquinoline-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL600416; BDBM50306763; ZINC10467349; AKOS033774817; MCULE-3293346791; Z215459346
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
5-(2-Amino-9H-purin-6-ylthio)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL601021; ZINC6622433; BDBM50306762; AKOS024344580; MCULE-6954264640
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
2-Amino-6-(1-(2-chlorobenzylamino)-1-oxopropan-2-ylthio)-5-cyano-N-phenylnicotinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL605791; BDBM50306750; AKOS033074887; MCULE-6634514769; Z113743170
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-Amino-2-(1-decyl-1H-pyrazol-4-yl)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98958; SCHEMBL272221; BDBM50119136; (2R,3R,4S,5R)-2-[6-amino-2-(1-decylpyrazol-4-yl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
7-Methyladenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-Methyl-7H-purin-6-amine; 6-Amino-7-methylpurine; N7-Methyladenine; 7H-Purin-6-amine, 7-methyl-; Adenine, 7-methyl-; 7-methylpurin-6-amine; 7H-Purin-6-amine, 7-methyl- (9CI); CHEMBL449346; MFCD00127790; NSC 7857; 7-Methyl-7H-adenine; 7-methyl-6-purinamine; 7-Methyladenine, 97%; 7-methylpurine-6-ylamine; 7-methyl-N7-Methyladenine; DSSTox_CID_29335; DSSTox_RID_83451; DSSTox_GSID_49376; SCHEMBL26976; Adenine, 7-methyl- (8CI); 7-Methyl-7H-purin-6-ylamine; DTXSID9049376; 7-Methyl-7H-purin-6-amine #; CTK5H2669; NSC7857; ZINC901320; KS-000018VI; NSC-7857; Tox21_202951; 5887AC; BDBM50240579; AKOS000320617; AKOS006378195; NCGC00260497-01; SY250877; TS-00058; N-ACETYL-DL-2-AMINO-N-BUTYRICACID; FT-0657514; ST50298865; 7-methyl-7H-purin-6-amine (ACD/Name 4.0); C02241; 7-methyl-7H-purin-6-ylamine (ACD/Name 4.0); 935M693; A844638; J-640190; J-800191; W-204088; 6-Amino-7-methylpurine, 7-Methyl-7H-purin-6-amine; Q27103966
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
Chembl4294838
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
Ki ~ 100000 nM
|
[25] | |||
| Compound Name |
N-(4-Chlorophenyl)-7-(4-methylpiperazin-1-yl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3088333; BDBM50189177
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
4-[2-[(6-Amino-9-methylpurin-2-yl)amino]ethyl]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2381765; BDBM50491453
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1,3-Dimethyl-8-[3-methoxy-4-(2-morpholin-4-ylethoxy)-phenylxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL520212; BDBM50279420
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[26] | |||
| Compound Name |
Ethyl 2-propan-2-yl-6-[[4-(trifluoromethyl)benzoyl]amino]pyrazolo[3,4-d]pyrimidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410308; BDBM50072941
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
8-(1-Hexynyl)adenosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2181966; BDBM50397720; Adenosine, 8-(1-hexynyl)-; CHEMBL610640; BDBM50366688; (2R,3R,4S,5R)-2-(6-amino-8-hex-1-ynylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[27] | |||
| Compound Name |
1-(4-Fluorophenyl)-3-[11-methyl-4-(4-phenylphenyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1834629; BDBM50355151
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[13] | |||
| Compound Name |
(R)-Benzyl 3-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-6-ylamino)pyrrolidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL240278; BDBM50225878
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
9H-Purin-6-amine, 9-(2-methylpropyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL503566; 9-Isobutyladenine; 9-Isobutyl-9H-adenine; SCHEMBL12620928; BDBM50256948; AKOS012922846
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
7-Isobutyl-7H-adenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472147; BDBM50256949
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
Ethyl 4-amino-2-(3-amino-3-oxopropylthio)pyrimidine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591926; ZINC6900268; BDBM50306757; AKOS001918057; CCG-169720; MCULE-8529837969; SR-01000149717; SR-01000149717-1; ethyl 4-amino-2-[(3-amino-3-oxopropyl)thio]pyrimidine-5-carboxylate
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
2-{4-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl]-pyrazol-1-yl}-N-propyl-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98023; BDBM50119154
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
Methyl 12-[4-[4-[(E)-2-(1,3-diethyl-7-methyl-2,6-dioxopurin-8-yl)ethenyl]-2-methoxyphenoxy]butanoylamino]dodecanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2381769; BDBM50491451
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
9-Cyclohexyladenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
9-cyclohexylpurin-6-amine; 9-Cyclohexyl-9H-purin-6-amine; 9H-Purin-6-amine, 9-cyclohexyl-; CHEMBL63783; NSC 19201; BRN 0220522; SQ 22244; N9-Cyclohexyladenine; 9-Cyclohexyl-9H-adenine; 6-Amino-9-cyclohexylpurine; Purine, 6-amino-9-cyclohexyl; SCHEMBL3245641; ZINC12513; 6-Amino-9-cyclohexyl-9H-purine; DTXSID20195164; 9-Cyclohexyl-9H-purin-6-ylamine; NSC19201; BDBM50013711; NSC-19201; DS-006123; WLN: T56 BN DN FN HNJ D- AL6TJ& IZ
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
N-[4-(4-Bromophenyl)-11-methyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090241; BDBM50315636; N-[2-(4-Bromophenyl)-8-methylpyrazolo[4,3-e][1,2,4]triazolo-[1,5-c]pyrimidin-5-yl]benzamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[22] | |||
| Compound Name |
{[4-Amino-5-(ethoxycarbonyl)pyrimidin-2-yl]thio}acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(4-amino-5-ethoxycarbonylpyrimidin-2-yl)sulfanylacetic acid; CHEMBL601658; 2-(4-amino-5-(ethoxycarbonyl)pyrimidin-2-ylthio)acetic acid; 2-{[4-amino-5-(ethoxycarbonyl)pyrimidin-2-yl]sulfanyl}acetic acid; 5-Pyrimidinecarboxylicacid, 4-amino-2-[(carboxymethyl)thio]-, 5-ethyl ester; 2-[4-amino-5-(ethoxycarbonyl)pyrimidin-2-ylthio]acetic acid; ACMC-1BPEY; CTK4A9180; DTXSID40353648; ZINC191797; BDBM50306756; SBB017418; AKOS001106607; CCG-164989; MCULE-9683348702; ST078407; EC-000.1602; EN300-11576; AB00981099-01; Z57052845; 2-((4-Amino-5-(ethoxycarbonyl)pyrimidin-2-yl)thio)acetic acid; {[4-amino-5-(ethoxycarbonyl)-2-pyrimidinyl]sulfanyl}acetic acid
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
(1S,2R,4S)-2-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid 2-bromo-benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL430374; BDBM50225881
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
Ethyl 2-(2,2-dimethylpropyl)-6-[[4-(trifluoromethyl)benzoyl]amino]pyrazolo[3,4-d]pyrimidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3114167; BDBM50495595
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
(2R,3R,4R,5S)-2-[6-(Cyclopentylamino)purin-9-yl]-5-[(2-fluorophenyl)sulfanylmethyl]-3-methyloxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL523934; BDBM50267534; N6-Cyclopentyl-9H-[2-C-methyl-5-deoxy-5-(2-fluorophenylthio)-beta-D-ribofuranosyl]adenine
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[23] | |||
| Compound Name |
8-Amino-N-(4-fluorophenyl)-3,4-dihydro-2H-1,4-ethanothieno[2,3-b][1,5]naphthyridine-7-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL601207; ZINC4623467; BDBM50306781; STK686278; AKOS001754452; MCULE-7140978933
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
N-[11-Methyl-4-(4-nitrophenyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090243; BDBM50315638; N-[2-(4-Nitrophenyl)-8-methylpyrazolo[4,3-e][1,2,4]triazolo-[1,5-c]pyrimidin-5-yl]benzamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[22] | |||
| Compound Name |
[3-(4-Bromothiophen-2-yl)-2-oxochromen-8-yl] acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3818635
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[28] | |||
| Compound Name |
3-Methylxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2,6-Dihydroxy-3-methylpurine; 3-Methyl-1H-purine-2,6(3H,7H)-dione; 3-methyl-7H-purine-2,6-dione; Xanthine, 3-methyl-; 3-METHYL XANTHINE; 1H-Purine-2,6-dione, 3,7-dihydro-3-methyl-; 3,7-Dihydro-3-methyl-1H-purine-2,6-dione; UNII-WS6X982OEC; MFCD00005580; 3-methyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione; 3-methyl-7H-xanthine; CHEMBL619; WS6X982OEC; 3-methyl-3,7-dihydro-1H-purine-2,6-dione; 3-Methyl-3,9-dihydro-purine-2,6-dione; 3-Methylxanthine, 97%; 3-Methyl-3,9-dihydro-1H-purine-2,6-dione; 3-methyl-1,3-dihydropurine-2,6-dione; CCRIS 5817; 3-methyl-3,7(9)-dihydro-purine-2,6-dione; EINECS 214-058-1; NSC 515466; 3-methyl-xanthine; 3-methyl-9H-xanthine; Spectrum_001898; Theophylline Impurity B; 3-methyl-1H-purine-2,6(3H,9H)-dione; SpecPlus_000737; Spectrum2_000502; Spectrum3_001652; Spectrum4_001571; Spectrum5_001544; 3-Methylxanthine, 98%; N(1)-demethyltheophylline; 2-oxo-3-methylhypoxanthine; ACMC-1BT43; Oprea1_233226; Oprea1_288071; BSPBio_003403; KBioGR_002122; KBioSS_002428; KSC492Q5R; BIDD:GT0266; DivK1c_006833; SCHEMBL237146; SPECTRUM1504182; SPBio_000423; ACMC-2098x5; SCHEMBL8663339; Theophylline Related Compound B; 3-Methyl-3H-purine-2,6-diol; 3-methyl-9H-purine-2,6-dione; CTK3J2858; KBio1_001777; KBio2_002422; KBio2_004990; KBio2_007558; KBio3_002623; KS-00000DPJ; DTXSID90148107; 1-METHYLXANTHINE (1-MX); BCP18161; ZINC4685854; ANW-15831; BBL012772; BDBM50001515; CCG-39565; GEO-01981; NSC515466; s6186; SBB002920; STK776266; WLN: T56 BM DN FNVMVJ F1; AKOS002272340; AKOS004120009; AKOS006221835; ZINC100459831; CS-W020049; DS-1280; LS21223; MCULE-1015315695; NSC-515466; 3-methyl-3,7-dihydropurine-2,6-dione; 1H-Purine-2, 3,7-dihydro-3-methyl-; NCGC00095330-01; NCGC00095330-02; NCGC00178088-01; 3-Methyl-3,7-dihydro-purine-2,6-dione; BR-72940; HY-50723; SC-14084; SY031706; AB0034663; DB-040769; ST4105010; 3,9-dihydro-3-methyl-1H-purine-2,6-dione; AM20080030; FT-0616197; M2073; X8852; C16357; S-2007; 3-Methyl-3,9-dihydro-1H-purine-2,6-dione #; 3-methyl-3,9-dihydro-2H,6H-purine-2,6-dione; 076M228; A801730; J-505016; W-108741; Q27888118; 1H-Purine-2,6-dione, 3,7-dihydro-3-methyl- (9CI); Z1741977122
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-(6-Amino-9H-purin-8-ylsulfanyl)-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-[(6-amino-7H-purin-8-yl)sulfanyl]propanoic acid; 3-((6-amino-9h-purin-8-yl)thio)propanoic acid; 3-(6-aminopurin-8-ylthio)propanoic acid; 3-[(6-amino-9h-purin-8-yl)thio]propanoic acid; Oprea1_209146; Oprea1_851552; MLS000714396; 3-[(6-amino-9H-purin-8-yl)sulfanyl]propanoic acid; CHEMBL510282; Propanoic acid, 3-[(6-amino-9H-purin-8-yl)thio]-; BDBM26596; CTK7J4634; CTK8F4723; HMS1618O05; HMS2749I06; ZINC281814; A3NI1, 21; SBB011786; AKOS000296929; CCG-118033; MCULE-5569979161; SMR000274375; ST50218411; 3-(6-Amino-9H-purin-8-ylsulfanyl)-propionicacid; 3-(6-amino-9 h-purin-8-ylsulfanyl)-propionic acid; 3-[(6-amino-9h-purin-8-yl) sulfanyl] propanoic acid
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
(2R,3R,4R,5S)-2-[6-(2-Bicyclo[2.2.1]heptanylamino)-2-chloropurin-9-yl]-5-[(2-fluorophenyl)sulfanylmethyl]-3-methyloxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489628; BDBM50267537
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[23] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[2-Chloro-6-(4-chloro-2-fluoroanilino)purin-9-yl]-5-[(3,5-dimethylpyrazol-1-yl)methyl]oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4078360; BDBM50247446
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[29] | |||
| Compound Name |
3-(2-{3-Amino-8-thia-4,6,11-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraen-11-yl}-2-oxoethyl)-1,3-thiazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL600818; BDBM50306752; ZINC12606624; AKOS033541610; MCULE-4872575516; Z168758158
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
2,5,7,9-Tetramethylpyrido[3,4-b]indol-2-ium-6-ol;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL540656
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[5] | |||
| Compound Name |
N-[4-(4-Chlorophenyl)-11-methyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089905; BDBM50315635; N-[2-(4-Chlorophenyl)-8-methylpyrazolo[4,3-e][1,2,4]triazolo-[1,5-c]pyrimidin-5-yl]benzamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[22] | |||
| Compound Name |
{4-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl]-pyrazol-1-yl}-acetic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100992; BDBM50119140; 2-[1-(2-Oxo-2-methoxyethyl)-1H-pyrazole-4-yl]adenosine
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
2-(Furan-2-yl)-5-[(4-phenylphenyl)methylamino]-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314929; BDBM50047975
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
(2R,3R,4S,5R)-2-{6-Amino-2-[1-(2-hydroxy-ethyl)-1H-pyrazol-4-yl]-purin-9-yl}-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL328642; BDBM50119158
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
Chembl4290655
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50470490
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[30] | |||
| Compound Name |
Acetamide, 2-(5-amino-2-phenyl-2H-[1,2,4]triazol-3-ylsulfanyl)-N-methyl-N-phenyl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602481; SMR000096116; MLS000119187; ChemDiv2_005342; MLS002548833; MLS002589821; HMS1384C18; HMS2248O21; ZINC111440; BDBM50306754; STK773711; AKOS001727085; MCULE-9059477111; IDI1_004057; ST093636; SR-01000091949; SR-01000091949-1; 2-(3-amino-1-phenyl(1,2,4-triazol-5-ylthio))-N-methyl-N-phenylacetamide; 2-(3-amino-1-phenyl-1H-1,2,4-triazol-5-ylthio)-N-methyl-N-phenylacetamide; 2-[(3-amino-1-phenyl-1H-1,2,4-triazol-5-yl)sulfanyl]-N-methyl-N-phenylacetamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-Amino-2-(5-methyl-3-phenyl-pyrazol-1-yl)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL317053; BDBM50119135
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
(1S,2R,4S)-2-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL240487; BDBM50225882
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
7-(Sec-Butyl)-7H-adenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL475030; BDBM50256897
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
Ethyl 2-(furan-2-yl)-5-(morpholin-4-ylamino)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314912; BDBM50048030
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
2-Amino-6-((2-(2,4-dimethylphenyl)-2-oxoethyl)thio)-4-(thiophen-2-yl)pyridine-3,5-dicarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603493; ChemDiv1_001712; HMS591N18; BDBM50306759; STK806068; ZINC19805640; AKOS000522747; MCULE-8844685778; ST50337661; AB00684068-01; Z56766223; F0182-0001
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
2-(2H-1,3-Benzodioxol-5-yl)-5-imino-9-methyl-5H-chromeno[3,4-c]pyridin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602480; HMS1781P12; ZINC8150762; BDBM50306753; AKOS008039506; MCULE-3186443215; SR-01000066141; SR-01000066141-1; Z85934667; 2-(benzo[d][1,3]dioxol-5-yl)-5-imino-9-methyl-5H-chromeno[3,4-c]pyridin-4-amine
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
5-(Benzhydrylamino)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314930; BDBM50047976
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
(2R,3R,4R,5S)-2-[6-(2-Bicyclo[2.2.1]heptanylamino)purin-9-yl]-5-[(2-fluorophenyl)sulfanylmethyl]-3-methyloxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489428; BDBM50267536; N6-(+/-)-endo-Norbornyl-9H-[2-C-methyl-5-deoxy-5-(2-fluorophenylthio)-beta-D-ribofuranosyl]adenine
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[23] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-Amino-2-(1H-pyrazol-4-yl)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98849; SCHEMBL272915; BDBM50119147; (2R,3R,4S,5R)-2-[6-amino-2-(1H-pyrazol-4-yl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
2-(4-Amino-phenyl)-1H-benzoimidazol-4-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602467; 2-(4-aminophenyl)-1H-benzo[d]imidazol-4-amine; 2-(4-aminophenyl)-1H-benzimidazol-4-amine; SCHEMBL6439291; CTK7D7217; ZINC801193; 4,4'-diamino-2-phenylbenzimidazole; BDBM50306755; AKOS000636705; CCG-116969; MCULE-3025247585; 2-(4-Aminophenyl)-1H-benzoimidazol-4-ylamine; 2-(4-amino-phenyl)-1 h-benzoimidazol-4-ylamine
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
7-(2,3-Dihydroxypropyl)-7H-adenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL474623; BDBM50257095
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
{4-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl]-pyrazol-1-yl}-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL319949; BDBM50119163
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
Dimethyl 2,6-diamino-4-(4-methylphenyl)furo[2,3-f][1]benzofuran-3,7-dicarboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL600861; Oprea1_166877; HMS1615B08; ZINC1071857; BDBM50306761; STK740284; AKOS001686092; CCG-115014; MCULE-8193624995; SR-01000085106; SR-01000085106-1
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-(3-Fluoro-4-hydroxyanilino)purin-9-yl]-5-(methoxymethyl)oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
GR-190178; SCHEMBL6559897; CHEMBL2261342; BDBM50487262
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[31] | |||
| Compound Name |
5-[(4-Chlorophenyl)methylamino]-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314927; BDBM50048056
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
2-((4-Amino-6-(o-tolylamino)-1,3,5-triazin-2-yl)methylthio)-N-o-tolylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL605584; MLS000334258; HMS2604P14; ZINC2617526; BDBM50306795; AKOS034366286; MCULE-7740660617; SMR000249016; SR-01000054744; SR-01000054744-1; Z45354635
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
Chembl4167197
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50369693
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[32] | |||
| Compound Name |
(1S,2S,3R,4R,5S)-1-(6-Aminopurin-9-yl)-4-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2112095
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[33] | |||
| Compound Name |
2-[(3-Amino-2-oxo-2H-chromen-4-yl)amino]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL605783; ChemDiv2_000243; Oprea1_357646; Oprea1_399515; 2-[(3-amino-2-oxochromen-4-yl)amino]benzoic acid; HMS1369L01; BDBM50306765; STK368401; ZINC19606826; AKOS001482909; MCULE-2066288789; N-(3-amino-4-coumarinyl)anthranilic acid; ST50908830; UNM000011033001; AB00082155-01; SR-01000397499; SR-01000397499-1; 2-(3-amino-2-oxo-2H-chromen-4-ylamino)benzoic acid
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
N-Phenyl-7-(4-piperidin-1-ylpiperidin-1-yl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3088346; BDBM50189094
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
2-{4-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl]-pyrazol-1-yl}-N-ethyl-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL99554; BDBM50119139
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
2-Neopentyl-6-(4-methylbenzoylamino)-2H-pyrazolo[3,4-d]pyrimidine-4-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3114168; BDBM50495622
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
(1S,2R,4S)-2-[9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamino]-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid 2-chloro-benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL392720; BDBM50225876
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R,3R,4R,5S)-2-[2-Chloro-6-(cyclopentylamino)purin-9-yl]-5-[(2-fluorophenyl)sulfanylmethyl]-3-methyloxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489226; BDBM50267535; 2-Chloro-N6-cyclopentyl-9H-[2-C-methyl-5-deoxy-5-(2-fluorophenylthio)-beta-D-ribofuranosyl]adenine
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[23] | |||
| Compound Name |
N-[4-(4-Methoxyphenyl)-11-methyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090242; BDBM50315637; N-[2-(4-Methoxyphenyl)-8-methylpyrazolo[4,3-e][1,2,4]triazolo-[1,5-c]pyrimidin-5-yl]benzamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[22] | |||
| Compound Name |
N-[4-(4-Bromophenyl)-11-methyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091937; BDBM50315646; N-[2-(4-Bromophenyl)-8-methylpyrazolo[4,3-e][1,2,4]triazolo-[1,5-c]pyrimidin-5-yl]phenylacetamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[22] | |||
| Compound Name |
1-(4-Methoxyphenyl)-3-[11-methyl-4-[4-(trifluoromethyl)phenyl]-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1834695; BDBM50355154
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[4-(4-Bromophenyl)-11-(2-phenylethyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091267; BDBM50315642; N-[2-(4-Bromophenyl)-8-phenylethyl-pyrazolo[4,3-e][1,2,4]-triazolo[1,5-c]pyrimidin-5-yl]benzamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[22] | |||
| Compound Name |
Ethyl 6-(dibenzoylamino)-2-propan-2-ylpyrazolo[3,4-d]pyrimidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410320; BDBM50072926
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
Ethyl 1-amino-3-bromo-6-(4-bromophenyl)benzo[c]thiophene-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL601229; BDBM50306764
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
7-(3-Hydroxypropyl)-7H-adenine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL447623; BDBM50257053
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
1-((R)-3-(9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-6-ylamino)pyrrolidin-1-yl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL391030; BDBM50225879
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
N-Benzoyl-N-[4-chloro-2-(2,2-dimethylpropyl)pyrazolo[3,4-d]pyrimidin-6-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3114161; BDBM50495606
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
2-((4-Amino-6-(p-tolylamino)-1,3,5-triazin-2-yl)methylthio)-N-cyclopropylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602266; BDBM50306794; ZINC12610133; AKOS034788018; MCULE-3087376469; Z99538389; 2-[({4-amino-6-[(4-methylphenyl)amino]-1,3,5-triazin-2-yl}methyl)sulfanyl]-N-cyclopropylacetamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
7-Chloro-N-(2-morpholin-4-ylethyl)-[1,3]thiazolo[5,4-d]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828675; BDBM50189176
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
8-Hydroxy-3-(4-bromo-2-thienyl)-2H-1-benzopyran-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3818426; J3.552.501G
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[28] | |||
| Compound Name |
[8-Acetyloxy-3-(4-bromothiophen-2-yl)-2-oxochromen-7-yl] acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL8116689; CHEMBL3819570
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[28] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-Amino-2-(1-methyl-1H-pyrazol-4-yl)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318264; SCHEMBL272005; BDBM50119162; 2-(1-Methyl-1H-pyrazole-4-yl)adenosine; (2R,3R,4S,5R)-2-[6-amino-2-(1-methylpyrazol-4-yl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
7-(2-Hydroxyethyl)adenine
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Investigative | Compound Info | ||
| Synonyms |
2-(6-aminopurin-7-yl)ethanol; 7-(2-Hydroxyethyl)-7H-adenine; CHEMBL466850; SCHEMBL4815870; DTXSID60452081; BDBM50257050; ZINC40913978; 2-(6-Amino-7H-purin-7-yl)ethanol; FT-0669615
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| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
2-{4-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl]-pyrazol-1-yl}-N,N-dimethyl-acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL100513; BDBM50119155
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| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
Ethyl 6-[(3,4-dichlorobenzoyl)amino]-2-(2-phenylethyl)pyrazolo[3,4-d]pyrimidine-4-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410316; BDBM50072930
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| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
(8-Acetyloxy-2-oxo-3-thiophen-2-ylchromen-7-yl) acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3818036
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| Activity |
Ki ~ 100000 nM
|
[28] | |||
| Compound Name |
Ethyl 2-methyl-6-[[4-(trifluoromethyl)benzoyl]amino]pyrazolo[3,4-d]pyrimidine-4-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410304; BDBM50072937
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||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
Tert-butyl N-[12-oxo-12-[3-[2-(2-oxo-1,3-dihydroindol-4-yl)ethyl-propylamino]propylamino]dodecyl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3394254; BDBM50059795
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| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
1,4-Diamino-N-butyl-9,10-dioxo-9,10-dihydroanthracene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL601628; ZINC5295335; BDBM50306775; AKOS024342779; MCULE-9763686391
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||||
| Activity |
Ki = 120000 nM
|
[15] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 14 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Nifedipine
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Adalat; Adalate; Adapine; Adapress; Afeditab; Alat; Aldipin; Alfadal; Alonix; Angipec; Anifed; Anpine; Aprical; Bonacid; Calcibloc; Calcigard; Calcilat; Camont; Cardifen; Cardilat; Cardionorm; Chronadalate; Citilat; Coracten; Coral; Cordafen; Cordaflex; Cordalat; Cordicant; Cordilan; Cordipin; Cordipine; Corinfar; Corotrend; Corynphar; Depin; Dignokonstant; Dilafed; Dipinkor; Duranifin; Ecodipi; Ecodipin; Emaberin; Fedcor; Fenamon; Fenigidin; Fenihidin; Fenihidine; Glopir; Hadipin; Hexadilat; Infedipin; Introcar; Kordafen; Korinfar; Macorel; Megalat; Myogard; Nedipin; Nicardia; Nifangin; Nifar; Nifdemin; Nifebene; Nifecard; Nifecor; Nifedepat; Nifediac; Nifedical; Nifedicor; Nifedin; Nifedine; Nifedipino; Nifedipinum; Nifedipres; Nifelan; Nifelat; Nifelate; Nificard; Nifidine; Nifipen; Niphedipine; Orix; Oxcord; Pidilat; Procardia; Sepamit; Tibricol; Vascard; Zenusin; AWD Pharma Brand of Nifedipine; Adalat CC; Adalat CR; Adalat Crono; Adalat FT; Adalat GITS; Adalat LA; Adalat LP; Adalat Oros; Adalat PA; Adalat Retard; Adalat XL; Adalate LP; Adcock Ingram Brand of Nifedipine; Adipine XL; Afeditab CR; Alonix S; Aprical long; Bayer Brand of Nifedipine; Chronadalate LP; Coracten XL; Ecodipin E; Fedcor Retard; Fenamon SR; Fortipine LA; KRKA Brand of Nifedipine; Nifedical XL; Nifedipine Bayer Brand; Nifedipine GTIS; Nifedipine KRKA Brand; Nifedipine Monohydrochloride; Nifedipine Orion Brand; Nifedipine Pfizer Brand; Nifedipine Retard; Nifedirex LP; Nifelat Q; Nifensar XL; Orion Brand of Nifedipine; Pfizer Brand of Nifedipine; Procardia XL; Slofedipine XL; Tensipine MR; Adalat 10; Adalat 20; Adalat 5; Adalat GITS 30; Bay1040; N 7634; N1fedilat; Adalat (TN); Afeditab CR (TN); Alpha-Nifedipine Retard;Apo-Nifed; Bay-1040; KB-1712P; Monohydrochloride, Nifedipine; Nifedical (TN); Nifedipine-GTIS; Nifedipino [INN-Spanish]; Nifedipinum [INN-Latin]; Procardia (TN); Bay-a-1040; Nifedipine (JP15/USP/INN); Nifedipine [USAN:BAN:INN:JAN]
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| Activity |
Ki = 244000 nM
|
[8] | |||
| Compound Name |
(4S)-1-Benzyl-4-[(4-methoxyphenyl)methyl]-4,5-dihydroimidazol-2-amine;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3741961; BDBM50499698
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| Activity |
Ki > 200000 nM
|
[10] | |||
| Compound Name |
(8As)-2-benzyl-1,5,6,7,8,8a-hexahydroimidazo[1,5-a]pyridin-3-imine;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3742187; BDBM50499697
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| Activity |
Ki > 200000 nM
|
[10] | |||
| Compound Name |
(10As)-2-(2-pyridin-2-ylethyl)-1,5,10,10a-tetrahydroimidazo[1,5-b]isoquinolin-3-imine;dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3741118; BDBM50499689
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||||
| Activity |
Ki > 200000 nM
|
[10] | |||
| Compound Name |
4-[[(4S)-2-Amino-1-benzyl-4,5-dihydroimidazol-4-yl]methyl]phenol;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3740152; BDBM50499690
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| Activity |
Ki > 200000 nM
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[10] | |||
| Compound Name |
(10As)-2-(2-morpholin-4-ylethyl)-1,5,10,10a-tetrahydroimidazo[1,5-b]isoquinolin-3-imine;dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3740794; BDBM50499699
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| Activity |
Ki > 200000 nM
|
[10] | |||
| Compound Name |
(4S)-1-Benzyl-4-methyl-4,5-dihydroimidazol-2-amine;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3740229; BDBM50499691
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| Activity |
Ki > 200000 nM
|
[10] | |||
| Compound Name |
(10As)-2-hexyl-1,5,10,10a-tetrahydroimidazo[1,5-b]isoquinolin-3-imine;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3739476; BDBM50499694
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| Activity |
Ki > 200000 nM
|
[10] | |||
| Compound Name |
(4S)-1,4-Dibenzyl-4,5-dihydroimidazol-2-amine;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3741891; BDBM50499693
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| Activity |
Ki > 200000 nM
|
[10] | |||
| Compound Name |
(4S)-1-Benzyl-4-[(4-fluorophenyl)methyl]-4,5-dihydroimidazol-2-amine;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3740044; BDBM50499700
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||||
| Activity |
Ki > 200000 nM
|
[10] | |||
| Compound Name |
1,4-Dibenzyl-3-methylimidazolidin-2-imine;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3740409; BDBM50499692
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||||
| Activity |
Ki > 200000 nM
|
[10] | |||
| Compound Name |
2-Cyclohexyl-4,6-dimethyl-2,4-dihydro-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100389; BDBM50040050; 2-Cyclohexyl-4,6-dimethyl-2H-1,2,3-triazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione
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| Activity |
Ki = 250000 nM
|
[7] | |||
| Compound Name |
1-Cyclopentyl-4,6-dimethyl-1,4-dihydro-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100909; BDBM50040047; 1,3-dimethyl-7-cyclopentyl-8-azaxanthine; 1-Cyclopentyl-4,6-dimethyl-1H-1,2,3-triazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione
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| Activity |
Ki = 292000 nM
|
[7] | |||
| Compound Name |
(2-Amino-4H-indeno[1,2-d][1,3]thiazol-5-yl) acetate;hydroiodide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL39388; BDBM50451380
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| Activity |
EC50 = 15848931.92 nM
|
[35] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists. J Med Chem. 2006 Jun 15;49(12):3682-92. | ||||
| REF 2 | Effects of alkyl substitutions of xanthine skeleton on bronchodilation. J Med Chem. 1992 Oct 30;35(22):4039-44. | ||||
| REF 3 | Structure-activity relationships of adenosines with heterocyclic N6-substituents. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6779-84. | ||||
| REF 4 | 5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 ... Bioorg Med Chem. 2008 Jan 1;16(1):336-53. | ||||
| REF 5 | Synthesis of eudistomin D analogues and its effects on adenosine receptors. Bioorg Med Chem. 2008 Apr 1;16(7):3825-30. | ||||
| REF 6 | Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5891-4. | ||||
| REF 7 | 8-Azaxanthine derivatives as antagonists of adenosine receptors. J Med Chem. 1994 Sep 2;37(18):2970-5. | ||||
| REF 8 | Mutagenesis reveals structure-activity parallels between human A2A adenosine receptors and biogenic amine G protein-coupled receptors. J Med Chem. 1997 Aug 1;40(16):2588-95. | ||||
| REF 9 | Novel adenosine A(2A) receptor ligands: a synthetic, functional and computational investigation of selected literature adenosine A(2A) receptor antagonists for extending into extracellular space. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3427-33. | ||||
| REF 10 | Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines. Eur J Med Chem. 2015 Dec 1;106:15-25. | ||||
| REF 11 | A facile and novel synthesis of N(2)-, C(6)-substituted pyrazolo[3,4-d]pyrimidine-4 carboxylate derivatives as adenosine receptor antagonists. Eur J Med Chem. 2015 Mar 6;92:784-98. | ||||
| REF 12 | Discovery of 7-(Prolinol-N-yl)-2-phenylamino-thiazolo[5,4-d]pyrimidines as Novel Non-Nucleoside Partial Agonists for the A2A Adenosine Receptor: Prediction from Molecular Modeling. J Med Chem. 2016 Jun 23;59(12):5922-8. | ||||
| REF 13 | Does the combination of optimal substitutions at the C2-, N5- and N8-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A1 adenosine receptors?. Bioorg Med Chem. 2011 Oct 15;19(20):6120-34. | ||||
| REF 14 | 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. | ||||
| REF 15 | Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. J Med Chem. 2010 Feb 25;53(4):1799-809. | ||||
| REF 16 | New insight into adenosine receptors selectivity derived from a novel series of [5-substituted-4-phenyl-1,3-thiazol-2-yl] benzamides and furamides. Eur J Med Chem. 2013 May;63:924-34. | ||||
| REF 17 | Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2935-9. | ||||
| REF 18 | Discovery of simplified N?substituted pyrazolo[3,4-d]pyrimidine derivatives as novel adenosine receptor antagonists: efficient synthetic approaches, biological evaluations and molecular docking studies. Bioorg Med Chem. 2014 Mar 1;22(5):1751-65. | ||||
| REF 19 | Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1931-4. | ||||
| REF 20 | US patent application no. 8501708B2, Adenosine compounds and their use thereof | ||||
| REF 21 | Scaffold decoration at positions 5 and 8 of 1,2,4-triazolo[1,5-c]pyrimidines to explore the antagonist profiling on adenosine receptors: a preliminary structure-activity relationship study. J Med Chem. 2014 Jul 24;57(14):6210-25. | ||||
| REF 22 | The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition. J Med Chem. 2010 Apr 22;53(8):3361-75. | ||||
| REF 23 | N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine recept... J Med Chem. 2009 Apr 23;52(8):2393-406. | ||||
| REF 24 | Novel thiazole-thiophene conjugates as adenosine receptor antagonists: synthesis, biological evaluation and docking studies. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1306-9. | ||||
| REF 25 | Discovery of 2-aminoimidazole and 2-amino imidazolyl-thiazoles as non-xanthine human adenosine A 3 receptor antagonists: SAR and molecular modeling studies. Medchemcomm. 2018 Mar 13;9(4):676-684. | ||||
| REF 26 | Synthesis of a series of 8-(substituted-phenyl)xanthines and a study on the effects of substitution pattern of phenyl substituents on affinity for adenosine A(1) and A(2A) receptors. Eur J Med Chem. 2009 May;44(5):2122-7. | ||||
| REF 27 | Medicinal chemistry of A1 adenosine receptor modulators: pharmacological activities and therapeutic implications. J Med Chem. 2012 Jun 28;55(12):5676-703. | ||||
| REF 28 | Progress in the development of small molecules as new human A3 adenosine receptor ligands based on the 3-thiophenylcoumarin core. Medchemcomm. 2016;7:845-52. | ||||
| REF 29 | Structure-Based Design, Synthesis, and In Vivo Antinociceptive Effects of Selective A 1 Adenosine Receptor Agonists. J Med Chem. 2018 Jan 11;61(1):305-318. | ||||
| REF 30 | [1,2,4]Triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: Modifications at the 8 position to reach selectivity towards A 3 adenosine receptor subtype. Eur J Med Chem. 2018 Sep 5;157:837-851. | ||||
| REF 31 | Potent, Selective Adenosine A1 Agonists as Potential Analgesics. Med Chem Res. 2004;13:88-98. | ||||
| REF 32 | New potent and selective A 1 adenosine receptor antagonists as potential tools for the treatment of gastrointestinal diseases. Eur J Med Chem. 2018 May 10;151:199-213. | ||||
| REF 33 | Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists. J Med Chem. 2000 Jun 1;43(11):2196-203. | ||||
| REF 34 | Synthesis and pharmacological evaluation of dual acting ligands targeting the adenosine A2A and dopamine D2 receptors for the potential treatment of Parkinson's disease. J Med Chem. 2015 Jan 22;58(2):718-38. | ||||
| REF 35 | 2-Aminothiazoles: a new class of agonist allosteric enhancers of A(1) adenosine receptors. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1563-6. | ||||
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