Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00OYQ
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| Former ID |
DIB012262
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| Drug Name |
Imisopasem manganese
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| Synonyms |
KM-4403; M-40403; Imisopasem manganese (dermatological, psoriasis/atopic dermatitis); Imisopasem manganese (dermatological,psoriasis/atopic dermatitis), ActivBiotics; Imisopasem manganese (dermatological, psoriasis/atopic dermatitis), Metaphore; M-40403 (dermatological, psoriasis/atopic dermatitis), Metaphore
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| Drug Type |
Small molecular drug
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| Indication | Pain [ICD-11: MG30-MG3Z] | Phase 2 | [1] | |
| Company |
MetaPhore Pharmaceuticals
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| Structure |
 |
Download2D MOL
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| Formula |
C21H35Cl2MnN5
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| Canonical SMILES |
C1CCC2C(C1)NCCNC3CCCCC3NCC4=CC=CC(=N4)CN2.Cl[Mn]Cl
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| InChI |
1S/C21H35N5.2ClH.Mn/c1-3-10-20-18(8-1)22-12-13-23-19-9-2-4-11-21(19)25-15-17-7-5-6-16(26-17)14-24-20;;;/h5-7,18-25H,1-4,8-15H2;2*1H;/q;;;+2/p-2/t18-,19-,20-,21-;;;/m1.../s1
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| InChIKey |
WXEMWBBXVXHEPU-XNPJUPKFSA-L
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Superoxide dismutase Mn (SOD Mn) | Target Info | Modulator | [2], [3] |
| BioCyc | Reactive oxygen species degradation | |||
| KEGG Pathway | FoxO signaling pathway | |||
| Peroxisome | ||||
| Huntington's disease | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| IL5 Signaling Pathway | ||||
| Pathway Interaction Database | FoxO family signaling | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00101621) Pilot Study to Evaluate the Safety and Analgesic Activity of M40403 Co-Administered With an Opioid Agent for Cancer Pain. U.S. National Institutes of Health. | |||
| REF 2 | The manganese superoxide dismutase mimetic, M40403, protects adult mice from lethal total body irradiation. Free Radic Res. 2010 May;44(5):529-40. | |||
| REF 3 | M-40403 Metaphore Pharmaceuticals. IDrugs. 2005 Jan;8(1):67-76. | |||
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