Drug Information
Drug General Information | Top | |||
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Drug ID |
D00WHO
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Former ID |
DNC014568
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Drug Name |
Ro-15-3505
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Synonyms |
Ethyl 8-chloro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate; Ethyl 8-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate; 78756-33-9; Ro 15-3505; CHEMBL415290; Ro-15-1310; QORLMYYHZLDYOR-UHFFFAOYSA-N; Ro-151310; AC1Q3QUM; AC1L3G5E; SCHEMBL5748925; CTK8D9399; DTXSID40229273; ZINC5114833; BDBM50034839; AKOS030600134; ethyl 8-chloro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate; ethyl 8-chloro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate; 4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid,; Sarmazenil
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C15H14ClN3O3
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Canonical SMILES |
CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC=C3Cl)C
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InChI |
1S/C15H14ClN3O3/c1-3-22-15(21)13-11-7-18(2)14(20)12-9(16)5-4-6-10(12)19(11)8-17-13/h4-6,8H,3,7H2,1-2H3
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InChIKey |
WSDBAFQWNWJTNG-UHFFFAOYSA-N
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CAS Number |
CAS 78771-13-8
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Inhibitor | [1] |
GABA(A) receptor alpha-2 (GABRA2) | Target Info | Inhibitor | [2] | |
GABA(A) receptor alpha-3 (GABRA3) | Target Info | Inhibitor | [2] | |
GABA(A) receptor alpha-5 (GABRA5) | Target Info | Inhibitor | [2] | |
GABA(A) receptor beta-2 (GABRB2) | Target Info | Inhibitor | [1] | |
GABA(A) receptor gamma-2 (GABRG2) | Target Info | Inhibitor | [1] | |
GABA(A) receptor gamma-3 (GABRG3) | Target Info | Modulator | [3] | |
Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [2] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Retrograde endocannabinoid signaling | ||||
GABAergic synapse | ||||
Morphine addiction | ||||
Nicotine addiction | ||||
Serotonergic synapse | ||||
Reactome | Ligand-gated ion channel transport | |||
GABA A receptor activation | ||||
WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||
Iron uptake and transport | ||||
SIDS Susceptibility Pathways |
References | Top | |||
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REF 1 | Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. | |||
REF 2 | The GABA(A) receptor as a target for photochromic molecules. Bioorg Med Chem. 2010 Nov 15;18(22):7731-8. | |||
REF 3 | Molecular structure and stereoelectronic properties of sarmazenil--a weak inverse agonist at the omega modulatory sites (benzodiazepine receptors):... Bioorg Med Chem. 1998 Oct;6(10):1745-57. |
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