Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D01BVI
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| Former ID |
DIB016550
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| Drug Name |
V-101
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| Synonyms |
TETRASUL; Tetradisul; Animert; 2227-13-6; Animert V-10; Animert V-10K; Animert V-101; Philips-duphar V-101; Caswell No. 213; Tetrasul [BSI:ISO]; UNII-BEO7JP5U0R; ENT 27,115; 2,4,4',5-Tetrachlorodiphenyl sulfide; 2,4,5,4'-Tetrachlorodiphenyl sulfide; 2,4,4',5-Tetrachlorodiphenyl sulphide; V-101; V 101; p-Chlorophenyl 2,4,5-trichlorophenyl sulfide; 4-Chlorophenyl 2,4,5-trichlorophenyl sulfide; Sulfide, p-chlorophenyl 2,4,5-trichlorophenyl; EINECS 218-761-4; BEO7JP5U0R; 3,4,6,4'-Tetrachlor-diphenylsulfid; EPA Pesticide Chemical Code
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| Drug Type |
Small molecular drug
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| Indication | Erythema [ICD-11: ME64.0; ICD-9: 695] | Phase 2 | [1] | |
| Company |
Vicept Therapeutics Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C12H6Cl4S
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| Canonical SMILES |
C1=CC(=CC=C1SC2=CC(=C(C=C2Cl)Cl)Cl)Cl
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| InChI |
1S/C12H6Cl4S/c13-7-1-3-8(4-2-7)17-12-6-10(15)9(14)5-11(12)16/h1-6H
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| InChIKey |
QUWSDLYBOVGOCW-UHFFFAOYSA-N
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| CAS Number |
CAS 2227-13-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
6117681, 8162500, 24862557, 29217921, 29284519, 48413449, 49857254, 57329472, 57649564, 75227897, 104340503, 124489704, 124893233, 126409829, 129078622, 134983333, 137012811, 144209590, 144213301, 162252226, 164817940, 165373836, 176263564, 184583685, 198976120, 223447082, 223518516, 226414346, 241238158, 242176395, 250101386, 252329535
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| ChEBI ID |
CHEBI:82162
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor alpha-2C (ADRA2C) | Target Info | Agonist | [2] |
| KEGG Pathway | cGMP-PKG signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Reactome | Adrenoceptors | |||
| Adrenaline signalling through Alpha-2 adrenergic receptor | ||||
| Adrenaline,noradrenaline inhibits insulin secretion | ||||
| G alpha (i) signalling events | ||||
| G alpha (z) signalling events | ||||
| Surfactant metabolism | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Platelet Aggregation (Plug Formation) | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01186068) Dose Response Study of Patients With Erythematous Rosacea. U.S. National Institutes of Health. | |||
| REF 2 | Rosacea: update on management and emerging therapies. Skin Therapy Lett. 2012 Dec;17(10):1-4. | |||
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